New Modes of GPCR Signalling

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Implication of the env Gene of the Human Endogenous Retrovirus W Family in the Expression of BDNF and DRD3 Shan Li, Honglian Yu, Lijuan Liu, Wang Zheng, Chunlan Liu, Jie Zeng, Yabing Wang, and Fan Zhu* School of Basic Medical Science, Wuhan University It has been reported that HERVs play functional roles in some diseases, such as tumor, some types of schizophrenia, bipolar disorder, and so on. However, how HERVs contribute to these diseases is far from clear. We found that HERV-W env could activate BDNF pathways that might result in the development of schizophrenian. In this study, U251 Cells were used to study whether HERV env protein could active the BDNF pathways on the molecular level.
Microvavle Immobilization of Intact C. Elegans for in vivo Calcium Imaging of Neuronal Activities in Response to External Stimuli Jingjing Wang, Xiaojun Feng, Wei Du, Bi-Feng Liu* Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People’s Republic of China. Aim To immobilize intact young adult C. elegans for imaging and explore neuronal activities in response to the changing environments. Methods We adopted a harmless and innocuous method to immobilize awake behaving C. elegans in a microfluidic device for imaging in vivo neuronal responses to controllable drug stimuli. A comb-shaped microfluidic valve was developed for the immobilization of living C. elegans with minimal influence on its activity for a long period of time. Results Our microfluidic device achieved the complete immobilization effect of living C. elegans, similar to the glue-based method. In coupling to a single-drug delivery system, we investigated the neuronal response and adaptation of the amphid polymodal ASH sensory neurons to repeated rapid, sharp stimuli such as high concentrations of glycerol. With a multi-drug delivery system, we sequentially stimulated the same animal with three different chemical reagents, resulting in successful differentiation between mutants and wild type. Conclusion The PDMS comb-shaped microvalve demonstrates the complete immobilization of awake behaving C. elegans. Microfluidic devices also provide micrometer-sized scales for rapid and sharp change in microenvironment to observe neuron responses to controllable drug stimuli. Thus, sensitive imaging of neuronal activities can be conducted in vivo. We expect that microfluidic chips can be used to study different aspects of nervous system in C. elegans. Key Words: C. elegans, microfluidic, comb-shaped valve, neuronal activities *Corresponding author Email: bfliu@mail.hust.edu.cn Tel: 86-27-87792203
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