Immunotherapy for Infectious Diseases

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Preface ................................................................................................................... v List of Contributors............................................................................................ix I BASIC PRINCIPLES OF IMMUNITY 1 Humoral Immunity Peter L. Nara ........................................................................................................ 3 2 Some Basic Cellular Immunology Principles Applied to the Pathogenesis of Infectious Diseases R. Pat Bucy and Paul Goepfert ...................................................................... 23 3 Immune Defense at Mucosal Surfaces Prosper N. Boyaka and Jerry R. McGhee ..................................................... 39 II MOLECULAR BASIS FOR IMMUNOTHERAPY 4 Production of Immunoglobulins and Monoclonal Antibodies Targeting Infectious Diseases Renate Kunert and Hermann Katinger.......................................................... 63 5 Dendritic Cells: Their Role in the Immune Response to Infectious Organisms and Their Potential Use in Therapeutic Vaccination Smriti K. Kundu-Raychaudhuri and Edgar G. Engleman ......................... 99 6 Cytokines, Cytokine Antagonists, and Growth Factors for Treating Infections Barbara G. Matthews..................................................................................... 117 7 Principles of Vaccine Development Constantin A. Bona ....................................................................................... 129 III IMMUNOTHERAPY FOR HIV INFECTION 8 Immunopathogenesis of HIV Infection Lawrence M. Fox ............................................................................................. 151 9 Immune Reconstitution with Antiretroviral Chemotherapy Elizabeth Connick ........................................................................................... 163 10 Active Immunization as Therapy for HIV Infection Spyros A. Kalams ............................................................................................ 181 vii Contents
viii Contents 11 Passive Immunotherapy for HIV Infection Jeffrey M. Jacobson ......................................................................................... 199 12 Host Cell-Directed Approaches for Treating HIV and Restoring Immune Function J. Michael Kilby and R. Pat Bucy ................................................................ 221 13 Gene Therapy for HIV-1 Infection Ralph Dornburg and Roger J. Pomerantz.................................................. 237 IV IMMUNOTHERAPY FOR INFECTIOUS DISEASES OTHER THAN HIV 14 Immunotherapy for Viral Infections Other than HIV Michelle Onorato and Richard B. Pollard ................................................. 251 15 Immunotherapy for Virus-Associated Malignancies Uluhan Sili, Helen Heslop, and Cliona M. Rooney ................................. 259 16 Immunotherapy of Bacterial Infections and Sepsis Sam T. Donta ................................................................................................... 275 17 Immunotherapy for Tuberculosis and Other Mycobacterial Infections Robert S. Wallis and John L. Johnson......................................................... 283 18 Immunotherapy for Fungal Infections Arturo Casadevall........................................................................................... 303 Index .................................................................................................................. 323
Page 1 and 2: Immunotherapy for Infectious Diseas
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Page 5 and 6: © 2002 Humana Press Inc. 999 River
Page 7: vi Preface I am grateful to all of
Page 11 and 12: x Contributors BARBARA G. MATTHEWS,
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Page 16 and 17: Humoral Immunity 5 Fig. 1. Humoral
Page 18 and 19: Humoral Immunity 7 Table 1 Properti
Page 20 and 21: Humoral Immunity 9 minal complement
Page 22 and 23: Humoral Immunity 11 ficity. In ligh
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Page 28 and 29: Humoral Immunity 17 In contrast to
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Page 32 and 33: Humoral Immunity 21 32. Allman DM,
Page 34 and 35: Some Basic Cellular Immunology Prin
Page 36 and 37: Cellular Immunology Principles 25 i
Page 38 and 39: Cellular Immunology Principles 27 s
Page 40 and 41: Cellular Immunology Principles 29 d
Page 42 and 43: Cellular Immunology Principles 31 f
Page 44 and 45: Cellular Immunology Principles 33 F
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Page 50 and 51: INTRODUCTION Immune Defense at Muco
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Immune Defense at Mucosal Surfaces
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II Molecular Basis for Immunotherap
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64 Kunert and Katinger IMMUNOGLOBUL
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66 Fig. 2. Monomeric, dimeric, and
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68 Kunert and Katinger Fig. 4. Humo
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70 Kunert and Katinger remove prote
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72 Kunert and Katinger Fig. 6. Diff
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74 Kunert and Katinger persons of a
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76 Kunert and Katinger that so-call
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78 Kunert and Katinger whereas sele
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80 Kunert and Katinger Different pr
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82 Kunert and Katinger HUMAN/MOUSE
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84 Kunert and Katinger are expresse
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86 Kunert and Katinger missing meta
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88 Kunert and Katinger Fig. 8. Sche
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90 Kunert and Katinger include a se
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92 Kunert and Katinger 32. Lee S, e
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94 Kunert and Katinger 72. Abbs IC,
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96 Kunert and Katinger 117. Wright
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From: Immunotherapy for Infectious
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Dendritic Cells 101 several organis
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Dendritic Cells 103 tion that infec
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Dendritic Cells 105 chaperones such
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Dendritic Cells 107 CD8� CTLs, th
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Dendritic Cells 109 complete tumor
