Immunotherapy for Infectious Diseases
Immunotherapy for Infectious Diseases Immunotherapy for Infectious Diseases
Passive Immunotherapy for HIV Infection 215 43. Gorny MK, Moore JP, Conley AJ, et al. Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1. J Virol 1994; 68:8312–8320. 44. Cotropia J, Ugen KE, Kliks S, et al. A human monoclonal antibody to HIV-1 gp41 with neutralizing activity against diverse laboratory isolates. J Acquir Immune Defic Syndr 1996; 12:221–232. 45. Muster T, Guinea R, Trkola A, et al. Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKEAS. J Virol 1994; 68:4031–4034. 46. Trkola A, Purtscher M, Muster T, et al. Human monoclonal antibody 2G12 defines a disinctive neutalization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1. J Virol 1996; 70:1100–1108. 47. Trkola A, Pomales AB, Yuan H, et al. Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG. J Virol 1995; 69:6609–6617. 48. D’Souza MP, Milman G, Bradac JA, McPhee D, Hanson CV, Hendry RM. Neutralization of primary HIV-1 isolates by anti-envelope monoclonal antibodies. AIDS 1995; 9:867–874. 49. Laal S, Burda S, Gorny MK, Karwowska S, Buchbinder A, Zolla-Pazner S. Synergistic neutralization of human immunodeficiency type 1 by combinations of human monoclonal antibodies. J Virol 1994; 68:4001–4008. 50. Thali M, Furman C, Wahren B, et al. Cooperativity of neutralizing antibodies directed against the V3 and CD4 binding regions of the human immunodeficiency virus gp120 envelope glycoprotein. J Acquir Immune Defic Syndr 1992; 5:591–599. 51. Tilley SA, Honnen WJ, Racho ME, Chou T-C, Pinter A. Synergistic neutralization of HIV-1 by human monoclonal antibodies against the V3 loop and the CD4-binding site of gp120. AIDS Res Hum Retroviruses 1992; 8:461–467. 52. Vijh-Warrier S, Pinter A, Honnen WJ, Tilley S. Synergistic neutralization of human immunodeficiency virus type 1 by a chimpanzee monoclonal antibody against the V2 domain of gp120 in combination with monoclonal antibodies against the V3 loop and the CD4-binding site. J Virol 1996; 70:4466–4473. 53. Li A, Baba TW, Sodroski J, et al. Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulins. AIDS Res Hum Retroviruses 1997; 13:647–656. 54. Li A, Katinger H, Posner MR, et al. Synergistic neutralization of simian-human immunodeficiency virus SHIV-vpu� by triple and quadruple combinations of human monoclonal antibodies and high-titer anti-human immunodeficiency virus type 1 immunoglobulins. J Virol 1998; 72:3235–3240. 55. Mascola JR, Louder MK, Van Cott TC, et al. Potent and synergistic neutralization of human immunodeficiency (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12. J Vir 1997; 71: 7198–7206. 56. Cummins LM, Weinhold KJ, Matthews TJ, et al. Preparation and characterization of an intravenous solution of IgG from human immunodeficiency virus-seropositive donors. Blood 1991; 77:1111–1117. 57. Cavacini LA, Emes CI, Power J, et al. Human monoclonal antibodies to the V3 loop of HIV-1 gp120 mediate variable and distinct effects on binding and viral neutralization by a human monoclonal antibody to the CD4 binding site. J Acquir Immune Defic Syndr 1993; 6:6353–6358. 58. McKeating JA, Bennett J, Zolla-Pazner S, et al. Resistance of a human serum-selected human immunodeficiency virus type 1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino acid change in gp120. J Virol 1993; 67:5216–5225.
