Role of Intestinal Microbiota in Ulcerative Colitis
Role of Intestinal Microbiota in Ulcerative Colitis
Role of Intestinal Microbiota in Ulcerative Colitis
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Table 5: Animal studies used to demonstrate prebiotic effects <strong>in</strong> prevent<strong>in</strong>g colitis<br />
Reference<br />
(Osman et al.,<br />
2006)<br />
(Hoentjen et al.,<br />
2005)<br />
(Geier et al.,<br />
2007)<br />
(Lara‐Villoslada et<br />
al., 2006)<br />
Theoretical part<br />
(Cherbut et al.,<br />
2003)<br />
(Rodriguez‐<br />
Cabezas et al.,<br />
2010)<br />
26<br />
(Rumi et al.,<br />
2004)<br />
4. Modulation <strong>of</strong> the gut microbiota<br />
Key f<strong>in</strong>d<strong>in</strong>gs<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
Increased cecal and colonic lactobacilli and bifidobacteria<br />
Decreased IL‐1β<br />
Decreased neutrophile <strong>in</strong>filtration<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
Increased cecal and colonic lactobacilli and bifidobacteria<br />
Decreased IL‐1β<br />
Compared with colitis control, the prebiotic<br />
Increased neutrophile <strong>in</strong>filtration<br />
Did not result <strong>in</strong> greater reduction <strong>in</strong> colonic damage<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
Increased cecal and colonic lactobacilli and bifidobacteria<br />
Decreased neutrophile <strong>in</strong>filtration<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
Increased cecal and colonic lactobacilli and lactic acid bacteria<br />
Decreased neutrophile <strong>in</strong>filtration<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
Decreased neutrophile <strong>in</strong>filtration<br />
Increased colonic lactobacilli and bifidobacteria<br />
Did not affect the level <strong>of</strong> IL‐1β and TNF‐α<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
Decreased neutrophile <strong>in</strong>filtration<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
Decreased neutrophile <strong>in</strong>filtration<br />
Increased colonic lactobacilli and bifidobacteria<br />
Decreased colonic TNF‐α<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
Increased colonic TGF‐β<br />
Decreased colonic IL‐6 and IFN‐γ<br />
Compared with colitis control, the prebiotic<br />
Decreased severity <strong>of</strong> colonic damage<br />
<strong>Colitis</strong> <strong>in</strong>ducer#<br />
DSS<br />
Study design animals<br />
Spraugue‐Dawley rats (n=6 <strong>in</strong><br />
each group)<br />
Length <strong>of</strong> treatment *<br />
14 days<br />
Substrate*<br />
OFI<br />
SPF<br />
HLA B27 transgenic rats (n=8<br />
<strong>in</strong> each group)<br />
7 weeks<br />
OFI<br />
DSS<br />
Spraugue‐Dawley rats (n=8 <strong>in</strong><br />
each group)<br />
14 days<br />
FOS<br />
TNBS<br />
Wistar rats (n=20 <strong>in</strong> each<br />
group)<br />
1 month<br />
FOS<br />
TNBS<br />
Wistar rats (n=6 <strong>in</strong> each<br />
group)<br />
14 days<br />
FOS<br />
TNBS<br />
Wistar rats (n=10 <strong>in</strong> each<br />
group)<br />
14 days<br />
FOS<br />
DSS<br />
Wistar rats (n=6 <strong>in</strong> each<br />
group)<br />
14 days<br />
Lactulose<br />
(Camuesco et al.,<br />
2005)<br />
TNBS<br />
Wistar rats (n=10 <strong>in</strong> each<br />
group)<br />
3 weeks<br />
Lactulose<br />
(Kanauchi et al.,<br />
2008)<br />
CD4+CD45RB high<br />
T cells<br />
SCID mice (n=8 <strong>in</strong> each group)<br />
9 weeks<br />
GBF<br />
(Lara‐Villostada et<br />
al., 2006)<br />
GMO<br />
14 days<br />
Spraugue‐Dawley rats (n=10 <strong>in</strong> DSS<br />
each group)<br />
Decreased neutrophile <strong>in</strong>filtration<br />
*Olig<strong>of</strong>ructose‐enriched <strong>in</strong>ul<strong>in</strong> (OFI), fructo‐oligosaccharide (FOS), Germ<strong>in</strong>ated barley foodstuff (GBF), Oligosaccharides from goat milk (GMO)<br />
#Dextran sulfate sodium (DSS), pathogen‐free conditions (SPF), tr<strong>in</strong>itrobenzene sulfonic acid (TNBS)<br />
Severe comb<strong>in</strong>ed immunodeficiency (SCID)