UNIVERSITY OF CALIFORNIA, SAN DIEGO

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2 CALIFORNIA, SAN DIEGO K. F. Boersma, D. J. Jacob, E. J. Buscela, A. E. Perring, R. nior Research Fellow, 1958, California Institute of Tech- dynamics. Charge exchange and dissociative recombina- Dirsken, R. J. can der, A. R. M. Yantosca, R. J. Park, M. O. nology. Ion-molecule reactions in the gas phase; organo- tion dynamics of molecular and cluster cations. TEL: Wenig, T. H. Bertram and R. C. Cohen, Validation of OMI sulfur chemistry; reaction mechanisms. TEL: (619) 534- (858) 534-5559 FAX: (858) 534-9856 Tropospheric NO2 observations during INTEX-B and appli- 3130 FAX: (619) 534-5211 Web: checont6.ucsd.edu cation to constrain NOx emissions over the Eastern United Email: mcaserio@ucsd.edu Email: rcontinetti@ucsd.edu States and Mexico, Atmos. Environment, (2008). O. R. Cooper, S. Eckhardt, J. H. Crawford, C. C. Brown, No publication information submitted for this edition. Zhou Lu, Qichi Hu, Jonathan E. Oakman and Robert E. R. C. Cohen, T. H. Bertram, P. Wooldridge, A. Perring, W. Continetti, Dynamics on the HOCO potential energy surface CLARK, LEIGH B. (b.1934) Professor Emeritus. B.S, studied by dissociative photodetachment of HOCO- H. Brune, X. Ren, D. Brunner and S. Baughcum, The sum- and DOCO-, mertime buildup and decay of lightning NOx and aged thun- 1957, University of California, Berkeley; Ph.D, 1963, J. Chem. Phys, 126, 194305/1-194305/11 (2007). derstorm outflow above North America, J. Geophys. Res, University of Washington. Research Fellowship, 1963, Silvia De Dea, Dominic Graziani, David R. Miller and (2008). University of California, Berkeley. Electronic states of Robert E. Continetti, Growth of magnetic thin films using molecules; exciton states of crystals; reflection spectros- CO2 RESS expansions, J. Supercrit. Fluids, 42, 410-418 BOND, F. THOMAS copy; optical properties of polynucleotides; optical prop- (2007). No publication information submitted for this edition. erties of liquids. TEL: (619) 534-2156 Zhou Lu and Robert E. Continetti, Alignment of a Molecu- Email: lclark@ucsd.edu lar Anion via a Shape Resonance in Near-Threshold Photodetachment, Phys. Rev. Lett, 99, 113005/1-113005/4 (2007). BRYDGES, STACEY (b.1972) Lecturer, Potential Se- No publication information submitted for this edition. Jennifer E. Mann, Zhen Xie, John D. Savee, Bastiaan J. curity of Employment (LPSOE). B.Sc, 1996, McMaster University; Ph.D, 2003, McMaster University. Chemistry COHEN, SETH M. (b.1972) Associate Professor. B.S, Braams, Joel M. Bowman and Robert E. Continetti, Probing the Structure of CH5 + Education. TEL: (858) 246-0993 FAX: (858) 534-7042 Web: www-chem.ucsd.edu/research/profile.cfm?cid= C22509 Email: sbrydges@ucsd.edu No publication information submitted for this edition. 