New Modes of GPCR Signalling
New Modes of GPCR Signalling
New Modes of GPCR Signalling
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INVITED SPEAKER’S INFO<br />
Pr<strong>of</strong>. XianZhong Xu<br />
PhD, Assistant Pr<strong>of</strong>essor<br />
Dept <strong>of</strong> <strong>of</strong> Molecular & Integrative Physiology<br />
Life Sciences Institute, 6115A<br />
The University <strong>of</strong> Michigan<br />
Ann Arbor, MI 48109<br />
Tel: (734)615-9311<br />
Email: shawnxu@umich.edu<br />
Education<br />
1987-1991 B.S in Biochemistry , Wuhan University, Wuhan, China ,<br />
1991-1994 M.S in Biochemistry , Wuhan University, Wuhan, China,<br />
1995-2000 MD, Ph.D in Neuroscience& Biochem.<br />
Johns Hopkins University, Baltimore,<br />
2001-2005 Postdoc Neuroscience & Genetics<br />
California Institute <strong>of</strong> Technology, Pasadena, CA,<br />
Positions and Employment<br />
1991-1993 Guest researcher, National Laboratory <strong>of</strong> Biomacromolecules,<br />
Institute <strong>of</strong> Biophysics, Chinese Academy <strong>of</strong> Sciences, Beijing, China.<br />
2005- Assistant Pr<strong>of</strong>essor, Dept <strong>of</strong> Molecular & Integrative Physiology &<br />
Life Sciences Institute, The University <strong>of</strong> Michigan, Ann Arbor, MI.<br />
Selected Publications<br />
1. Xu, X.Z.S.*, Li, H. S.*, Guggino, W.B., and Montell, C. (1997). Coassembly <strong>of</strong><br />
TRP and TRPL produces a distinct store operated conductance. Cell 89, 1155<br />
1164.<br />
2. Xu, X.Z.S., Choudhury, A., Li, X., and Montell, C. (1998). Coordination <strong>of</strong> an<br />
array <strong>of</strong> signaling proteins through homo- and heteromeric interactions between<br />
PDZ domains and target proteins. Journal <strong>of</strong> Cell Biology 142, 545-555<br />
3. Xu, X.Z.S., Wes, P., Li, H. S., Yu, M., Morgan, S., Liu Y., and Montell, C. (1998)<br />
Retinal targets for calmodulin include proteins implicated in synaptic transmission.<br />
J. Biol.Chem 273, 31297-31307.<br />
4. Wes P. D*., Xu, X.Z.S.*, Li, H.-S., Chen, F., Doberstein, S. K., and Montell, C.<br />
(1999) Termination <strong>of</strong> phototransduction requires binding <strong>of</strong> the NINAC myosin<br />
III and the PDZ protein INAD. Nature Neuroscience 2, 447-453.<br />
5. Li, H.-S., Xu, X.Z.S., and Montell, C. (1999) Activation <strong>of</strong> a TRPC3-dependent<br />
cation current through the neurotrophin BDNF. Neuron 24, 261-273.<br />
6. Xu, X.Z.S., Chien, F., Butler, A., Salk<strong>of</strong>f, L., and Montell, C. (2000) TRP , a<br />
Drosophila TRP-related subunit, forms a regulated cation channel with TRPL.<br />
Neuron 26, 647-657.<br />
7. Xu, X.Z.S., Moebius, F., Gill, D.L., and Montell, C. (2001) Regulation <strong>of</strong>
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