Role of Intestinal Microbiota in Ulcerative Colitis
Role of Intestinal Microbiota in Ulcerative Colitis Role of Intestinal Microbiota in Ulcerative Colitis
List of Manuscripts Not included in this thesis Bergström, A., Licht, T.R., Wilcks, A., Grønlund, H., Andersen, J.B., Vigsnæs, L.K., and Bahl, M. The Gut Low Density Array ‘GULDA’ – A validated approach to rapid quantification of the key bacterial taxa present in intestinal samples. (2012) Paper in preparation. Vigsnæs, L.K., Nakai, H., Hemmingsen, L., Lahtinen, S., Rasmussen, L.E., Hachem, M.A., Meyer, A.S, Licht , T.R., Svensson, B. Selective in vitro growth of individual human gut bacteria on potential prebiotic oligosaccharides produced by chemoenzymatic synthesis. (2012) Paper in preparation. Vermeiren, J., Van den Abbeele, P., Laukens, D., Vigsnæs, L.K., Vos, M.D., Boon, N., and Van de Wiele, T. (2011) Decreased colonization of Clostridium cluster XIVa in an in vitro dynamic gut model during incubation of the fecal microbiota from ulcerative colitis patients. (2011) Submitted to FEMS Microbiology Ecology. DOI:10.1111/j.1574‐6941.2011.01252.x XII
Abbreviations Abbreviations AG Arabinogalactans AOS Arabino‐oligosaccharides CD Crohn’s disease DBRPC Double‐blind randomized placebo controlled DCs Dendritic cells DP Degree of polymerization DSS Dextran sulfate sodium FOS Fructo‐oligosaccharides GalA Galacturonic acid GBF Germinated barley foodstuff GH Glycoside‐hydrolases GI tract Gastrointestinal tract GMO Oligosaccharides from goat milk GOS Galacto‐oligosaccharides HG Homogalacturonan IBD Inflammatory bowel disease IECs Intestinal epithelial cells IgA Immunoglobulin A IL Interleukin LPS Lipopolysaccharides LTA Lipoteichoic acids MAMPs Microorganism‐associated molecular patterns NF‐κB Nuclear factor kappa B OFI Oligofructose‐enriched inulin PAMPs Pathogen‐associated molecular patterns PG Peptidoglycans PRRs Pattern‐recognition receptors PCA Principal Component Analysis qPCR Quantitative Real‐Time PCR RGI Rhamnogalacturonan I RGII Rhamnogalacturonan II RPC Randomized placebo controlled SCFAs Short‐chain fatty acids SCID Severe combined immune deficiency SHIME Simulator of the human intestinal microbial ecosystem SPF Pathogen free conditions TLRs Toll‐like receptors TNBS Trinitrobenzene sulfonic acid TNF‐α Tumor Necrosis Factor‐alfa Treg cells Regulatory T cells UC Ulcerative colitis XOS Xylo‐oligosaccharides XIII
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Abbreviations<br />
Abbreviations<br />
AG Arab<strong>in</strong>ogalactans<br />
AOS Arab<strong>in</strong>o‐oligosaccharides<br />
CD Crohn’s disease<br />
DBRPC Double‐bl<strong>in</strong>d randomized placebo controlled<br />
DCs Dendritic cells<br />
DP Degree <strong>of</strong> polymerization<br />
DSS Dextran sulfate sodium<br />
FOS Fructo‐oligosaccharides<br />
GalA Galacturonic acid<br />
GBF Germ<strong>in</strong>ated barley foodstuff<br />
GH Glycoside‐hydrolases<br />
GI tract Gastro<strong>in</strong>test<strong>in</strong>al tract<br />
GMO Oligosaccharides from goat milk<br />
GOS Galacto‐oligosaccharides<br />
HG Homogalacturonan<br />
IBD Inflammatory bowel disease<br />
IECs <strong>Intest<strong>in</strong>al</strong> epithelial cells<br />
IgA Immunoglobul<strong>in</strong> A<br />
IL Interleuk<strong>in</strong><br />
LPS Lipopolysaccharides<br />
LTA Lipoteichoic acids<br />
MAMPs Microorganism‐associated molecular patterns<br />
NF‐κB Nuclear factor kappa B<br />
OFI Olig<strong>of</strong>ructose‐enriched <strong>in</strong>ul<strong>in</strong><br />
PAMPs Pathogen‐associated molecular patterns<br />
PG Peptidoglycans<br />
PRRs Pattern‐recognition receptors<br />
PCA Pr<strong>in</strong>cipal Component Analysis<br />
qPCR Quantitative Real‐Time PCR<br />
RGI Rhamnogalacturonan I<br />
RGII Rhamnogalacturonan II<br />
RPC Randomized placebo controlled<br />
SCFAs Short‐cha<strong>in</strong> fatty acids<br />
SCID Severe comb<strong>in</strong>ed immune deficiency<br />
SHIME Simulator <strong>of</strong> the human <strong>in</strong>test<strong>in</strong>al microbial ecosystem<br />
SPF Pathogen free conditions<br />
TLRs Toll‐like receptors<br />
TNBS Tr<strong>in</strong>itrobenzene sulfonic acid<br />
TNF‐α Tumor Necrosis Factor‐alfa<br />
Treg cells Regulatory T cells<br />
UC <strong>Ulcerative</strong> colitis<br />
XOS Xylo‐oligosaccharides<br />
XIII
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