New Modes of GPCR Signalling

More documents

Recommendations

Info

prephosphorylated by PKA in rat brain. J Biol Chem. 279(48):50078-88, 2004. 8. Wang JZ, Grundke-Iqbal I, Iqbal K. Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer disease. Nat Med. 2(8): 870-6, 1996
ABSTRACT The Synaptic Mechanisms of Glycogen Synathese Kinase-3 in Regulating Leaning and Memory Jian-Zhi Wang, Ling-Qiang Zhu, Dan Liu, Juan Hu, Qun Wang Pathophysiology Department, Key Laboratory of Education Committee on Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Previous studies have demonstrated that upregulation of glycogen synathese kinase-3 (GSK-3 ) impairs learning and memory in rats and transgenic mouse models, and ctivation of GSK-3 inhibits long term potentiation with mechanisms involving a decreased presynaptic glutamate release. To further verify the mechanisms underlying the impaired synaptic vesicle exocytosis, we have recently demonstrated that activation of GSK-3 could inhibit calcium influx through phosphorylating the intracellular loop connecting domains II and III (LII-III) of P/Q-type Ca 2+ channels, which leads to decrease of intracellular Ca 2+ influx through the P/Q-type voltage-dependent calcium channel (VDCC). GSK-3 interferes with the formation of SNARE complex through (i) weakening the association of synaptobrevin with SNAP25 and syntaxin; (ii) reducing the interaction between the phosphorylated LII-III and synaptotagmin, SNAP25 and syntaxin; and (iii) inhibiting dissociation of synaptobrevin from synaptophysin I, all of which are required for SNARE complex formation and thus for an efficient exocytosis. These results suggest that GSK-3 regulates synaptic vesicle cycle by affecting multiple steps in vesicular exocytosis.
Page 1 and 2: INVITED LIST OF INVITED SPEAKER’S
Page 3 and 4: LIST OF SOLICITED ABSTRACT Chemosen
Page 5 and 6: ................................105
Page 7 and 8: INVITED SPEAKER’S INFO Prof. Joë
Page 9 and 10: ABSTRACT New Modes of GPCR Signalli
Page 11 and 12: carcinogenesis in mice. Nature Gene
Page 13 and 14: INVITED SPEAKER’S INFO Prof. Jean
Page 15 and 16: ABSTRACT Sensing mGlu Receptor Acti
Page 17 and 18: metabotropic glutamate-like recepto
Page 19 and 20: INVITED SPEAKER’S INFO Prof. Deni
Page 21 and 22: ABSTRACT Manipulation of Rac Activi
Page 23 and 24: Activity-based Probe for Specific P
Page 25 and 26: INVITED SPEAKER’S INFO Prof. Yong
Page 27 and 28: ABSTRACT From Bench to Bedside: BAC
Page 29 and 30: photoreceptor cell specific protein
Page 31 and 32: INVITED SPEAKER’S INFO Prof. Huax
Page 33 and 34: ABSTRACT Novel Genes and Pathways t
Page 35 and 36: and Jiuping Ding. A residue at the
Page 37: INVITED SPEAKER’S INFO Prof. Jian
Page 41 and 42: melastatin, a TRP-related protein,t
Page 43 and 44: INVITED SPEAKER’S INFO Prof. Jean
Page 45 and 46: ABSTRACT Spatial Control of Synapti
Page 47 and 48: ROS/RNS generation. Free Radical Bi
Page 49 and 50: INVITED SPEAKER’S INFO Prof. Xi H
Page 51 and 52: ABSTRACT Mechanisms of Wnt Signalin
Page 53 and 54: 7. Zha X-M, Wemmie JA, Welsh MJ (20
Page 55 and 56: INVITED SPEAKER’S INFO Prof. Tao
Page 57 and 58: ABSTRACT Sequential Activation of O
Page 59 and 60: Chemosensory and Behavior of C.eleg
Page 61 and 62: Microvavle Immobilization of Intact
Page 63 and 64: Isoform-Specific Prolongation of KC
Page 65 and 66: UNC-31/CAPS Docks and Primes Dense
Page 67 and 68: Calcium Signaling in Astrocytes Ind
Page 69 and 70: Isolation, Characterization and Ant
Page 71 and 72: Role of Heat on the Expression and
Page 73 and 74: The Kv1.3 Channel Blocker Scorpion
Page 75 and 76: IGF-1 Promote BPH-1 Cell Proliferat
Page 77 and 78: Therapeutic Effect of Flupirtine on
Page 79 and 80: Therapeutic Effect of Flupirtine on
Page 81 and 82: Does the Metabotropic Glutamate Rec
Page 83 and 84: Imaging Neuronal Population in Vitr
Page 85 and 86: Phone: 86-27-85351625 A Novel Mutat
Page 87 and 88: MAPK Scaffolding by BIT1 in the Gol
Page 89 and 90:
Phosphoinositide-3-Kinase Pathway A
Page 91 and 92:
Akt Overexpression Opposes the Beta
Page 93 and 94:
Effects of ZD7288 on Long-Term Pote
Page 95 and 96:
Embryonic Heart Growth is Regulated
Page 97 and 98:
Quantitative Phosphoproteomics Anal
Page 99 and 100:
Morphine Regulated Thioredoxin-1 Ex
Page 101 and 102:
Investigate the Role of Rab27 in th
Page 103:
Effects of Cyclic Nucleotide Gated
show all

New Modes of GPCR Signalling

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?