1994, Stanford University; B.A, 1994, Stanford University; Ph.D, 1998, University of California, Berkeley. NIH Postdoctoral Fellow, 1999-2001, M. I. T. Bioinorganic Chemistry; Inorganic Chemistry. Metalloenzyme inhibitor design, metal-organic frameworks. TEL: (858) 822- 5596 FAX: (858) 822-5598 by Dissociative Charge Exchange, J. Am. Chem. Soc, 130, 3730-3731 (2008). Vadim A. Mozhayskiy, John D. Savee, Jennifer E. Mann, Robert E. Continetti and Anna I. Krylov, Conical for Stepwise, Glancing for Concerted: The Role of the Excited-State Topology in the Three-Body Dissociation of sym-Triazine, J. Phys. Chem. A, 112, 12345-12354 (2008). BURKART, MICHAEL D. (b.1972) Associate Professor. B.A, 1994, Rice University; Ph.D, 1999, The Scripps Research Institute. NIH Postdoctoral Fellow, 1999-2002, Harvard Medical School. Bioorganic Chemistry. Bioorganic chemistry; natural product biosynthesis; natural product synthesis; molecular diagnostics. TEL: Web: www.checohen0.ucsd.edu/ Email: scohen@ucsd.edu Publication list has not been verified by the department. Sergio J. Garibay, Jay R. Stork, Zhenqiang Wang, Seth M. Cohen and Shane G. Telfer, Enantiopure vs. racemic metalloligands: impact on metal-organic framework structure and Silvia De Dea, David R. Miller and Robert E. Continetti, Growth of Nanoscale Magnetic Films Using a Supercritical CO2/Ferric Acetylacetonate Batch Process Near Room Temperature, J. Phys. Chem. C, 112, 17102-17108 (2008). Zhou Lu, Jonathan E. Oakman, Qichi Hu and Robert E. Continetti, Photoelectron-photofragment angular correlations in the dissociative photodetachment of HOCO- (858) 534-5673 FAX: (858) 822-2182 Web: www-chem.ucsd.edu/research/profile.cfm?cid= C04373 Email: mburkart@ucsd.edu K. M. Clarke, A. C. Mercer, J. J. La Clair and M. D. Burkart, In vivo reporter labeling of proteins via metabolic deliv- ery of Coenzyme A Analogues, J. Am. Chem. Soc, 127, 11234-11235 (2005). M. D. Alexander, S. D. Fontaine, J. J. La Clair, A. G. Di- Pasquale, A. L. Rheingold and M. D. Burkart, Synthesis of the mycolactone core by ring-closing metathesis, Chem. Comm, 44, 4602-4604 (2006). Andrew S. Worthington and Michael D. Burkart, The old is new again: Asparagine oxidation in calcium-dependent antibiotic biosynthesis, ACS Chem. Biol, 2, 152-154 (2007). Alexander L. Mandel, Brian D. Jones, James J. La Clair and Michael D. Burkart, A synthetic entry to pladienolide B and FD-895, Bioorg. Med. Chem. Lett, 17, 5159-5164 (2007). Timothy L. Foley and Michael D. Burkart, Site-specific protein modification: Advances and applications, Curr. Opin. Chem. Biol, 11, 12-19 (2007). Andrew C. Mercer and Michael D. Burkart, The ubiquitous carrier protein-a window to metabolite biosynthesis, Nat. Prod. Rep, 24, 750-773 (2007). Peyman Najmabadi, James J. La Clair and Michael D. Burkart, A systems perspective to digital structures in molecular analysis, Org. Biomol. Chem, 5, 214-222 (2007). A. C. Mercer, J. L. Meier, G. H. Hur, A. R. Smith and M. D. Burkart, Antibiotic evaluation and in vivo analysis of alkynyl Coenzyme A antimetabolites in Escherichia coli, Bioorg Med Chem Lett, 18, 5991-5994 (2008). Shiven Kapur, Andrew Worthington, Yinyan Tang, David E. Cane, Michael D. Burkart and Chaitan Khosla, Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase, Bioorg. Med. Chem. Lett, 18, 3034-3038 (2008). Robert W. Haushalter, Andrew S. Worthington, Gene H. Hur and Michael D. Burkart, An orthogonal purification strategy for isolating crosslinked domains of modular synthases, Bioorg. Med. Chem. Lett, 18, 3039-3042 (2008). A. S. Worthington, G. H. Hur, J. L. Meier, Q. Cheng, B. S. Moore