216 Jacobson 59. Yoshiyama H, Mo H, Moore JP, Ho DD. Characterization of mutants of human immunodeficiency virus type 1 that have escaped neutralization by a monoclonal antibody to the gp120 V2 loop. J Virol 1994; 68:974–978. 60. Shotton C, Arnold C, Sattentau Q, Sodroski J, McKeating JA. Identification and characterization of monoclonal antibodies specific for polymorphic antigenic determinants within the V2 region of the human immunodeficiency virus type I. J Virol 1995; 69:222–230. 61. Daar ES, Li XL, Mougdil T, Ho DD. High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates. Proc Natl Acad Sci USA 1990; 87:6574–6578. 62. Daar ES, Ho DD. Relative resistance of primary HIV-1 isolates to neutralization by soluble CD4. Am J Med 1991; 90(Suppl 4A):22S–26S. 63. Schacker T, Coombs RW, Collier AC, et al. The effects of high-dose recombinant soluble CD4 on human immunodeficiency virus type 1 viremia. J Infect Dis 1994; 169:37–40. 64. Hodges TL, Kahn JO, Kaplan LD, et al. Phase I study of recombinant human CD4immunoglobulin G therapy of patients with AIDS and AIDS-related complex. Antimicrob Agents Chemother 1991; 35:2580–2586. 65. Gauduin MC, Allaway GP, Maddon PJ, Barbas CF, Burton DR, Koup RA. Evaluation of the protective role of two recombinant immunoglobulin molecules in passive protection against primary isolates of HIV-1. Keystone Symposium: Immunopathogenesis of HIV Infection 1996; Hilton Head Island, South Carolina. 66. Dalgleish AG, Beverley PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 1984; 312:763–767. 67. Klatzman D, Champagne E, Chamaret S, et al. T-lymphocytes T4 molecule behaves as the receptor for human retrovirus LAV. Nature 1984; 312:767–768. 68. McDougal JS, Kennedy MS, Sligh JM, Cort SP, Mawle A, Nicholson JKA. (1986) Binding of HTL-III/LAV to T4� T cells by complex of the 110K viral protein and the T4 molecule. Science 1986; 231:382–385. 69. Reimann KA, Burkly LC, Burrus B, Waite BCD, Lord CI, Letvin NL. (1993) In vivo administration to rhesus monkeys of a CD-4 specific monoclonal antibody capable of blocking AIDS virus replication. AIDS Res Hum Retroviruses 1993; 9:199–207. 70. Reimann KA, Lin WU, Bixler S, et al. A humanized form of a CD4-specific monoclonal antibody exhibits decreased antigenicity and prolonged plasma half-life in rhesus monkeys while retaining its unique biological and antiviral properties. AIDS Res Hum Retroviruses 1997; 13:933–943. 71. Burkly L, Mulrey L, Blumenthal R, Dimitrov DS. Synergistic inhibition of human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion and infection by an antibody to CD4 domain 2 in combination with anti-gp120 antibodies. J Virol 1995; 69: 4267–4273. 72. Chang YW, Sawyer LSW, Murthy KK, et al. Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex. Proc Natl Acad Sci USA 1999; 96:10367–10372. 73. Olson W, Nagashima K, Tran D, et al. HIV-1 and chemokine-inhibitory activities of anti- CCR5 antibodies map to distinct CCR5 epitopes [Abstract]. In: Programs and Abstracts, 6th Conference on Retroviruses and Opportunistic Infections 1999; Chicago. 74. Murayama T, Cai Q, Rinaldo CR. Antibody-dependent cellular cytotoxicity mediated by CD16 � lymphocytes from HIV-seropositive homosexual men. Clin Immunol Immunopathol 1990; 55:297–304. 75. Ahmad A, Morriset R, Thomas R, Menezes J. Evidence for a defect of antibodydependent cellular cytotoxicity (ADCC) effector function and anti-HIV gp120/gp41specific ADCC mediating antibody titers in HIV-infected individuals. J Acquir Immune Defic Syndr 1994; 7:428–437.