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Dendritic Cells 111 19. Holland SM,
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Dendritic Cells 113 mouse pneumonit
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Dendritic Cells 115 dendritic cells
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INTRODUCTION Cytokines, Cytokine An
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Cytokines, Cytokine Antagonists, an
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Principles of Vaccine Development F
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Principles of Vaccine Development 1
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INTRODUCTION Immunopathogenesis of
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Immunopathogenesis of HIV Disease 1
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164 Connick counts ranged from 73 t
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166 Connick retinitis in an individ
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168 Connick A novel method of ident
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170 Connick occurs quite early in i
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172 Connick 2. Delta Coordinating C
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174 Connick 39. Hurni MA, Bohlen L,
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176 Connick 76. Dolan M.J., Clerici
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178 Connick 114. Komanduri KV, Visw
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Active Immunization for HIV Infecti
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200 Jacobson changes of gp120 alter
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202 Jacobson is reduced (54,55). A
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204 Jacobson Table 2 Potential Prot
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206 Jacobson from the SIV/17E-Cl-in
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208 Jacobson Several groups have de
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210 Jacobson HUMAN STUDIES Polyclon
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212 Jacobson clinical isolates, whi
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214 Jacobson 22. Beasley RP, Hwang
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216 Jacobson 59. Yoshiyama H, Mo H,
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218 Jacobson 95. Prince AM, Reesink
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220 Jacobson 133. Stiehm ER, Lamber
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222 Kilby and Bucy Although clinica
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224 Kilby and Bucy can infect human
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226 Kilby and Bucy the proinflammat
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228 Kilby and Bucy CD3/CD28, and th
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230 Kilby and Bucy of viral replica
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232 Kilby and Bucy 21. Cao Y, Qin L
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234 Kilby and Bucy 64. Pantaleo G,
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236 Kilby and Bucy 101. Clements-Ma
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238 Dornburg and Pomerantz cells (5
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240 Dornburg and Pomerantz Fig. 2.
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242 Dornburg and Pomerantz domains
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244 Dornburg and Pomerantz GENETIC
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246 Dornburg and Pomerantz Fig. 5.
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248 Dornburg and Pomerantz 6. Balti
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Viral Infections Other than HIV 253
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Virus-Associated Malignancies 261 c
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Virus-Associated Malignancies 263 o
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Virus-Associated Malignancies 265 I
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Virus-Associated Malignancies 267 R
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Virus-Associated Malignancies 269 T
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Virus-Associated Malignancies 271 1
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Virus-Associated Malignancies 273 5
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Bacterial Infections and Sepsis 277
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284 Wallis and Johnson replication
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286 Wallis and Johnson Several stud
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288 Wallis and Johnson monocytes, a
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290 Wallis and Johnson peripheral b
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292 Wallis and Johnson (A. Hise and
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294 Wallis and Johnson infections,
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296 Wallis and Johnson 37. Boom WH.
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298 Wallis and Johnson 77. Ellner J
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300 Wallis and Johnson 113. Raad I,
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302 Wallis and Johnson 154. Anonymo
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304 Table 1 Major Fungal Infections
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306 Casadevall species suggest that
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308 Casadevall transfusions from G-
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310 Casadevall Table 3 Augmentation
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312 Casadevall There has been some
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314 Casadevall effective in achievi
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316 Casadevall CONCLUSION AND FUTUR
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318 Casadevall 16. Boutati EI, Anai
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320 Casadevall 52. Gallin JI, Malec
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322 Casadevall 91. Kowanko IC, Ferr
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324 Index Blastomycosis, see Fungal
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326 Index C-type retrovirus vectors
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328 Index K Klebsiella, intravenous
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330 Index Vaccine Recombinant vecto
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Infectious Disease IMMUNOTHERAPY FO
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Immunotherapy for Infectious Diseases

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