and M. D. Burkart, Probing the compatibility of type II ketosynthase-carrier protein partners, Chembiochem, 9, 2096-2103 (2008). Jordan L. Meier, Andrew C. Mercer and Michael D. Burkart, Fluorescent Profiling of Modular Biosynthetic Enzymes by Complementary Metabolic and Activity Based Probes, J. Am. Chem. Soc, 130, 5443-5445 (2008). J. L. Meier, T. Barrows-Yano, T. L. Foley, C. L. Wike and M. D. Burkart, The unusual macrocycle forming thioesterase of mycolactone, Mol Biosyst, 4, 663-671 (2008). Alexander Mandel, Synthetic studies applied to polyketide natural products. (D) Andrew Mercer, Co-opting CoA biosynthesis for the in vivo modification of carrier proteins. (D) Andrew Worthington, Chemoenzymatic investigations of protein-protein interactions in carrier protein-mediated biosynthesis. (D) synthesis, Chem. Commun. (Cambridge, U. K.), 4881-4883 (2007). Faith E. Jacobsen, Jana A. Lewis and Seth M. Cohen, The design of inhibitors for medicinally relevant metalloproteins, ChemMedChem, 2, 152-171 (2007). Seth M. Cohen, New approaches for medicinal applications of bioinorganic chemistry, Curr. Opin. Chem. Biol, 11, 115-120 (2007). Sara R. Halper, Jay R. Stork and Seth M. Cohen, Preparation and characterization of asymmetric �-alkoxy dipyrrin ligands and their metal complexes, Dalton Trans, 1067-1074 (2007). Jay R. Stork, Van S. Thoi and Seth M. Cohen, Rare Examples of Transition-Metal-Main-Group Metal Heterometallic Metal-Organic Frameworks from Gallium and Indium Dipyr- rinato Complexes and Silver Salts: Synthesis and Framework Variability, Inorg. Chem. (Washington, DC, U. S.), 46, 11213-11223 (2007). Faith E. Jacobsen, Jana A. Lewis, Katie J. Heroux and Seth M. Cohen, Characterization and evaluation of pyrone and tropolone chelators for use in metalloprotein inhibitors, Inorg. Chim. Acta, 360, 264-272 (2007). Zhenqiang Wang and Seth M. Cohen, Postsynthetic Covalent Modification of a Neutral Metal-Organic Framework, J. Am. Chem. Soc, 129, 12368-12369 (2007). Stephane Petoud, Gilles Muller, Evan G. Moore, Jide Xu, Jurek Sokolnicki, James P. Riehl, Uyen N. Le, Seth M. Cohen and Kenneth N. Raymond, Brilliant Sm, Eu, Tb, and Dy Chiral Lanthanide Complexes with Strong Circularly Polarized Luminescence, J. Am. Chem. Soc, 129, 77-83 (2007). Misha Golynskiy, Sheng Li, Virgil L. Woods, Jr. and Seth M. Cohen, Conformational studies of the manganese transport regulator (MntR) from Bacillus subtilis using deuterium exchange mass spectrometry, JBIC, J. Biol. Inorg. Chem, 12, 699-709 (2007). Yi-Long Yan and Seth M. Cohen, Efficient Synthesis of 5- Amido-3-hydroxy-4-pyrones as Inhibitors of Matrix Metalloproteinases, Org. Lett, 9, 2517-2520 (2007). Zhenqiang Wang and Seth M. Cohen, Tandem modification of metal-organic frameworks by a postsynthetic approach, Angew. Chem., Int. Ed, 47, 4699-4702 (2008). Emily Dugan, Zhenqiang Wang, Marilyn Okamura, Annette Medina and Seth M. Cohen, Covalent modification of a metal-organic framework with isocyanates: probing substrate scope and reactivity, Chem. Commun. (Cambridge, U. K.), 3366-3368 (2008). Arpita Agrawal, Diego Romero-Perez, Jennifer A. Jacob- sen, Francisco J. Villarreal and Seth M. Cohen, Zinc-binding groups modulate