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functional medicine and nutritional genomics - American Association ...

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AAPI’S NUTRITION GUIDE TO OPTIMAL HEALTH: USING PRINCIPLES OF FUNCTIONAL MEDICINE AND NUTRITIONAL GENOMICS<br />

systems <strong>and</strong> how they interact with each other<br />

<strong>and</strong> the surrounding environment. A systems-level<br />

underst<strong>and</strong>ing is required to underst<strong>and</strong> the whole<br />

person <strong>and</strong> his or her relationship to health or<br />

disease. A ‚nutrition physical‛ is used to identify<br />

specific signs <strong>and</strong> symptoms that provide clues to<br />

c<strong>and</strong>idate nutrients that may be insufficient in the<br />

person’s diet <strong>and</strong> contribute to compromised<br />

health. A full underst<strong>and</strong>ing of physical findings<br />

<strong>and</strong> the potential nutrient impairments <strong>and</strong> how<br />

they impact the individual on multiple levels<br />

(molecular, cellular, organs, systems <strong>and</strong><br />

networks) is essential to optimize function <strong>and</strong><br />

promote well-being.<br />

Biomarker: Biomarkers are physiological indicators<br />

derived from multiple systems <strong>and</strong> pathways that<br />

impart signals that verify health or reveal <strong>functional</strong><br />

distress. Nutritional biomarkers can be determined<br />

in saliva, blood, urine, stool, or other tissues.<br />

Some examples include salivary hormone levels,<br />

urine organic acids, stool pathogens, <strong>and</strong> nutrient<br />

levels. Laboratory assessment of biomarkers is<br />

helpful to identify <strong>functional</strong> impairments that may<br />

be amenable to <strong>nutritional</strong> therapies.<br />

Metabolic Pathways: A free flow of metabolic<br />

pathways is important for optimal human<br />

functioning. It is an orchestrated, constant, <strong>and</strong><br />

collaborative breakdown <strong>and</strong> rebuilding. An<br />

35<br />

integrative <strong>and</strong> <strong>functional</strong> <strong>medicine</strong> approach<br />

evaluates the function of the pathways <strong>and</strong><br />

determines, via biomarker analysis, the <strong>nutritional</strong><br />

support that is needed to improve metabolic<br />

performance. Pathways are generally dependent<br />

on enzymes, <strong>and</strong> enzymes have co-factors, which<br />

commonly include vitamins <strong>and</strong> minerals. An<br />

IFMNT practitioner evaluates the many<br />

repercussions due to impairments in metabolic<br />

pathways <strong>and</strong> targets <strong>nutritional</strong> therapies<br />

accordingly.<br />

Core imbalances: Core clinical imbalances underlie<br />

various disease states. These imbalances include<br />

disruptions in cellular integrity, digestion,<br />

detoxification, energy metabolism, neuro-endocrineimmune<br />

function, <strong>and</strong> <strong>nutritional</strong> status <strong>and</strong><br />

promote inflammation <strong>and</strong> oxidative stress.<br />

Multiple factors, such as pathogens, allergens,<br />

infections, <strong>nutritional</strong> insufficiencies <strong>and</strong> deficiencies,<br />

toxins, negative thoughts <strong>and</strong> beliefs, <strong>and</strong> stress,<br />

interact with genes <strong>and</strong> the environment<br />

contributing to dysfunction. Signs <strong>and</strong> symptoms<br />

arise that can be detected through a<br />

comprehensive nutrition physical <strong>and</strong> laboratory<br />

assessment. Improving balance in the individual’s<br />

environmental inputs <strong>and</strong> in the body’s fundamental<br />

physiological processes is essential to restoring<br />

health <strong>and</strong> optimizing healing.<br />

2012

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