Role of Intestinal Microbiota in Ulcerative Colitis
Role of Intestinal Microbiota in Ulcerative Colitis Role of Intestinal Microbiota in Ulcerative Colitis
Preface Preface This thesis presents the studies carried out at Bioscience and Technology, National Laboratory for Sustainable Energy, Technical University of Denmark (DTU) during the years 2007‐2008 under the supervision of Associated Professor Peter Westermann and Professor Hanne Frøkiær and from the years 2008‐2011 at the Division of Microbiology and Risk Assessment, National Food Institute, DTU under the supervision of Professor Tine Rask Licht. The dynamic in vitro gut model experiments were carried out at Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Belgium. The study was supported by the Danish Strategic Research Council’s Committee on Food and Health, FøSu, Center for Biological Production of Dietary Fibers and Prebiotics, no. 2101‐06‐0067, and DTU. The present thesis is submitted towards fulfilling the requirements for obtaining the degree of Ph.D at DTU. IV
Acknowledgment Acknowledgment This thesis would not have been possible without the support of many people. First, I deeply thank my supervisor, Professor Tine Rask Licht, whose support, inspiration and enthusiastic guidance through my years of research was invaluable. Thank you for understanding me. I would also like to thank Associated Professor Peter Westermann and Professor Hanne Frøkiær for their support and engagement during the initial year of my research. I also want to thank Pieter Van den Abbeele from LabMET, Ghent University for his big help with the M‐SHIME and for making my stay in Gent enjoyable. A thanks also goes out to Professor Anne S. Meyer, Jesper Holck and Lise V. Thomassen from Bioprocess engineering, DTU for providing me with substrates and valuable discussions. I am grateful to all my current and former colleagues at the “Gut Ecology” group for creating a supportive and pleasant working atmosphere and for the nice moments we have shared. A special thanks go to the technicians Kate Vibefeldt and Bodil Madsen for their help through the experimental part of the study. Also a deep and sincerely thanks to the girls from “Office 007.” Thank you for our scientific discussions, shared laughs and for listening to me through difficult times. My warm thanks go to my parents and my fantastic sisters, Charlotte and Henriette. You have always believed in me, helped and supported me in every way possible. Thank you because you are there for me. I also wish to thank my nearest friends for happy moments and being there when needed. Last, but defiantly not least, I wish to express my deepest love and gratitude to my wonderful husband, Helge and my amazing son, Valder for their understanding, patience, support and endless love. Thank you Helge for loving me for who I am. V October 2011 Louise K. Vigsnæs
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Preface<br />
Preface<br />
This thesis presents the studies carried out at Bioscience and Technology, National Laboratory for<br />
Susta<strong>in</strong>able Energy, Technical University <strong>of</strong> Denmark (DTU) dur<strong>in</strong>g the years 2007‐2008 under the<br />
supervision <strong>of</strong> Associated Pr<strong>of</strong>essor Peter Westermann and Pr<strong>of</strong>essor Hanne Frøkiær and from the<br />
years 2008‐2011 at the Division <strong>of</strong> Microbiology and Risk Assessment, National Food Institute, DTU<br />
under the supervision <strong>of</strong> Pr<strong>of</strong>essor T<strong>in</strong>e Rask Licht.<br />
The dynamic <strong>in</strong> vitro gut model experiments were carried out at Laboratory <strong>of</strong> Microbial Ecology<br />
and Technology (LabMET), Ghent University, Belgium.<br />
The study was supported by the Danish Strategic Research Council’s Committee on Food and<br />
Health, FøSu, Center for Biological Production <strong>of</strong> Dietary Fibers and Prebiotics, no. 2101‐06‐0067,<br />
and DTU.<br />
The present thesis is submitted towards fulfill<strong>in</strong>g the requirements for obta<strong>in</strong><strong>in</strong>g the degree <strong>of</strong><br />
Ph.D at DTU.<br />
IV