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New Modes of GPCR Signalling

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specificity <strong>of</strong> G protein activation in phospholipase C coupled metabotropic<br />

glutamate receptor. EMBO J 13: 342-348.<br />

8. Ango F, Prézeau L, Muller T, Worley PF, Pin J-P, Bockaert J and Fagni L (2001)<br />

Agonist-independent activation <strong>of</strong> mGluRs by the intracellular interacting protein,<br />

Homer. Nature 411: 962-965.<br />

9. Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prézeau L and Pin<br />

J-P (2001) Allosteric interactions between GB1 and GB2 subunits are required for<br />

optimal GABAB receptor function. EMBO J 20: 2152-2159.<br />

10. Bessis A-S, Rondard P, Gaven F, Brabet I, Triballeau N, Prézeau L, Acher F and<br />

Pin J-P (2002) Closure <strong>of</strong> the Venus Flytrap module <strong>of</strong> family 3 <strong>GPCR</strong>s is required<br />

for their activation: insights from mutations converting antagonists into agonists.<br />

Proc. Natl. Acad. Sci (USA), 99:11097-11102.<br />

11. Kniazeff J, Bessis A.-S, Maurel D, Ansanay H, Prezeau L and Pin J-P (2004)<br />

Closed state <strong>of</strong> both binding domains <strong>of</strong> homodimeric mGlu receptors is required<br />

for full activity. Nat. Str. Mol. Biol., 11: 706-713.<br />

12. Goudet C, Gaven F, Kniazeff J, Vol C, Liu J, Cohen-Gonsaud M, Acher F, Prézeau<br />

L and Pin J-P (2004) Heptahelical domain <strong>of</strong> metabotropic glutamate receptor 5<br />

behaves like rhodopsin-like receptors. Proc. Natl. Acad. Sci (USA), 101, 378-383.<br />

13. Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J,<br />

Prézeau L, Pin J-P, Blahos J (2005) Evidence for a single heptahelical domain<br />

being turned on upon activation <strong>of</strong> a dimeric <strong>GPCR</strong>. EMBO J. 24:499-509.<br />

14. Damian M, Martin A, Mesnier D, Pin JP, Banères JL (2006) Asymmetric<br />

conformational changes in a <strong>GPCR</strong> dimer controlled by G-proteins. EMBO J.<br />

25:5693-5702.<br />

15. Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y,<br />

Maurel D, Trinquet E, Labesse G, Pin* J-P, Liu J (2008) Functioning <strong>of</strong> the dimeric<br />

GABAB receptor extracellular domain revealed by glycan wedge scanning. EMBO<br />

J 27:1321-1332.<br />

16. Maurel D, Comps-Agrar L, Brock C, Rives M-L, Bourrier E, Ayoub MA, Bazin H,<br />

Tinel N, Durroux T, Prézeau L, Trinquet E, Pin J-P (2008) Cell surface<br />

protein-protein interaction analysis with combined time-resolved FRET and<br />

snap-tag technologies: application to <strong>GPCR</strong> oligomerization. Nat Meth 5:561-567.<br />

17. Rives ML, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub MA, Shigemoto R, Pin<br />

JP, Prezeau L (2009) Crosstalk between GABA(B) and mGlu1a receptors reveals<br />

new insight into <strong>GPCR</strong> signal integration. EMBO J. 28:2195-2208.<br />

18. Bartfai T, Benovic J, Bockaert J, Bond R, Bouvier M, Christopoulos A, Civelli O,<br />

Devi L, George S, Inui A, Kobilka B, Leurs R, Neubig R, Pin J-P, Quirion R,<br />

Roques B, Sakmar T, Seifert R, Stenkamp R, Strange P (2004) Twenty Questions<br />

on <strong>GPCR</strong>s. Nat Rev Drug Discovery. 3:577-626.

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