Primary Retinal Detachment

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Retinal Detachment Repair: Outlook for the Future 205 Fig. 10.16. Ribozyme cleavage of RNA associated with cell proliferation role of other cellular pathways in proliferation and cellular damage is being explored by many basic scientists. We have yet to take full advantage of molecular drug design to inhibit the pathways involved in PVR. Similarly, as we elucidate the roles of cytokines and develop non-toxic inhibitors of these molecules, we can use this knowledge to inhibit (Fig. 10.17). Similarly, our understanding of what damages the retina after retinal detachment and new drugs to stabilize this delicate neural tissue will be developed, which will also result in better visual outcomes, even in more long-standing macula off retinal detachment. We can now design functional peptide-based drugs and will be able to incorporate signaling peptides into nanofibers (Fig. 10.18) and engineer an instructional matrix for stem cells to replace and repopulate maculae with damaged photoreceptor elements [10]. In vivo fluorescence staining and other cell and molecular techniques are allowing us to visualize pathology in living cells as we see here, using fluorescence microscopy in vivo to follow cell motion with cytoskeletal marker staining. Understanding these fundamental processes will help prevent and treat intraocular proliferative diseases, such as PVR.
206 10 Retinal Detachment Repair: Outlook for the Future Fig. 10.17. Small molecule inhibits matrix metalloproteinase enzyme involved in angiogenesis Fig. 10.18. Cross-linked self-assembling peptide nanofibers
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Ingrid Kreissig (Ed.) Primary Retin
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Professor Dr. med. Ingrid Kreissig
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Contents 1 The History of Retinal D
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List of Contributors Gary W. Abrams
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List of Contributors XI Hermann D.
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2 Helmholz in 1850 made an accurate
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4 (vitreous, gelatin) into the ante
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6 with scleral resection that set t
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8 ditis [72-74].Temperatures up to
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10 1 The History of Retinal Detachm
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16 ion [147]. Perfluorocarbon liqui
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26 2 Prophylaxis in Fellow Eye of P
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32 found that eyes with pre-existin
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36 3 Encircling Operation with Drai
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Chapter 4 Pneumatic Retinopexy for
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Technique 57 Case Selection Proper
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Technique 59 Table 4.1. Gas charact
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Technique 61 solution; however,thes
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Technique 63 gas reflux. Following
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Complications: Prevention and Manag
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New Possibilities 67 ing on type an
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Results 69 Table 4.7 (continued) Au
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Discussion 71 surgical failures. Fa
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Discussion 73 Disadvantages of PR A
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References 75 situations, then to p
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References 77 24. Tornambe PE, Hilt
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References 79 51. Pournaras CJ, Don
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Chapter 5 Vitrectomy for the Primar
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Indications 83 Table 5.1. Indicatio
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Indications 85 Fig. 5.2. The vitreo
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Surgical Technique 87 vitrectomy an
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Outcomes 89 will be visible under a
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Outcomes 91 almost no persistent su
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References 93 7. Heimann H, Bornfel
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96 6 Minimal Segmental Buckling Wit
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98 6 Minimal Segmental Buckling Wit
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100 the operating table with the re
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102 6 Minimal Segmental Buckling Wi
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106 a b 6 Minimal Segmental Bucklin
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114 a 6 Minimal Segmental Buckling
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122 c d 6 Minimal Segmental Bucklin
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124 c Fig. 6.14c 6 Minimal Segmenta
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Table 6.1. Preoperative characteris
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Table 6.3. Final attachment after m
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130 Choroidals In 4 of the 1,462 de
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Table 6.4. Visual acuity at 2 years
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140 Probably, the future question n
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146 7 Pharmacological Approaches to
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Page 160 and 161: 152 heparin was published in eyes u
Page 162 and 163: 154 search for compounds with hepar
Page 164 and 165: 156 7 Pharmacological Approaches to
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Page 168 and 169: Chapter 8 Systematic Review of Effi
Page 170 and 171: Materials and Methods 163 Table 8.2
Page 172 and 173: Discussion 165 30% 25% 20% 15% 10%
Page 174 and 175: Discussion 167 Fig. 8.2. The small
Page 176 and 177: Conclusion 169 vitrectomy and searc
Page 178 and 179: References 171 8. Brazitikos PD, D
Page 180 and 181: References 173 34. Gunduz K, Gunalp
Page 182 and 183: References 175 63. Schepens CL (195
Page 184 and 185: 178 9 Repair of Primary Retinal Det
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Page 212 and 213: References 207 It is impossible to
Page 214 and 215: 210 C Campbell 7 case selection 57,
Page 216 and 217: 212 M Machemer 13 macular - complic
Page 218 and 219: 214 retinal - detachment - - bilate
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Primary Retinal Detachment

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