New Modes of GPCR Signalling

INVITED SPEAKER’S INFO
Prof. Yong Shen
PhD, Senior scientist/Professor
Haldeman Laboratory of Molecular and Cellular
Neurobiology
Sun Health Research Institute
10515 West Santa Fe Drive, Sun City, AZ, 85351, U.S.A.
Phone: (623)876-5456
Fax: (623)876-6688
Email: Yong.Shen@bannerhealth.com
Education
1983 Nanjing University, China BSc. Physiology
1986 Shanghai Inst. of Physiology, Academy of Sciences MSc. Neurophysiology
1989 State University of New York (SUNY) Ph.D. Neuroscience
Selected Publications
1. Ewers M, Cheng X, Nural HF, Walsh C, Meindl T, Teipel SJ, Buerger K, Shen Y,
Hampel H. (2010). CSF- BACE1 activity predicts hippocampus atrophy in
Alzheimer’s disease. J Alzheimers Dis, Apr 26.
2. Cheng X., Yang L., He P, Li R., Shen Y. (2010). Differential activation of TNF
receptors distinguishes Alzheimer from normal brains. J Alzheimers Dis,
19(2):621-30.
3. Ghosal P., Vogt D, Man L, Shen Y., Lamb B., Pimplikar, SW (2009). Alzheimer's
disease-like pathological features in transgenic mice expressing the APP
intracellular domain. Proc Natl Acad Sci U S A. 106(43): 18367-18377.
4. He, P., Staufenbiel M and Shen, Y. (2008). Interruption of β-catenin signaling
reduces neurogenesis in Alzheimer’s disease’s brains. Nature Proceedings,
September, and J.Neurosci. (2009), 29(20):6545-57.
5. The paper is selected as World Faculty 1000 and Feature Article Xia W., Yang T.,
Imelda M. Smith I. M., Shen Y., Walsh D. M. and Dennis J. Selkoe, D. J. (2009). A
specific ELISA for measuring amyloid β-protein oligomers in human plasma and
the brains of Alzheimer patients. Archives of Neurology, 66(2):190-9.
6. Nural F., He P, Beach T, Sue L, Xia W, and ShenY. (2009). Disassembled DJ-1
high molecular weight complex in cortex in cortex mitochondria from Parkinson’s
disease Patients. Molecular Neurodegeneration.
7. Kozikowski, A. P., Chen, Y., Subahasish, T., Zhong, Z., Melissa A. D’Annibale,
M.A., Shen, Y. and Langley, B.C. (2010). PKC activation and HDAC inhibition -A
dual drug approach to Alzheimer’s disease that reduces Aβ production while
blocking oxidative stress. Proc Natl Acad Sci U S A.. Submitted.
8. Chirapu, S. R, Pachaiyappan, B, Zhong, Z., Abdul-Hay, S. O., Yuan, H., Thatcher,
G., Shen, Y., Kozikowski, A. P, Petukhov, P. A. (2008). Molecular modeling,
Synthesis and Activity Studies of Inhibitors Targeting Alzheimer’s disease