Immunotherapy for Infectious Diseases

Infectious Disease
IMMUNOTHERAPY FOR INFECTIOUS DISEASES
ISBN: 0-89603-669-3
humanapress.com
INFECTIOUS DISEASE
VASSIL ST. GEORGIEV, Series Editor
Immunotherapy for Infectious Diseases
Edited by
Jeffrey M. Jacobson, MD
Mount Sinai School of Medicine, New York, NY
Because the search for safe and effective chemotherapeutic agents has been hindered by antimicrobial
resistance and toxic harm, there is a growing need to understand how the immune system can be
manipulated to control infections, particularly HIV. In Immunotherapy for Infectious Diseases, Jeffrey M.
Jacobson, MD, and a group of leading researchers active in the field review the state-of-the-art for treating
various infections—particularly HIV—by manipulating the immune system’s response rather than by
using chemical drugs. The contributors synthesize the principles of immune defense on the molecular
level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine
antagonists), as well as on the cellular and clinical levels as a protection against infection. The review of
the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies,
gene therapy, and host cell–targeted approaches for treating HIV infection and restoring immune
function. Also discussed are immunotherapy for other viral infections, virus-associated malignancies,
bacterial infections and sepsis, tuberculosis, and fungal infections.
Comprehensive and cutting-edge, Immunotherapy for Infectious Diseases reviews all the current stateof-the-art
developments occurring in this rapidly evolving field and helps set the stage for the early
development of better immunologically based therapies for infections.
• State-of-the-art for treating infections by
manipulating immune system response
• Review of the basic principles of immune defense
at the molecular, cellular, and clinical levels
I Basic Principles of Immunity. Humoral Immunity. Some
Basic Cellular Immunology Principles Applied to the
Pathogenesis of Infectious Diseases. Immune Defense at
Mucosal Surfaces. II Molecular Basis for Immunotherapy.
Production of Immunoglobulins and Monoclonal Antibodies
Targeting Infectious Diseases. Dendritic Cells: Their
Role in the Immune Response to Infectious Organisms and Their
Potential Use in Therapeutic Vaccination. Cytokines, Cytokine
Antagonists, and Growth Factors for Treating Infections.
Principles of Vaccine Development. III Immunotherapy
for HIV Infection. Immunopathogenesis of HIV Infection.
Features
Contents
• Emphasis on anti-HIV immunotherapies
• Additional coverage of immunotherapy for viral,
bacterial, and fungal infections
Immune Reconstitution with Antiretroviral Chemotherapy.
Active Immunization as Therapy for HIV Infection. Passive
Immunotherapy for HIV Infection. Host Cell-Directed
Approaches for Treating HIV and Restoring Immune Function.
Gene Therapy for HIV-1 Infection. IV Immunotherapy
for Infectious Diseases Other Than HIV.
Immunotherapy for Viral Infections Other Than HIV.
Immunotherapy for Virus-Associated Malignancies. Immunotherapy
of Bacterial Infections and Sepsis. Immunotherapy
for Tuberculosis and Other Mycobacterial Infections.
Immunotherapy for Fungal Infections. Index.
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