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AAPI’S NUTRITION GUIDE TO OPTIMAL HEALTH: USING PRINCIPLES OF FUNCTIONAL MEDICINE AND NUTRITIONAL GENOMICS sports nutritionist for the Philadelphia Phillies, has consulted for the Tampa Bay Buccaneers and was the media spokesperson and columnist for the Ironman Institute. Dr. Dean is the author of Nutrition & Endurance: Where Do I Begin?, (Meyer & Meyer Publishing) and is a certified health and fitness instructor with the American College of Sports Medicine (ACSM), the Aerobics and Fitness Association of America (AFAA), and the YMCA of America. Contact Sheila Dean at Sheila@drdeannutrition.com or 727-781-4326. Website: www.DrDeanNutrition.com References: 1. Williams, R. Biochemical Individuality: The Basis for the Genetotrophic Concept. New Canaan, Connecticut. Keats Publishing.1998. 2. Human Genome Project Information. What is the Human Genome Project? Available at: http://www.ornl.gov/sci/techresources/Human_Ge nome/home.shtml. Accessed November 18, 2007. 3. Kozma C. The interface between genomics and nutrition. Top Clin Nutr. 2003;18:73-80. 4. Fogg-Johnson N. Kaput J. Nutrigenomics: an emerging scientific discipline. Food Technol. 2003;57:60-67. 5. Whitney EN, Cataldo CB, Rolfes SR. Understanding Normal and Clinical Nutrition. 5 th ed. Belmont, CA. West/Wadsworth.1998 6. Jones DS. editor. Textbook of Functional Medicine. Gig Harbor, WA. The Institute for Functional Medicine. 2005. 7. Gasche C, Scholmerich J, Brynskov J. A simple classification of Crohn’s disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis. 2000; 6: 8–15. 8. Silverberg MS, Satsangi J, Ahmad T. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005; 19 (suppl A):5–36. 98 2012 9. Crohn’s and Colitis Foundation of America. What is Crohn’s Disease? Available at: http://www.ccfa.org/info/about/crohns. Accessed November 8, 2007. 10. Motil KJ, Grand RJ. Nutritional management of inflammatory bowel disease. Pediatr Clin North Am. 1985;32:447-469. 11. Head, K. Inflammatory bowel disease part II: Crohn’s disease – pathophysiology and conventional and alternative treatment options. Altern Med Rev. 2004;9:360-401. 12. Hampe J, Cuthbert A, Croucher PJ, et al. Association between insertion mutation in NOD2 gene and Crohn’s disease in German and British populations. Lancet. 2001;357:1925–1928. 13. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature. 2001;411:599–603. 14. Yamazaki K, Takazoe M, Tanaka T. Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn’s disease. J Hum Genet. 2002;47:469–472. 15. Sugimura M, Kinouchi Y, Takahashi S, et al. CARD15/NOD2 mutational analysis in Japanese patients with Crohn’s disease. Clin Genet. 2003;63:160–162. 16. Croucher PJ, Mascheretti S, Hampe J. Haplotype structure and association to Crohn’s disease of CARD15 mutations in two ethnically divergent populations. Eur J Hum Genet. 2003;11:6–16. 17. Leong RW, Armuzzi A, Ahmad T. NOD2/CARD15 gene polymorphisms and Crohn’s disease in the Chinese population. Aliment Pharmacol Ther. 2003;17:1465–1470. 18. Inoue N, Tamura K, Kinouchi Y. Lack of common NOD2 variants in Japanese patients with Crohn’s disease. Gastroenterol. 2002;123:86–91. 19. Somerville KW, Logan RF, Edmond M, Langman MJ. Smoking and Crohn's disease. Br Med J (Clin Res Ed. 1984;289:954-956. 20. Cottone M, Rosselli M, Orlando A, et al. Smoking habits and recurrence in Crohn's disease. Gastroenterol. 1994; 106:643-648. 21. Lindberg E, Jarnerot G, Huitfeldt B. Smoking in Crohn's disease: effect on localisation and clinical course. Gut. 1992;33:779-782. 22. Lashner BA, Shaheen NJ, Hanauer SB,Kirschner BS. Passive smoking is associated with an increased risk of developing inflammatory bowel