selective inhibition of MMPs, ChemMed- Chem, 3, 812-820 (2008). Van S. Thoi, Jay R. Stork, Edwards T. Niles, Ezra C. Depperman, David L. Tierney and Seth M. Cohen, Diamidodi- pyrrins: Versatile Bipyrrolic Ligands with Multiple Metal Binding Modes, Inorg. Chem. (Washington, DC, U. S.), 47, 10533-10541 (2008). Kristine K. Tanabe, Zhenqiang Wang and Seth M. Cohen, Systematic Functionalization of a Metal-Organic Framework via a Postsynthetic Modification Approach, J. Am. Chem. Soc, 130, 8508-8517 (2008). , Mol. Phys, 106, 595-606 (2008). John D. Savee, Vadim A. Mozhayskiy, Jennifer E. Mann, Anna I. Krylov and Robert E. Continetti, The Role of Excited-State Topology in Three-Body Dissociation of sym-Triazine, Science (Washington, DC, U. S.), 321, 826-830 (2008). J. E. Mann, Probing the potential energy surface of elementary neutral reactions using dissociative charge exchange. (D) S. De Dea, Nano-scale magnetic film formation by decom- pression of supercritical CO2/ferric acetylacetonate solutions. (D) Z. Lu, Dynamics of gas phase transient species studied by dissociative photodetachment of molecular anions. (D) CROWELL, JOHN E. (b.1956) Professor. B.S, 1979, University of Illinois, Urbana; Ph.D, 1984, University of California, Berkeley. Postdoctoral Research Associate, 1984-1986, University of Pittsburgh. Bioanalytical Chemistry; Physical Chemistry. Spectroscopic studies of surface chemistry at well-defined interfaces and surfaces; kinetic and mechanistic studies of elementary surface processes, thin film growth by atomic layer deposition, chemical vapor deposition, and photo-induced surface chemistry; development of in-situ spectroscopic probes of surface reactions; surface infrared spectroscopy; de- sorption / ionization mass spectrometry; nanofunctionalization and patterning for bioanalysis; microfluidics, pro- teomics and microanalysis. TEL: (858) 534-5441 FAX: (858) 534-7244 Web: www-chem.ucsd.edu/research/profile.cfm?cid= C00906 Email: jcrowell@ucsd.edu No publication information submitted for this edition. CZWORKOWSKI, JOHN (b.1963) Lecturer PSOE. B.A, 1985, University of Pennsylvania; Ph.D, 1991, Uni- versity of Texas at Austin. Postdoctoral Associate, 1991- 1996, Yale University; Associate Research Scientist, 1996-1998, Yale University. Chemistry Education. TEL: (858) 822-6665 FAX: (858) 534-7687 Web: www-chem.ucsd.edu/research/profile.cfm?cid= C20691 Email: jczworkowski@ucsd.edu No publication information submitted for this edition. DENNIS, EDWARD A. (b.1941) Professor. B.A, 1963, Yale University; M.A, 1965, Harvard University; Ph.D, 1968, Harvard University; Ph.D.(Hon.), 2008, Goethe University of Frankfurt Germany. Research Fellowship, 1967-1969, Harvard Medical School. Biochemistry; Pharmacology. Phospholipases-catalytic mechanism, regulation function and mutagenesis; prostaglandin control in macrophage cell cultures; phospholipid metabolism and enzyme mechanism; NMR of phospholipids; membrane and micelle structure and function; signal Jordan Meier, Synthetic active site probes for PKS and CONTINETTI, ROBERT E. (b.1962) Professor. transduction; LIPID MAPS; mass spec of lipids and pro- NRPS biosynthetic enzymes. (D) B.A, 1983, John Hopkins University; Ph.D, 