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Insect Control: Biological and Synthetic Agents - Index of

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206 A5: Addendum<br />

<strong>of</strong> simpler novel chemicals as insecticides. Given<br />

that more than 80% <strong>of</strong> global insecticide sales<br />

today utilize four different target sites all involving<br />

neurotransmission, there should be interest in pursuing<br />

the final goal <strong>of</strong> synthetic lig<strong>and</strong>s at the azadirachtin<br />

target site. Only then will the true<br />

potential <strong>of</strong> this novel insecticide be realized as a<br />

safe, environmentally sound pesticide for crop protection<br />

in its widest sense.<br />

References<br />

Anuradha, A., Annadurai, R.S., Shashidhara, L.S., 2007.<br />

Actin cytoskeleton as a putative target <strong>of</strong> the neem<br />

limonoid Azadirachtin A. <strong>Insect</strong> Biochem. Mol. Biol<br />

37, 627–634.<br />

Jauch, J., 2008. Natural product synthesis – total synthesis<br />

<strong>of</strong> azadirachtin – finally completed after 22 years.<br />

Angew. Chem. Int. Ed. 47, 34–37.<br />

Isman, M.B., 2006. Botanical insecticides, deterrents, <strong>and</strong><br />

repellents in modern agriculture <strong>and</strong> an increasingly<br />

regulated world. Annu. Rev. Entomol. 51, 45–66.<br />

Isman, M.B., 2008. Botanical insecticides: for richer, for<br />

poorer. Pest Manage. Sci. 64, 8–11.<br />

Mordue (Luntz), A.J., Morgan, E.D., Nisbet, A.J., 2005.<br />

Azadirachtin, a natural product in insect control.<br />

In: Gilbert, L.I, Iatrou, K., Gill, S.S. (Eds.), Comprehensive<br />

Molecular <strong>Insect</strong> Science, Vol. 6. Elsevier,<br />

Amsterdam, pp. 117–135.<br />

Morgan, E.D., 2009. Azadirachtin, a scientific gold mine.<br />

Bioorg. Med. Chem. 17, 4096–4105.<br />

Nielsen, K.L., Petersen, A.H., Emmersen, J., 2008. Deep-<br />

SAGE: Tag-based transcriptome analysis beyond microarrays.<br />

In: Janitz, M. (Ed.), Next Generation Genome<br />

Sequencing. Wiley-VCH, New York.<br />

Pravin Kumar, R., Manoj, M.N., Kush, A., Annadurai, R.S.,<br />

2007. In silico approach <strong>of</strong> azadirachtin binding with<br />

actins. <strong>Insect</strong> Biochem. Mol. Biol. 37, 635–640.<br />

Rix, U., Superti-Furga, G., 2009. Target pr<strong>of</strong>iling <strong>of</strong> small<br />

molecules by chemical proteomics. Nat. Chem. Biol. 5,<br />

616–624.<br />

Robertson, S.L., Ni, W., Dhadialla, T.S., Nisbet, A.J.,<br />

McKusker, C., Ley, S.V., Mordue, W., Mordue<br />

(Luntz), A.J., 2007. Isolation <strong>of</strong> an azadirachtinbinding<br />

complex from Drosophila Kc167 Cells. Arch.<br />

<strong>Insect</strong> Biochem. Physiol. 64, 200–208.<br />

Veitch, G.E., Beckmann, E., Burke, Boyer, A., Maslen, S.L.,<br />

Ley, S.V., 2007a. Synthesis <strong>of</strong> azadirachtin: a long<br />

but successful journey. Angew. Chem. Int. Ed. 46,<br />

7629–7632.<br />

Veitch, G.E., Beckmann, E., Burke, Boyer, A., Ayats, C.,<br />

Ley, S.V., 2007b. A relay route for the synthesis <strong>of</strong><br />

azadirachtin. Angew. Chem. Int. Ed. 46, 7633–7635.

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