Immunotherapy for Infectious Diseases

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Index 325 immunotherapy clinical trials, cancer, 108, 109 human immunodeficiency virus, 107, 108 infection response, Chlamydia trachomatis, 102 cytomegalovirus, 102 hepatitis B virus, 102 human immunodeficiency virus, 100, 101 human papillomavirus, 102 influenza virus, 102 Leishmania major, 101 Mycobacterium infection, 103 Toxoplasma gondii, 101 Trypanosoma cruzi, 101 markers, 103–105 ontogeny, 103, 104 prospects for research, 109 subpopulations, 104, 105 vaccines, 265 Diethylcarbamazine, fungal infection management, 310, 311 Digoxin, immunoglobulin therapy, 74 Dinitrochlorobenzene, fungal infection management, 310 DNA immunostimulatory sequences, mucosal immunity adjuvants, 50 DNA vaccine, see Vaccine E EBV, see Epstein-Barr virus Epstein-Barr virus (EBV), B-cell immortalization, 80 immune response, 181 lymphoproliferative disorders, incidence, 252 T-cell, response, 252 therapeutic transplantation, 252–254, 265–267 malignancies, adoptive immunotherapy, 265–267 nasopharyngeal carcinoma vaccination, 267 types, 251 Erlich, P., immunology contributions, 3, 4 Escherichia coli, intravenous immunoglobulin, 277, 278 F FcγΡ affinity for immunoglobulin G, 7, 8 cell distribution Fungal infection, immunocompromised host susceptibility, 305, 306 immunotherapy, adverse outcomes, 308, 315 chloroquine, 308 colony-stimulating factors, 309–313, 316 diethylcarbamazine, 308, 309 dinitrochlorobenzene, 308 fungal antigen administration, 314, 315 granulocyte transfusion, 306–308 interferon-γ, 313 interleukin-12, 315 intravenous immunoglobulin, 313 literature, 306 prospects, 316, 317 Pythium insidisum vaccine, 313, 314 specific antibody therapy, 315 transfer factor, 314 types, 303, 305 incidence trends types and risk factors G GALT, see Gut-associated lymphoreticular tissue G-CSF, see Granulocyte colonystimulating factor Gene therapy, challenges, 237 human immunodeficiency virus, animal studies, 246, 247 clinical trials, 247 combination therapies, 243 infection cycle and therapeutic targets, 237–239 protein inhibitors, CD4, 241 chemokine coreceptors, 241 single-chain antibodies, 241, 242 toxic genes, 241 transdominant negative mutants, 240, 241 retroviral vectors,
326 Index C-type retrovirus vectors, 244 challenges, 245 human immunodeficiency virusbased vectors, 244 RNA inhibitors, antisense RNA, 242 decoys, 242, 243 ribozymes, 242 GM-CSF, see Granulocyte/macrophage colony-stimulating factor Granulocyte, transfusion for fungal infection, 306–308 Granulocyte colony-stimulating factor (G-CSF), fungal infection treatment, 307–310 Granulocyte/macrophage colonystimulating factor (GM-CSF), fungal infection treatment, 307, 309, 310, 312 Gut-associated lymphoreticular tissue (GALT), see Mucosal immunity H HAART, see Highly active antiretroviral therapy Haemophilus influenzae, intravenous immunoglobulin, 277 Hepatitis B, cytokine clearance and therapy, 254 dendritic cell response, 102 immune response, 269 immunoglobulin therapy, 72, 254 liver damage, 269 vaccination, 269 Hepatocellular carcinoma, see Hepatitis B Highly active antiretroviral therapy (HAART), AIDS mortality impact, 164 historical perspective, 163, 164 humoral immunity effects, 170 immune reconstitution and consequences, 164–166, 171, 185, 186 initiation timing effects on immune reconstitution, 171 limitations, 172, 181, 222 malignancy incidence impact, 166 opportunistic infection impact, 164, 221 structured treatment interruption, 187, 188 T-cell responses, CD4+ cell blood counts, 166–168, 185, 186, 222, 226, 227 CD8+ cells, 170, 171 delayed-type hypersensitivity, 169 proliferative responses, 169, 170 viral load response, 221 Histoplasmosis, see Fungal infection HIV, see Human immunodeficiency virus Hodgkin's disease, see Epstein-Barr virus HPV, see Human papillomavirus Human immunodeficiency virus (HIV), antibody-dependent enhancement, 74 antigen-presenting cell defects, 156, 157 clades, 151 course and individual variation, 152, 153, 222, 223 cytokine response, 156 dendritic cell, immunotherapy clinical trials, 107, 108 response, 100, 101 discovery of AIDS, 151 epidemiology, 151, 152 gp41-mediated membrane fusion, 224, 225 humoral immune response, 75, 76, 182, 199 immune dysfunction, 155–157 immune exhaustion and escape, 184, 185 immunoglobulin therapy, 76–78 infection cycle, 153, 154, 237–239 inoculum size, 212 macaque model, 77, 78 major histocompatibility complex alleles and disease progression, 25, 26 opportunistic infection, see Cytomegalovirus; Fungal infection; Tuberculosis receptors, 76, 223–225 resistance, 153, 154 structure, 153, 199, 200 T-cell response, cytotoxic T-lymphocytes,
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Immunotherapy for Infectious Diseas
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In f e c t i o u s . D i s e a s e
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© 2002 Humana Press Inc. 999 River
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vi Preface I am grateful to all of
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viii Contents 11 Passive Immunother
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x Contributors BARBARA G. MATTHEWS,
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From: Immunotherapy for Infectious
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Humoral Immunity 5 Fig. 1. Humoral
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Humoral Immunity 7 Table 1 Properti
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Humoral Immunity 9 minal complement
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Humoral Immunity 11 ficity. In ligh
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Humoral Immunity 13 Fig. 7. VDJ joi
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Humoral Immunity 15 Fig. 9. Messeng
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Humoral Immunity 17 In contrast to
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Humoral Immunity 19 advantage to tr
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Humoral Immunity 21 32. Allman DM,
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Some Basic Cellular Immunology Prin
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Cellular Immunology Principles 25 i
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Cellular Immunology Principles 27 s
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Cellular Immunology Principles 29 d
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Cellular Immunology Principles 31 f
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Cellular Immunology Principles 33 F
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Cellular Immunology Principles 35 R
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Cellular Immunology Principles 37 1
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INTRODUCTION Immune Defense at Muco
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Immune Defense at Mucosal Surfaces