1989, Uni- teins. TEL: (858) 534-3055 FAX: (858) 534-7390 versity of California, Berkeley. Postdoctoral Fellowship, Web: www.cobra.uscd.edu CASERIO, MARJORIE C. (b.1929) Professor Emer- 1989-1992, University of California, Berkeley. Chemical Email: edennis@ucsd.edu itus. B.Sc, 1950, Chelsea College, University of London; Physics; Physical Chemistry. Energetics and dissociation Matthew W. Buczynski, Daren L. Stephens, Rebecca C. M.A, 1951, Bryn Mawr College, Pennsylvania; Ph.D, dynamics of reactive intermediates; photodissociation Bowers-Gentry, Andrej Grkovich, Raymond A. Deems and 1956, Bryn Mawr College, Pennsylvania. Postdoctoral and photodetachment dynamics; photoelectron-photo- Edward A. Dennis, TLR-4 and Sustained Calcium Agonists Fellowship, 1956, California Institute of Technology; Se- fragment coincidence spectroscopy; three-body reaction Synergistically Produce Eicosanoids Independent of Protein
CALIFORNIA, SAN DIEGO 3 Synthesis in RAW264.7 Cells, J. Biol. Chem, 282, 22834- Oswald Quehenberger, Aaron Armando, Darren Dumlao, rin-related phosphatase Mtmr13 leads to a Charcot-Marie- 22847 (2007). Daren Stephens and Edward A. Dennis, Lipidomics analysis Tooth 4B2-like peripheral neuropathy in mice, Proc. Natl. Richard Harkewicz, Eoin Fahy, Alexander Andreyev and of essential fatty acids in macrophages, Prostaglandins Leu- Acad. Sci. U. S. A, 105, 4916-4921 (2008). Edward A. Dennis, Arachidonate-derived Dihomoprostaglan- kotrienses and Essential Fatty Acids, 79, 123-129 (2008). Shaun W. Lee, Douglas A. Mitchell, Andrew L. Markley, din Production Observed in Endotoxin-stimulated Macrophage-like Cells, J. Biol. Chem, 282, 2899-2910 (2007). Richard Harkewicz, Eoin Fahy, Alexander Andreyev and Edward A. Dennis, Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells. [Erratum to document cited in CA146: 314968], J. Biol. Chem, 282, 29068 (2007). David A. Six, Efrosini Barbayianni, Vassilios Loukas, Violetta Constantinou-Kokotou, Dimitra Hadjipavlou-Litina, Daren Stephens, Alan C. Wong, Victoria Magrioti, Panagiota Moutevelis-Minakakis, Sharon F. Baker, Edward A. Dennis and George Kokotos, Structure-Activity Relationship of 2- Oxoamide Inhibition of Group IVA Cytosolic Phospholipase A2 and Group V Secreted Phospholipase A2, J. Med. Chem, 50, 4222-4235 (2007). Panagiota Moutevelis-Minakakis, Afroditi Neokosmidi, Maria Filippakou, Daren Stephens, Edward A. Dennis and George Kokotos, Synthesis of lipophilic 2-oxoamides based on �-aminobutyric and �-aminovaleric analogues and their activity against phospholipase A2, J. Pept. Sci, 13, 634-641 (2007). Kara Schmelzer, Eoin Fahy, Shankar Subramaniam and Edward A. Dennis, The lipid maps initiative in lipidomics, Methods Enzymol, 432, 171-183 (2007). Raymond Deems, Matthew W. Buczynski, Rebecca Bowers-Gentry, Richard Harkewicz and Edward A. Dennis, Detection and quantitation of eicosanoids via high performance liquid chromatography-electrospray ionization-mass spectrometry, Methods Enzymol, 432, 59-82 (2007). Manish Sud, Eoin Fahy, Dawn Cotter, Alex Brown, Edward A. Dennis, Christopher K. Glass, Alfred H. Merrill, Jr., Robert C. Murphy, Christian R. H. Raetz, David W. Russell and Shankar Subramaniam, LMSD: LIPID MAPS