Immunotherapy for Infectious Diseases

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Passive Immunotherapy for HIV Infection 219 114. Andrus L, Prince AM, Bernal I, et al. Passive immunization with a human immunodeficiency virus type 1-neutralizing monoclonal antibody in Hu-PBL-SCID mice; isolation of a neutralization escape variant. J Infect Dis 1998; 177:889–897. 115. Koup RA, Safrit JT, Weir R, Gauduin M-C. Defining antibody protection against HIV-1 transmission in Hu-PBL-SCID mice. Semin Immunol 1996; 8:263–268. 116. Andrus L, McCarthy M, Cobb KE, et al. Passive immunization against HIV-1 infection. In: Girard M, Valette L (eds). Retroviruses of Human AIDS and Related Animal Diseases. Paris: Foundation Merieux, 1993, pp. 251–257. 117. Parren PW, Ditzel HJ, Gulizia RJ, et al. Protection against HIV-1 infection in hu-PBL- SCID mice by passive administration with a neutralizing monoclonal antibody against the gp120-binding site. AIDS 1995; 9:F1–F6. 118. Gauduin M-C, Parren PWHI, Weir R, Barbas CF, Burton DR, Koup RA. Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1. Nat Med 1997; 3:1389–1393. 119. Okamoto Y, Eda Y, Ogura A, et al. In SCID-hu mice, passive transfer of a humanized antibody prevents infection and atrophic change of medulla in human thymic implant due to intravenous inoculation of primary HIV-1 isolate. J Immunol 1998; 160:69–76. 120. Schutten M, Tenner-Racz K, Racz P, van Bekkum DW, Osterhaus AD. Human antibodies that neutralize primary human immunodeficiency virus type 1 in vitro do not provide protection in an in vivo model. J Gen Virol 1996; 77:1667–1675. 121. Moore JP, Nara PL. The role of the V3 loop of gp120 in HIV infection. AIDS 1994; 5:S21–S33. 122. Trkola A, Dragic T, Arthos J, et al. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature 1996; 384:184–187. 123. Gauduin M-C, Weir R, Fung MSC, Koup RA. Involvement of the complement system in antibody-mediated post-exposure protection against human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 1998; 14:205–211. 124. Jackson GG, Perkins JT, Rubenis M, et al. Passive immunoneutralization of human immunodeficiency virus in patients with advanced AIDS. Lancet 1988; 2:647–654. 125. Karpas A, Hill F, Youle M, et al. Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome. Proc Natl Acad Sci USA 1988; 85:9234–9237. 126. Busch MP, Henrard DR, Hewlett IK, et al. Poor sensitivity, specificity, and reproducibility of detection of HIV-1 DNA in serum by polymerase chain reaction. The Transfusion Safety Study Group. J Acquir Immune Defic Syndr 1992; 5:872–877. 127. Jacobson JM, Colman N, Ostrow NA, et al. Passive immunotherapy in the treatment of advanced human immunodeficiency virus infection. J Infect Dis 1993; 168:298–305. 128. Vittecoq D, Mattlinger B, Barre-Sinoussi F, et al. Passive immunotherapy in AIDS: a randomized trial of serial human immunodeficiency virus-positive transfusions of plasma rich in p24 antibodies versus transfusions of seronegative plasma. J Infect Dis 1992; 165:364–368. 129. Levy J, Youvan T, Lee ML. Passive hyperimmune plasma therapy in the treatment of acquired immunodeficiency syndrome: results of a 12 month multicenter double-blind controlled trial. Blood 1994; 84:2130–2135. 130. Vittecoq D, Chevret S, Morand-Joubert L, et al. Passive immunotherapy in AIDS: a double-blind randomized study based on transfusions rich in anti-human immundeficiency virus 1 antibodies vs transfusions of seronegative plasma. Proc Natl Acad Sci USA 1995; 92:1195–1199. 131. Morand-Joubert L, Vittecoq D, Roudot-Thoraval F, et al. Virological and immunological data of AIDS patients treated by passive immunotherapy (transfusions of plasma rich in HIV-1 antibodies). Vox Sang 1997; 73:149–154. 132. Osther K, Wiik A, Black F, et al. PASSHIV-1 treatment of patients with HIV-1 infection. A preliminary report of a phase 1 trial of hyperimmune porcine immunoglobulin to HIV-1. AIDS 1992; 6:1457–1464.