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II Molecular Basis for Immunotherap
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64 Kunert and Katinger IMMUNOGLOBUL
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66 Fig. 2. Monomeric, dimeric, and
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68 Kunert and Katinger Fig. 4. Humo
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70 Kunert and Katinger remove prote
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72 Kunert and Katinger Fig. 6. Diff
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74 Kunert and Katinger persons of a
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76 Kunert and Katinger that so-call
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78 Kunert and Katinger whereas sele
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80 Kunert and Katinger Different pr
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82 Kunert and Katinger HUMAN/MOUSE
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84 Kunert and Katinger are expresse
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86 Kunert and Katinger missing meta
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88 Kunert and Katinger Fig. 8. Sche
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90 Kunert and Katinger include a se
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92 Kunert and Katinger 32. Lee S, e
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94 Kunert and Katinger 72. Abbs IC,
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96 Kunert and Katinger 117. Wright
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Dendritic Cells 101 several organis
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Dendritic Cells 103 tion that infec
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Dendritic Cells 105 chaperones such
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Dendritic Cells 107 CD8� CTLs, th
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Dendritic Cells 109 complete tumor
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Dendritic Cells 111 19. Holland SM,
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Dendritic Cells 113 mouse pneumonit
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Dendritic Cells 115 dendritic cells
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INTRODUCTION Cytokines, Cytokine An
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Cytokines, Cytokine Antagonists, an
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Principles of Vaccine Development F
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Principles of Vaccine Development 1
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INTRODUCTION Immunopathogenesis of
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Immunopathogenesis of HIV Disease 1
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164 Connick counts ranged from 73 t
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166 Connick retinitis in an individ
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168 Connick A novel method of ident
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170 Connick occurs quite early in i
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172 Connick 2. Delta Coordinating C
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174 Connick 39. Hurni MA, Bohlen L,
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176 Connick 76. Dolan M.J., Clerici
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178 Connick 114. Komanduri KV, Visw
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Active Immunization for HIV Infecti
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200 Jacobson changes of gp120 alter
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202 Jacobson is reduced (54,55). A
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204 Jacobson Table 2 Potential Prot
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206 Jacobson from the SIV/17E-Cl-in
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208 Jacobson Several groups have de
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210 Jacobson HUMAN STUDIES Polyclon
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212 Jacobson clinical isolates, whi
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214 Jacobson 22. Beasley RP, Hwang
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216 Jacobson 59. Yoshiyama H, Mo H,
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218 Jacobson 95. Prince AM, Reesink
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220 Jacobson 133. Stiehm ER, Lamber
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222 Kilby and Bucy Although clinica
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224 Kilby and Bucy can infect human
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226 Kilby and Bucy the proinflammat
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228 Kilby and Bucy CD3/CD28, and th
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230 Kilby and Bucy of viral replica
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232 Kilby and Bucy 21. Cao Y, Qin L
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234 Kilby and Bucy 64. Pantaleo G,
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236 Kilby and Bucy 101. Clements-Ma
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238 Dornburg and Pomerantz cells (5
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240 Dornburg and Pomerantz Fig. 2.
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242 Dornburg and Pomerantz domains
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244 Dornburg and Pomerantz GENETIC
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246 Dornburg and Pomerantz Fig. 5.
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248 Dornburg and Pomerantz 6. Balti
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Viral Infections Other than HIV 253
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Virus-Associated Malignancies 261 c
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Virus-Associated Malignancies 263 o
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Virus-Associated Malignancies 265 I
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Virus-Associated Malignancies 267 R
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Virus-Associated Malignancies 269 T
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Virus-Associated Malignancies 271 1
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Virus-Associated Malignancies 273 5
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Page 295 and 296: 284 Wallis and Johnson replication
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Page 335: 324 Index Blastomycosis, see Fungal
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Page 343: Infectious Disease IMMUNOTHERAPY FO
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