Immunotherapy for Infectious Diseases

Cytokines, Cytokine Antagonists, and Growth Factors 127
diseases a response by Th1 and Th2 cells at different time points is needed to control
or eradicate the infection. In addition, unlike in the mouse, some cytokines are synthesized
by both T-cell subsets in humans. This coproduction for some cytokines and
the redundancy in the activity of the cytokine network suggest that the immune response
to different pathogens represents a weighted response involving both T-cell subsets
rather than one limited solely to either Th1 or Th2. Therefore, it is important to recognize
that the therapeutic effect of an immunotherapy intended to manipulate the
effect of one cytokine will result not only from the modulation of that cytokine but also
the effect that that modulation has on other cytokines in the network.
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