Immunotherapy for Infectious Diseases

296 Wallis and Johnson
37. Boom WH. The role of T-cell subsets in M. tuberculosis infection. Infect Agents Dis 1996;
5:73–81.
38. Tsukaguchi K, Balaji KN, Boom WH. CD4� alpha beta T cell and gamma delta T cell
responses to M. tuberculosis. Similarities and differences in Ag recognition, cytotoxic
effector function, and cytokine production. J Immunol 1995; 154:1786–1796.
39. Nacy CA, Meltzer MS, Leonard EJ, Wyler DJ. Intracellular replication and lymphokineinduced
destruction of Leishmania tropica in C3H/HeN mouse macrophages. J Immunol
1981; 127:2381–2386.
40. Murray HW, Spitalny GL, Nathan CF. Activation of mouse peritoneal macrophages in
vitro and in vivo by interferon-gamma. J Immunol 1985; 134:1619–1622.
41. Bhardwaj N, Nash TW, Horwitz MA. Interferon-gamma-activated human monocytes inhibit
the intracellular multiplication of Legionella pneumophila. J Immunol 1986; 137:2662–2669.
42. Rook GA, Champion BR, Steele J, Varey AM, Stanford JL. I-A restricted activation by T
cell lines of anti-tuberculosis activity in murine macrophages. Clin Exp Immunol 1985;
59:414–420.
43. Flesch I, Kaufmann SH. Mycobacterial growth inhibition by interferon-gamma-activated
bone marrow macrophages and differential susceptibility among strains of M. tuberculosis.
J Immunol 1987; 138:4408–4413.
44. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme, IM. Disseminated
tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 1993; 178:2243–2247.
45. Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for
interferon gamma in resistance to M. tuberculosis infection. J Exp Med 1993;
178:2249–2254.
46. Kamijo R, Le J, Shapiro D, et al. Mice that lack the interferon-gamma receptor have profoundly
altered responses to infection with bacillus Calmette-Guérin and subsequent challenge
with lipopolysaccharide. J Exp Med 1993; 178:1435–1440.
47. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA. Multiple defects
of immune cell function in mice with disrupted interferon-gamma genes. Science 1993;
259:1739–1742.
48. Kobayashi K, Yamazaki J, Kasama T, et al. Interleukin (IL)-12 deficiency in susceptible
mice infected with M. avium and amelioration of established infection by IL-12 replacement
therapy. J Infect Dis 1996; 174:564–573.
49. Sugawara I, Yamada H, Kaneko H, Mizuno S, Takeda K, Akira S. Role of interleukin-18
(IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect Immun 1999;
67:2585–2589.
50. Holland SM, Dorman SE, Kwon A, et al. Abnormal regulation of interferon-gamma,
interleukin-12, and tumor necrosis factor-alpha in human interferon-gamma receptor
1 deficiency. J Infect Dis 1998; 178:1095–1104.
51. Frucht DM, Holland SM. Defective monocyte costimulation for IFN-gamma production
in familial disseminated M. avium complex infection: abnormal IL-12 regulation.
J Immunol 1996; 157:411–416.
52. de Jong R, Altare F, Haagen IA, et al. Severe mycobacterial and Salmonella infections in
interleukin-12 receptor-deficient patients. Science 1998; 280:1435–1438.
53. Altare F, Durandy A, Lammas D, et al. Impairment of mycobacterial immunity in human
interleukin-12 receptor deficiency. Science 1998; 280:1432–1435.
54. Kaufmann SH. Cell-mediated immunity: dealing a direct blow to pathogens. Curr Biol
1999; 9:R97–R99.
55. Stenger S, Hanson DA, Teitelbaum R, et al. An antimicrobial activity of cytolytic T cells
mediated by granulysin. Science 1998; 282:121–125.
56. Cooper AM, D’Souza C, Frank AA, Orme IM. The course of M. tuberculosis infection in
the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic
mechanisms. Infect Immun 1997; 65:1317–1320.