- Page 175 and 176: 164 Connick counts ranged from 73 t
- Page 177 and 178: 166 Connick retinitis in an individ
- Page 179 and 180: 168 Connick A novel method of ident
- Page 181 and 182: 170 Connick occurs quite early in i
- Page 183 and 184: 172 Connick 2. Delta Coordinating C
- Page 185 and 186: 174 Connick 39. Hurni MA, Bohlen L,
- Page 187 and 188: 176 Connick 76. Dolan M.J., Clerici
- Page 189 and 190: 178 Connick 114. Komanduri KV, Visw
- Page 192 and 193: From: Immunotherapy for Infectious
- Page 194 and 195: Active Immunization for HIV Infecti
- Page 196 and 197: Active Immunization for HIV Infecti
- Page 198 and 199: Active Immunization for HIV Infecti
- Page 200 and 201: Active Immunization for HIV Infecti
- Page 202 and 203: Active Immunization for HIV Infecti
- Page 204 and 205: Active Immunization for HIV Infecti
- Page 206 and 207: Active Immunization for HIV Infecti
- Page 208: Active Immunization for HIV Infecti
- Page 211 and 212: 200 Jacobson changes of gp120 alter
- Page 213 and 214: 202 Jacobson is reduced (54,55). A
- Page 215 and 216: 204 Jacobson Table 2 Potential Prot
- Page 217 and 218: 206 Jacobson from the SIV/17E-Cl-in
- Page 219 and 220: 208 Jacobson Several groups have de
- Page 221 and 222: 210 Jacobson HUMAN STUDIES Polyclon
- Page 223 and 224: 212 Jacobson clinical isolates, whi
- Page 225: 214 Jacobson 22. Beasley RP, Hwang
- Page 229 and 230: 218 Jacobson 95. Prince AM, Reesink
- Page 231 and 232: 220 Jacobson 133. Stiehm ER, Lamber
- Page 233 and 234: 222 Kilby and Bucy Although clinica
- Page 235 and 236: 224 Kilby and Bucy can infect human
- Page 237 and 238: 226 Kilby and Bucy the proinflammat
- Page 239 and 240: 228 Kilby and Bucy CD3/CD28, and th
- Page 241 and 242: 230 Kilby and Bucy of viral replica
- Page 243 and 244: 232 Kilby and Bucy 21. Cao Y, Qin L
- Page 245 and 246: 234 Kilby and Bucy 64. Pantaleo G,
- Page 247 and 248: 236 Kilby and Bucy 101. Clements-Ma
- Page 249 and 250: 238 Dornburg and Pomerantz cells (5
- Page 251 and 252: 240 Dornburg and Pomerantz Fig. 2.
- Page 253 and 254: 242 Dornburg and Pomerantz domains
- Page 255 and 256: 244 Dornburg and Pomerantz GENETIC
- Page 257 and 258: 246 Dornburg and Pomerantz Fig. 5.
- Page 259 and 260: 248 Dornburg and Pomerantz 6. Balti
- Page 262 and 263: From: Immunotherapy for Infectious
- Page 264 and 265: Viral Infections Other than HIV 253
- Page 266 and 267: Viral Infections Other than HIV 255
- Page 268 and 269: Viral Infections Other than HIV 257
- Page 270 and 271: From: Immunotherapy for Infectious
- Page 272 and 273: Virus-Associated Malignancies 261 c
- Page 274 and 275: Virus-Associated Malignancies 263 o
216 Jacobson<br />
59. Yoshiyama H, Mo H, Moore JP, Ho DD. Characterization of mutants of human immunodeficiency<br />
virus type 1 that have escaped neutralization by a monoclonal antibody to the<br />
gp120 V2 loop. J Virol 1994; 68:974–978.<br />
60. Shotton C, Arnold C, Sattentau Q, Sodroski J, McKeating JA. Identification and characterization<br />
of monoclonal antibodies specific <strong>for</strong> polymorphic antigenic determinants within<br />
the V2 region of the human immunodeficiency virus type I. J Virol 1995; 69:222–230.<br />
61. Daar ES, Li XL, Mougdil T, Ho DD. High concentrations of recombinant soluble CD4<br />
are required to neutralize primary human immunodeficiency virus type 1 isolates. Proc<br />
