New Modes of GPCR Signalling

β-Secretase (BACE1). Biological Medicinal Chemistry Letters, 19(1): 264-74.
9. Ewers, M., Zhong, Z., Teipel, S., Büger, K., Wallin, A., Blennow, K., and Shen, Y*.
and Hampel, H*.(2008). Increased CSF-BACE1 activity is associated with
ApoE-ε4 genotype in subjects with mild cognitive impairment and Alzheimer’s
disease, Brain, 131:1252-8.
10. Zhong, Z., Ewers, M., Teipel, S., Büger, K., Wallin, A., Blennow, K., Hampel, H.,
and Shen, Y. (2007). High Levels of Beta-Secretase (BACE1) in Cerebrospinal
Fluid as a Predictor of Risk in Mild Cognitive Impairment, the early stage of
Alzheimer ’s disease, Archive of General Psychiatry, 64(6):718-26.
11. He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, Staufenbiel M, Li R
and ShenY. (2007). Deletion of TNF death receptor inhibits amyloid beta
generation and prevents learning and memory deficits in Alzheimer’s mice.
Journal of Cell Biology, 178(5): 829-841. Highlighted as “Death receptor takes
central stage” by Nature Neuroscience,October, 2007; Hot story by Science, 2007.
12. Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M,
Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. (2007). Depletion of GGA3
stabilizes BACE and enhances beta-secretase activity. Neuron.54(5):721-37.
13. Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell
WH, He P, Lee VM, Woolf CJ, Kovacs DM. (2007). BACE1 regulates
voltage-gated sodium channels and neuronal activity. Nature Cell Biol.
9(7):755-64.
14. Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, Harada N, Zhong Z,
Shen Y, Li R. (2005). Brain estrogen deficiency accelerates Abeta plaque formation
in an Alzheimer's disease animal model. Proc Natl Acad Sci U S A.
102(52):19198-203.
15. Li R., Yang LB, Lindholm K, Yan R, Citron M, Beach T, Sue L, Subbagh M., Cai
H., Wong P, Price D, Shen Y.(2004). Aβ load is correlated with elevated BACE
activity in sporadic Alzheimer patients. Proc Natl Acad Sci U S A.),101(10),
3632-3637.
16. Li R., Lindholm K, Yang LB, Konishi Y, Hampel H, Zhang, D. Shen Y. (2004).
TNF death receptor signaling cascade is required for amyloid-β-protein induced
neuron death. J.Neurosci, 28(7), 1760-1771.
17. Yang LB, Lindholm K, Yan R, Citron M, Xia W, Beach T, Sue L, Wong P, Price D,
Li R, Shen Y. (2003). Elevated beta-secretase expression and enzymatic activity
detected in sporadic Alzheimer disease. Nature.Med, 9(1): 3-4
18. Yang, L-B., Lindholm, K., Konishi, Y., Li, R. and Shen, Y. (2002) Targeting
deletion of TNF receptor subtypes reveals hippocampal neuron survival and death
through distinct signal transduction pathways. J.Neurosci, 22(8), 3025-3032.
19. Yang, L-B., Li, R., Meri, S., Rogers, J. and Shen, Y. (2000) Deficiency of
complement protective protein, CD59 in Alzheimer’s brains may contribute to
neurodegeneration. J.Neurosci, 20(20), 7505-7509.