220 Jacobson 133. Stiehm ER, Lambert JS, Mofenson LM, et al. Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobin for reducing perinatal HIV transmission from HIV-infected women with advanced disease: results of Pediatric AIDS Clinical Trials Group Protocol 185. J Infect Dis 1999;179:567–575. 134. Stiehm ER, Lambert JS, Mofenson LM, et al. Use of human immunodeficiency virus (HIV) human hyperimmune immunoglobulin in HIV type 1-infected children (Pediatric AIDS Clinical Trials Group Protocol 273). J Infect Dis 2000; 181:548–554. 135. Hinkula J, Bratt G, Gilljam G, et al. Immunological and virological interactions in patients receiving passive immunotherapy with HIV-1 neutralizing monoclonal antibodies. J Acquir Immune Defic Syndr 1994; 7:940–951. 136. Gunthard HF, Gowland PL, Schupback J. A phase I/IIA clinical study with a chimeric mouse-human monoclonal antibody to the V3 loop of human immunodeficiency virus type 1 gp120. J Infect Dis 1994; 170: 1384–1393. 137. Stiehm ER, Mofenson L, Zolla-Pazner S, Jackson B, Martin NL, Ammann AJ. Summary of the workshop on passive immunotherapy in the prevention and treatment of HIV infection. The Passive Antibody Workshop Participants. Clin Immunol Immunopathol 1995; 75:84–93.
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Immunotherapy for Infectious Diseas
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In f e c t i o u s . D i s e a s e
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© 2002 Humana Press Inc. 999 River
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vi Preface I am grateful to all of
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viii Contents 11 Passive Immunother
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x Contributors BARBARA G. MATTHEWS,
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From: Immunotherapy for Infectious
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Humoral Immunity 5 Fig. 1. Humoral
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Humoral Immunity 7 Table 1 Properti
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Humoral Immunity 9 minal complement
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Humoral Immunity 11 ficity. In ligh
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Humoral Immunity 13 Fig. 7. VDJ joi
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Humoral Immunity 15 Fig. 9. Messeng
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Humoral Immunity 17 In contrast to
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Humoral Immunity 19 advantage to tr
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Humoral Immunity 21 32. Allman DM,
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Some Basic Cellular Immunology Prin
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Cellular Immunology Principles 25 i
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Cellular Immunology Principles 27 s
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Cellular Immunology Principles 29 d
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Cellular Immunology Principles 31 f
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Cellular Immunology Principles 33 F
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Cellular Immunology Principles 35 R
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Cellular Immunology Principles 37 1
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INTRODUCTION Immune Defense at Muco
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Immune Defense at Mucosal Surfaces
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II Molecular Basis for Immunotherap
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64 Kunert and Katinger IMMUNOGLOBUL
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66 Fig. 2. Monomeric, dimeric, and
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68 Kunert and Katinger Fig. 4. Humo
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70 Kunert and Katinger remove prote
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72 Kunert and Katinger Fig. 6. Diff
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74 Kunert and Katinger persons of a
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76 Kunert and Katinger that so-call
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78 Kunert and Katinger whereas sele
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80 Kunert and Katinger Different pr
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82 Kunert and Katinger HUMAN/MOUSE
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84 Kunert and Katinger are expresse
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86 Kunert and Katinger missing meta
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88 Kunert and Katinger Fig. 8. Sche
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90 Kunert and Katinger include a se
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92 Kunert and Katinger 32. Lee S, e
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94 Kunert and Katinger 72. Abbs IC,
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96 Kunert and Katinger 117. Wright
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Dendritic Cells 101 several organis
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Dendritic Cells 103 tion that infec
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Dendritic Cells 105 chaperones such
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Dendritic Cells 107 CD8� CTLs, th
