New Modes of GPCR Signalling

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INVITED SPEAKER’S INFO Prof. Jianfeng Liu PhD, Professor, Vice director, Key laboratory of molecular biophysics of ministry of education Huazhong University of Science and Technology (HUST) 1037, Luoyu Road, Hubei, Wuhan, 430074, P.R.China Tel : 0086-27-87792031 Fax : 0086-27-87792024 Email : jfliu@mail.hust.edu.cn Education 1994 -1999 Ph.D. Molecular and Cell Biology, University of Paris XII, Paris, France. 1993 -1994 M.S. Biochemistry and Biotechnology, University of Paris XIII, Paris, France. 1989 -1993 B.S. Biochemistry, Department of Biochemistry, Wuhan University, Wuhan, China Research Experience 2002- Professor, College of Life Science and Technology, HuaZhong University of Science and technology, Wuhan, China. 2001-2002 Staff Scientist in Aventis Pharma, Bridgewater, New Jersey, USA. 1999-2001 Post-doc Fellow Institut Cochin Génétique Moléculaire (ICGM), Paris, France. 1994-1999 Research Assistant in the Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaire, University of Paris XII, Creteil, France. 1993-1994 Research assistant, Institut d’oncologie Cellulaire et Moléculaire Humaine,University of Paris XIII, Bobigny, France. Selected Publications 1. Tu HJ, Xu CJ, Zhang WH, Liu QY, Rondard P, Pin JP, Liu JF. (2010) GABAB receptor activation protects neurons from apoptosis via IGF-I receptor transactivation. J. Neurosci., 30(2): 749-759. 2. Cao JH, Huang SL, Qian J, Huang JL, Jin L, Su ZX, Yang J, Liu JF. (2009) Evolution of the class C GPCR Venus flytrap modules involved positive selected functional divergence. BMC Evol Biol., 9:67 . 3. Rondard P, Huang SL, Monnier C, Tu HJ, Blanchard B, Oueslati N, Malhaire F, Maurel D, Trinquet E, Li Y, Labesse G, Pin JP, Liu JF (2008). Functioning of the dimeric GABAB receptor extracellular domain revealed by glycan wedge scanning. EMBO J, 27(9):1321-32 4. Li X, Cao JH, Li Y, Rondard P, Zhang Y, Yi P, Liu JF, Nan FJ. (2008)
Activity-based Probe for Specific Photo-affinity Labelling of GABAB Receptors in Living Cells: Design, Synthesis and Biological Evaluation. J. Med. Chem 12;51(11):3057-60. 5. Huang S., Liu JF., Labesse G., Pin J.-P. & Rondard P. Rearrangement of the cystein-rich domains during metabotropic glutamate receptors activation. Manuscrit in preparation 6. Tu HJ, Rondard P, Xu CJ, Bertaso F, Cao FN, Zhang XY, Pin JP, Liu JF. (2007) GABAB2 subunit and Gßγ are necessary for GABAB receptor mediated-ERK1/2 phosphorylation in cerebellar granule neurons. Cell. Signal., 19(9):1996-2002. 7. Zhang YL, Zhang HQ, Hua SN, Ma LH, Chen C, Liu XY, Jiang LQ, Yang HM, Zhang PC, Yu DQ, Guo YL, Tan XH, Liu JF. (2007) Identify two herbal compounds with potential cholesterol-lowing activity. Biochem. Pharmaco., 74(6):940-7. 8. Rondard P, Liu JF, Huang SL, Malhaire F, Vol C, Pinault A, Pin JP. (2006) Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors. J. Biol. Chem., 281(34):24653-61. (co-first and corresponding author) 9. Pin JP, Kniazeff J, Liu JF, Binet V, Goudet C, Rondard P, Prézeau L. (2005) Allosteric functioning of dimeric class C G-protein-coupled receptors. FEBS Journal., 272(12): 2947-2955. 10. Liu JF, Maurel D, Etzol S, Brabet I, Pin JP, Rondard P.(2004) Molecular determinants involved in the allosteric control of agonist affinity in GABAB receptor by the GABAB2 subunit. J. Biol. Chem. , 279(16):15824-30. 11. Goudet C, Gaven F, Kniazeff J, Vol C, Liu JF, Cohen-Gonsaud M, Acher F, Prezeau L, Pin JP. (2004) Heptahelical domain of metabotropic glutamate receptor 5 functions like rhodopsin-like receptors. Proc. Natl. Acad. Sci., 101(1): 378-383. 12. Liu JF, Crepin M, Liu JM, Barritault D, Ledoux D. (2002) FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. Biochem. Biophys. Res. Com., 293: 1174-1182. 13. Liu JF, Chevet E, Lemaitre G, Barritault D, Larose L, Crepin M. (1999) Functional Rac-1 and Nck signaling networks are required for FGF-2-induced DNA synthesis in MCF-7 cells. Oncogene., 18: 6425-6433. 14. Liu JF, Issad T, Chevet E, Ledoux D, Courty J, Caruelle JP, Barritault D; Crepin M, Bertin B. (1998) Fibroblast growth factor-2 has opposite effects on human breast cancer MCF-7 cell growth depending on the activation level of the mitogen-activated protein kinase pathway. Eur. J. Biochem., 258: 271-276. 15. Liu JF, Bagheri-Yarmand R, Xia YL, Crepin M. (1997) Modulations of breast fibroblast and carcinoma cell interactions by a dextran derivative (CMDB7). Anticancer Res., 17: 253-258.
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