Natl Acad Sci USA 1990; 87:6574–6578.<br />
62. Daar ES, Ho DD. Relative resistance of primary HIV-1 isolates to neutralization by soluble<br />
CD4. Am J Med 1991; 90(Suppl 4A):22S–26S.<br />
63. Schacker T, Coombs RW, Collier AC, et al. The effects of high-dose recombinant soluble<br />
CD4 on human immunodeficiency virus type 1 viremia. J Infect Dis 1994; 169:37–40.<br />
64. Hodges TL, Kahn JO, Kaplan LD, et al. Phase I study of recombinant human CD4immunoglobulin<br />
G therapy of patients with AIDS and AIDS-related complex. Antimicrob<br />
Agents Chemother 1991; 35:2580–2586.<br />
65. Gauduin MC, Allaway GP, Maddon PJ, Barbas CF, Burton DR, Koup RA. Evaluation of<br />
the protective role of two recombinant immunoglobulin molecules in passive protection<br />
against primary isolates of HIV-1. Keystone Symposium: Immunopathogenesis of HIV<br />
Infection 1996; Hilton Head Island, South Carolina.<br />
66. Dalgleish AG, Beverley PCL, Clapham PR, Craw<strong>for</strong>d DH, Greaves MF, Weiss RA. The<br />
CD4 (T4) antigen is an essential component of the receptor <strong>for</strong> the AIDS retrovirus.<br />
Nature 1984; 312:763–767.<br />
67. Klatzman D, Champagne E, Chamaret S, et al. T-lymphocytes T4 molecule behaves as the<br />
receptor <strong>for</strong> human retrovirus LAV. Nature 1984; 312:767–768.<br />
68. McDougal JS, Kennedy MS, Sligh JM, Cort SP, Mawle A, Nicholson JKA. (1986) Binding<br />
of HTL-III/LAV to T4� T cells by complex of the 110K viral protein and the T4 molecule.<br />
Science 1986; 231:382–385.<br />
69. Reimann KA, Burkly LC, Burrus B, Waite BCD, Lord CI, Letvin NL. (1993) In vivo<br />
administration to rhesus monkeys of a CD-4 specific monoclonal antibody capable of<br />
blocking AIDS virus replication. AIDS Res Hum Retroviruses 1993; 9:199–207.<br />
70. Reimann KA, Lin WU, Bixler S, et al. A humanized <strong>for</strong>m of a CD4-specific monoclonal<br />
antibody exhibits decreased antigenicity and prolonged plasma half-life in rhesus monkeys<br />
while retaining its unique biological and antiviral properties. AIDS Res Hum Retroviruses<br />
1997; 13:933–943.<br />
71. Burkly L, Mulrey L, Blumenthal R, Dimitrov DS. Synergistic inhibition of human immunodeficiency<br />
virus type 1 envelope glycoprotein-mediated cell fusion and infection by an<br />
antibody to CD4 domain 2 in combination with anti-gp120 antibodies. J Virol 1995; 69:<br />
4267–4273.<br />
72. Chang YW, Sawyer LSW, Murthy KK, et al. Postexposure immunoprophylaxis of primary<br />
isolates by an antibody to HIV receptor complex. Proc Natl Acad Sci USA 1999;<br />
96:10367–10372.<br />
73. Olson W, Nagashima K, Tran D, et al. HIV-1 and chemokine-inhibitory activities of anti-<br />
CCR5 antibodies map to distinct CCR5 epitopes [Abstract]. In: Programs and Abstracts,<br />
6th Conference on Retroviruses and Opportunistic Infections 1999; Chicago.<br />
74. Murayama T, Cai Q, Rinaldo CR. Antibody-dependent cellular cytotoxicity mediated by<br />
CD16 � lymphocytes from HIV-seropositive homosexual men. Clin Immunol Immunopathol<br />
1990; 55:297–304.<br />
75. Ahmad A, Morriset R, Thomas R, Menezes J. Evidence <strong>for</strong> a defect of antibodydependent<br />
cellular cytotoxicity (ADCC) effector function and anti-HIV gp120/gp41specific<br />
ADCC mediating antibody titers in HIV-infected individuals. J Acquir Immune<br />
Defic Syndr 1994; 7:428–437.