AAPI’S NUTRITION GUIDE TO OPTIMAL HEALTH: USING PRINCIPLES OF FUNCTIONAL MEDICINE AND NUTRITIONAL GENOMICS disease in children. Am J Gastroenterol. 1993;88:356-359. 23. Persson PG, Ahlbom A, Hellers G. Inflammatory bowel disease and tobacco smoke – a casecontrol study. Gut. 1990;31:1377-1381. 24. Sonnenberg A, McCarty DJ, Jacobsen SJ. Geographic variation of inflammatory bowel disease within the United States. Gastroenterol.1991; 100:143-149. 25. Ferguson L, Shelling AN, Browning BL, Huebner C, Petermann I. Genes, diet and inflammatory bowel disease. Mut Res. 2007;622:70-83. 26. Jess T, Riis L, Jespersgaard C, Hougs L, Anderson PS, Orholm MK, Binder V, Munkholm P. Disease concordance, zygosity, and NOD2/CARD15 status: follow-up of a population-based cohort of Danish twins with inflammatory bowel disease. Am J. Gastoenterol. 2005;100:2486-2492. 27. Halfvarson J. Bresso F, D’Amato M, Jarnerot G, Pettersson S, Tysk C, CARD15/NOD2 polymorphisms do not explain concordance of Crohn’s disease in Swedish monozygotic twins. Dig Liver Dis. 2005;37:768-772. 28. MacDonald TT. Immunity, inflammation, and allergy in the gut. Science. 2005;307:1920- 1925. 29. Rescigno M, Chieppa M. Gut-level decisions in peace and war. Nat Med.2005;307:1920- 1925. 30. Vermeire S, Rutgeerts P. Antibody responses in Crohn's disease. Gastroenterol. 2004; 126:601- 604. 31. MacPherson A, Khoo UY, Forgacs I. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut. 1996;38:365-375. 32. Kidd P. Th1/Th2 Balance: the hypothesis, its limitations and implications for health and disease. Alt Med Rev. 2003:8:223-246. 33. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122:107-118. 34. Neurath MF, Finotto S, Glimcher LH. The role of the Th1/Th2 polarization in mucosal immunity. Nature Med. 2002;8:567-573. 35. Chamaillard M, Iacob R, Desreumaux P, Colombel, J. Advances and Perspectives in the Genetics of Inflammatory Bowel Diseases. Clin. Gastroenterol. Hepatol. 2006; 4:143-151. 99 2012 36. Mathew CG, Lewis CM. Genetics of inflammatory bowel disease: progress and prospects. Human Mol Genet. 2004; 13 :R161-R168. 37. Schreiber S, Rosenstiel P, Albrecht M, Hampe J, Krawczak M. Genetics of Crohn’s disease, an archetypal inflammatory barrier disease. Nat. Rev. Genet. 2005; 6:376-388. 38. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature. 2001;411:603–606. 39. Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Oene M, Cescon D, Greenbeg G, Griffiths AM, St. Geroge-Hyslop PH, Siminovitch KA. Functional variants of OCTN cation transporter genes are associated with Crohn’s disease. Nat Genet. 2004;36:471-475. 40. Stoll M, Corneliussen B, Costello CM, et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet. 2004;36:476–480. 41. Cho, Judy. Genetic Advances in Inflammatory Bowel Disease. Curr. Treat. Opt. in Gastroenterol. 2006;9:191-200. 42. Buning C, Geerdts L, Fiedler T, Gentz E, Pitre G, Reuter W, Luck W, Buhner S, Molnar T, Nagy F, Lonovics J, Dignass A, Landt O, Nickel R, Genschel J, Lochs H, Schmidt HJ, Witt H. DLG5 variants in inflammatory bowel disease. Am. J. Gastroenterol. 2006;101:786-792. 43. Inohara N, Ogura Y. Fontalba A. Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn’s disease. J Biol Chem. 2003; 278:5509-5512. 44. Girardin SE, Boneca IG, Viala J. Nod2 is a general sensor of peptidoglycan through muramyl depeptide (MDP) detaction. J Biol Chem. 2003. 278: 8869-8872. 45. Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G, Flavell RA. Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract. Science. 2005;307:731-734. 46. Erdman S. Fox JG. Dangler CA. Typhiocolitis in NF-kappa B-deficient mice. J Immunol. 2001;166:1443-1447. 47. Nakamura H, Sudo T, Tsuiki H, et al. Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55. FEBS Letters. 1998;433:63–7.
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