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Dendritic Cells 109 complete tumor
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Dendritic Cells 111 19. Holland SM,
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Dendritic Cells 113 mouse pneumonit
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Dendritic Cells 115 dendritic cells
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INTRODUCTION Cytokines, Cytokine An
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Cytokines, Cytokine Antagonists, an
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Principles of Vaccine Development F
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Principles of Vaccine Development 1
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INTRODUCTION Immunopathogenesis of
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Immunopathogenesis of HIV Disease 1
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164 Connick counts ranged from 73 t
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166 Connick retinitis in an individ
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Page 181 and 182: 170 Connick occurs quite early in i
Page 183 and 184: 172 Connick 2. Delta Coordinating C
Page 185 and 186: 174 Connick 39. Hurni MA, Bohlen L,
Page 187 and 188: 176 Connick 76. Dolan M.J., Clerici
Page 189 and 190: 178 Connick 114. Komanduri KV, Visw
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Page 211 and 212: 200 Jacobson changes of gp120 alter
Page 213 and 214: 202 Jacobson is reduced (54,55). A
Page 215 and 216: 204 Jacobson Table 2 Potential Prot
Page 217 and 218: 206 Jacobson from the SIV/17E-Cl-in
Page 219 and 220: 208 Jacobson Several groups have de
Page 221 and 222: 210 Jacobson HUMAN STUDIES Polyclon
Page 223 and 224: 212 Jacobson clinical isolates, whi
Page 225 and 226: 214 Jacobson 22. Beasley RP, Hwang
Page 227 and 228: 216 Jacobson 59. Yoshiyama H, Mo H,
Page 229: 218 Jacobson 95. Prince AM, Reesink
Page 233 and 234: 222 Kilby and Bucy Although clinica
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Page 237 and 238: 226 Kilby and Bucy the proinflammat
Page 239 and 240: 228 Kilby and Bucy CD3/CD28, and th
Page 241 and 242: 230 Kilby and Bucy of viral replica
Page 243 and 244: 232 Kilby and Bucy 21. Cao Y, Qin L
Page 245 and 246: 234 Kilby and Bucy 64. Pantaleo G,
Page 247 and 248: 236 Kilby and Bucy 101. Clements-Ma
Page 249 and 250: 238 Dornburg and Pomerantz cells (5
Page 251 and 252: 240 Dornburg and Pomerantz Fig. 2.
Page 253 and 254: 242 Dornburg and Pomerantz domains
Page 255 and 256: 244 Dornburg and Pomerantz GENETIC
Page 257 and 258: 246 Dornburg and Pomerantz Fig. 5.
Page 259 and 260: 248 Dornburg and Pomerantz 6. Balti
Page 264 and 265: Viral Infections Other than HIV 253
Page 272 and 273: Virus-Associated Malignancies 261 c
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Virus-Associated Malignancies 269 T
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Virus-Associated Malignancies 271 1
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Virus-Associated Malignancies 273 5
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Bacterial Infections and Sepsis 277
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284 Wallis and Johnson replication
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286 Wallis and Johnson Several stud
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288 Wallis and Johnson monocytes, a
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290 Wallis and Johnson peripheral b
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292 Wallis and Johnson (A. Hise and
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294 Wallis and Johnson infections,
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296 Wallis and Johnson 37. Boom WH.
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298 Wallis and Johnson 77. Ellner J
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300 Wallis and Johnson 113. Raad I,
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302 Wallis and Johnson 154. Anonymo
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304 Table 1 Major Fungal Infections
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306 Casadevall species suggest that
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308 Casadevall transfusions from G-
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310 Casadevall Table 3 Augmentation
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312 Casadevall There has been some
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314 Casadevall effective in achievi
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316 Casadevall CONCLUSION AND FUTUR
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318 Casadevall 16. Boutati EI, Anai
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320 Casadevall 52. Gallin JI, Malec
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322 Casadevall 91. Kowanko IC, Ferr
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324 Index Blastomycosis, see Fungal
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326 Index C-type retrovirus vectors
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328 Index K Klebsiella, intravenous
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330 Index Vaccine Recombinant vecto
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Infectious Disease IMMUNOTHERAPY FO
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