New Modes of GPCR Signalling

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INVITED SPEAKER’S INFO Prof. John Wemmie MD, PhD, Assistant Professor University of Iowa, Roy J and Lucille A Carver College of Medicine, Department of Psychiatry 500 EMRB, Iowa City IA 52242 Tel: 319 335 6540 Fax: 319 335 7623 Email: john-wemmie@uiowa.edu Education 1989 BA, Central College, , Chemistry, Pella, IA 1988 Trinity College, Foreign Study Carmarthen, Wales, UK Program 1992 St. Petersburg State University, Intensive Russian, St. Petersburg, Russia, Language 1996 PhD, University of Iowa Department of Physiology and Biophysics, Iowa City, 1996 M.D, University of Iowa College of Medicine, Iowa City, 2000 Residency Psychiatry,University of Iowa Hospitals and Clinics Selected Publications 1. Wemmie J, Chen J, Askwith C, Hruska-Hageman A, Price M, Nolan B, Yoder P, Lamani E, Hoshi T, Freeman J, Welsh M: The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory. Neuron (34): 463-477, 2002. 2. Wemmie J, Askwith C, Lamani E, Cassell M, Freeman J, Welsh M: ASIC1 is Localized in Brain Regions with High Synaptic Density and Contributes to Fear Conditioning. J Neurosci 23:5496-5502, 2003. 3. Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ: cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci U S A. Feb 18;100 (4):2029-34, 2003. 4. Xiong Z, Zhu X, Chu X, Minami M, Hey J, Wemmie JA, Price MP, Welsh MJ, Simon RP, Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels, Cell 118(6):687-698, 2004. 5. Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ: Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci USA. 2004 Mar 9;101(10):3621-6. Epub 2004 Feb 26. 6. Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG: Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci 2004 Oct 6;24(40):8678-89.
7. Zha X-M, Wemmie JA, Welsh MJ (2006) ASIC1a is a postsynaptic proton receptor that influences the density of dendritic spines. Proc Natl Acad Sci USA 103:16556-16561. 8. Coryell M, Espie-Ziemann A, Westmoreland P, Haenfler J, Kurjakovic Z, Zha X, Price M, Schnizler M, Wemmie J. Targeting ASIC1a reduces innate fear and alters neural activity in the fear circuit. Biological Psychiatry. 2007 Jul 27; 9. Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, Fugger L. Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med. 2007 Dec;13(12):1483-9. Epub 2007 Nov 11. 10. Ziemann AE, Schnizler MK, Albert GW, Severson MA, Howard III MA, Welsh MJ, Wemmie JA. Seizure termination by acidosis depends on ASIC1a. Nat Neurosci. 2008 Jul;11(7):816-22. Epub 2008 Jun 8. 11. Coryell M, Wunsch A, Haenfler J, Allen J, McBride J, Davidson B, Wemmie J, Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knockout Mice Rescues Fear Memory but not Unconditioned Fear Responses. J Neurosci. 2008 Dec 17;28(51):13738-41. 12. Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. Zha XM, Wang R, Collier DM, Snyder PM, Wemmie JA, Welsh MJ. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3573-8. 13. Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. Coryell MW, Wunsch AM, Haenfler JM, Allen JE, Schnizler M, Ziemann AE, Cook MN, Dunning JP, Price MP, Rainier JD, Liu Z, Light AR, Langbehn DR, Wemmie JA. J Neurosci. 2009 Apr 29;29(17):5381-8 14. Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell MW, Wunsch AM, Lynch CM, Faraci FM, Howard III MA, Welsh MJ, Wemmie JA. The Amygdala Is a Chemosensor that Detects Hypercarbia and Acidosis to Elicit Fear Behavior. Cell, 2009 Volume 139, Issue 5, 1012-1021, 25 November 2009 15. Wemmie JA, Price MP, Welsh MJ (2006) Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci 29:578-586. 16. Kathleen A. Sluka, Olivia C. Winter, John A. Wemmie. Acid-Sensing Ion Channels: A New Target for Pain and CNS Diseases. Curr Opin Drug Discov Devel. 2009 Sep;12(5):693-704. 17. J. Render1, K. Howe, A. Wunsch, S. Guionaud, P. Cox, J. Wemmie Histologic Examination of the Eye of Acid-Sensing Ion Channel 1a Knockout Mice, Int J Physiol Pathophysiol Pharmacol 2010;2(1):69-72
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