New Modes of GPCR Signalling

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INVITED SPEAKER’S INFO Prof. Kun-Liang Guan PhD, Professor UCSD Moores Cancer Center, RM5344, 3855 Health Sciences Dr., La Jolla, CA 92093-0815. Tel: 858-822-7945, E-mail: kuguan@ucsd.edu Education 1978-1982 Undergraduate student in the Department of Biology. Hangzhou University, China, B.S. 1982-1983 CUSBEA student, Graduate student in Shanghai Institute of Plant Physiology, Shanghai, China 1983-1989 Graduate student in the Department of Biochemistry, Purdue University, West Lafayette, Indiana, Ph.D. (Dec.17, 89) 1989-1991 Post doctoral fellow in the Department of Biochemistry, Purdue University (Mentor, Jack Dixon) Academic Appointments 1992-1996 Assistant Professor, Department of Biological Chemistry, University of Michigan 1996-2000 Associate professor, Department of Biological Chemistry, University of Michigan 2000-2007 Professor, Department of Biological Chemistry, University of Michigan 2002- Visiting professor, Department of Chemistry and Biochemistry, University of Colorado at Boulder 2003-2007 Research professor, Life Sciences Institute, University of Michigan 2003-2007 Halvor N. Christensen Collegiate Professor in Life Sciences, University of Michigan 2005- Adjunct professor, Fudan University, China 2007- Visiting Research professor, Life Sciences Institute, University of Michigan 2007- Professor, Department of Pharmacology, Member, Moores Cancer Center, University of California, San Diego Selected Publications over 180 1. Guan, K-L., Broyles, S.S., and Dixon, J.E. (1991) Vaccinia virus encodes a Tyr/Ser protein phosphatase. Nature. 350, 359-362. 2. Zhang, Z., Wang, Y., Vikis, H. G., Anderson, M.W., Sills, R.C., Holliday, W., Devereux, T.R., Guan, K-L., and You, M. (2001) Wild type ras can inhibit lung
carcinogenesis in mice. Nature Genetics. 29, 25-33. 3. Inoki, K., Li, Y., Zhu, T., Wu, J. and Guan, K-L. (2002) TSC2 is phosphorylated and inhibited by AKT and suppresses mTOR signaling. Nature Cell Biol. 4, 648-657. (Selected by Nature Cell Biol as one of the landmark papers). 4. Li, W., Lee, J., Vikis, H., et al, and Guan, K-L. (2004) Activation of FAK and Src are receptor proximal events required for netrin signaling. Nature. Neuroscience. 7, 1213-1221. 5. Kim, E., Goraksha, P., Li, L., Neufeld, T.P., and Guan, K-L. (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nature Cell Biol. 10, 935-945. 6. Chang, J., Wang, Z., Tang, E., Fan. Z., McCauley, L., Franceschi, R., Guan, K-L., Kresbach, PH., and Wang, C-Y. (2009) Inhibition of Osteoblast functions by IKK/NFkB in osteoporosis. Nature.Med. 15, 682-9. 7. Inoki, K., Corradetti, and Guan, K-L. (2005) Disease associated with TOR Dysregulation. Nature Genetics. 37, 19-24. 8. Guan, K-L. and Dixon, J.E. (1990) Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science. 249, 553-556. 9. Simon, A. R., Vikis, H.G., Fanburg, B.L., Stewart, S., Cochran, B.H., and Guan, K.-L. (2000) Regulation of STAT3 by direct binding to the small G protein Rac1. Science. 290, 144-147. 10. Zhao, S., Lin, Y., Xu., W., Jiang, W., Zha, Z., Wang, P., Yu, W., Li, Z., Gong, L., Peng, Y., Ding, J., Lei, Q., Guan, K-L., Xiong, Y. (2009) Glioma-derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1. Science. 324, 261-5. 11. Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zeng, Y., Li, H., Li, Y., Shi., J., An, W., Hancock, S.M., He., F., Qin, L., Chin, J., Yang, P., Chen, X., Lei, Q., Xiong, Y., Guan, K-L., (2010) Regulation of cellular metabolism by protein lysine acetylation. Science. 327, 1000-1004. 12. Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., Ning, Z-B., Zeng, R., Xiong, Y., Guan, K-L., Zhao, S., Zhao, G-P., (2010) Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science. 327, 1004-1007. 13. Inoki, K., Zhu, T., and Guan, K-L. (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell. 115, 577-590. 14. Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., Wang, C., He, H., MacDougald, O., You, M., Williams, B., and Guan, K-L. (2006) TSC2 integrates Wnt and cellular energy signals through a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 126, 955-68. 15. Mori, H., Inoki, K., Münzberg, H., Opland, D., Faouzi, M., Villanueva, E.C., Ikenoue, T., Kwiatkowski, D., MacDougald, O.A., Myers, M.G. Jr., and Guan, K-L. (2009) Critical role for hypothalamic mTOR activity in energy balance. Cell Metabolism. 9, 362-74. 16. Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Lin, JD., Wang, C- Y., Chinnaiyan, AM., Lai, Z-C., and Guan. K-L. (2008) TEAD mediates YAP dependent gene induction and growth control. Genes & Development. 22, 1962-71.
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Microvavle Immobilization of Intact
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Isoform-Specific Prolongation of KC
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UNC-31/CAPS Docks and Primes Dense
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Calcium Signaling in Astrocytes Ind
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Isolation, Characterization and Ant
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IGF-1 Promote BPH-1 Cell Proliferat
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Does the Metabotropic Glutamate Rec
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Phone: 86-27-85351625 A Novel Mutat
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