New Modes of GPCR Signalling
New Modes of GPCR Signalling
New Modes of GPCR Signalling
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Cordycepin Protects Against Brain ischemical Reperfusion Injury in<br />
Mice by Inhibition <strong>of</strong> Matrix Metalloproteinases-3 Expression.<br />
Zhenyong Cheng , Lianjun Guo*,Qing Lv, Xulin Xu<br />
Department <strong>of</strong> Pharmacology ,Tongji medical college,Huazhong University <strong>of</strong> Science<br />
and Technology, WuHan, China 430030<br />
Aim: the neuronal death following transient global ischemia - reperfusion in the mouse<br />
takes to occur, Since matrix metalloproteinase-3 (MMP-3) enhances inflammation and<br />
promotes apoptosis in ischemia – reperfusion. providing a potential neuroprotective<br />
effect <strong>of</strong> cordycepin. Methods: Kun ming male mice (18-25g) were randomly divided<br />
into five groups:control group, brain ischemic- reperfusion injury group, cordycepin<br />
10mg/kg, 20mg/kg and extract <strong>of</strong> cordyceps militaris(CME) treatmented groups. The<br />
bilateral common carotid artery was occlusion (2VO) for 15 min, and then subjected to<br />
a subsequent 4h period <strong>of</strong> ischemia reperfusion. The brain protein was extracted and<br />
the expression <strong>of</strong> matrix metalloproteinases-3(MMP-3) was measured by western blot<br />
analysis. Results: The expression <strong>of</strong> MMP-3 in the cordycepin- treated group(10mg/kg)<br />
and CME group were decreased by 45.8% and 41.6% contrast with model<br />
group(P
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