structure database, Nucleic Acids Res, 35, D527-D532 (2007). John E. Burke, Mark J. Karbarz, Raymond A. Deems, Sheng Li, Virgil L. Woods, Jr. and Edward A. Dennis, Interaction of Group IA Phospholipase A2 with Metal Ions and Phospholipid Vesicles Probed with Deuterium Exchange Mass Spectrometry, Biochemistry, 47, 6451-6459 (2008). Georgia Antonopoulou, Efrosini Barbayianni, Victoria Magrioti, Naomi Cotton, Daren L. Stephens, Violetta Constantinou-Kokotou, Edward A. Dennis and George Kokotos, Structure-activity relationships of natural and non-natural amino acid-based Amide and 2-oxoamide inhibitors of human Phospholipase A2 enzymes, Bioorg.Med.Chem, 16, 10257-10269 (2008). Ruben Lopez-Vales, Xavier Navarro, Takao Shimizu, Con- Andrej Grkovich, The function, activation and inhibition of phosphatidic acid phosphohydrolase-1 and group IVA phospholipase A2 in toll-like receptor activated macrophages. (D) John E. Burke, Deuterium exchange mass spectrometry studies of the phospholipase A2 superfamily. (D) Matthew W. Buczynski, Lipidomic analysis of eicosanoid synamics in inflammation and disease. (D) DIXON, JACK E. (b.1943) Professor. B.A, 1966, University of California, Los Angeles; Ph.D, 1971, Universi- ty of California, Santa Barbara. TEL: (858) 822-3522 FAX: (858) 822-0084 Email: jedixon@ucsd.edu Publication list has not been verified by the department. Seema Mattoo, Yvonne M. Lee and Jack E. Dixon, Interactions of bacterial effector proteins with host proteins, Curr. Opin. Immunol, 19, 392-401 (2007). Alan Cheng, Mei Zhang, Matthew S. Gentry, Carolyn A. Worby, Jack E. Dixon and Alan R. Saltiel, A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori’s disease, Genes Dev, 21, 2399-2409 (2007). Sandra E. Wiley, Mark L. Paddock, Edward C. Abresch, Larry Gross, Peter van der Geer, Rachel Nechushtai, Anne N. Murphy, Patricia A. Jennings and Jack E. Dixon, The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster, J. Biol. Chem, 282, 23745- 23749 (2007). Neal M. Alto, Andrew W. Weflen, Matthew J. Rardin, Defne Yarar, Cheri S. Lazar, Raffi Tonikian, Antonius Koller, Susan S. Taylor, Charles Boone, Sachdev S. Sidhu, Sandra L. Schmid, Gail A. Hecht and Jack E. Dixon, The type III effector EspF coordinates membrane trafficking by the spa- tiotemporal activation of two eukaryotic signaling pathways, J. Cell Biol, 178, 1265-1278 (2007). Matthew S. Gentry, Robert H. Dowen, III, Carolyn A. Worby, Seema Mattoo, Joseph R. Ecker and Jack E. Dixon, The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease, J. Cell Biol, 178, 477-488 (2007). Lorena Navarro, Antonius Koller, Roland Nordfelth, Hans Wolf-Watz, Susan Taylor and Jack E. Dixon, Identification of a molecular target for the Yersinia protein kinase A, Mol. Cell, 26, 465-477 (2007). Shibu Yooseph, Granger Sutton, Douglas B. Rusch, Aaron L. Halpern, Shannon J. Williamson, Karin Remington, Jona- Mary E. Hensler, David Gonzalez, Aaron Wohlrab, Pieter C. Dorrestein, Victor Nizet and Jack E. Dixon, Discovery of a widely distributed toxin biosynthetic gene cluster, Proc. Natl. Acad. Sci. U. S. A, 105, 5879-5884 (2008). Hirohide Iwasaki, Yoshimichi Murata, Youngjun Kim, Is- rail Hossain, Carolyn A. Worby, Jack E. Dixon, Thomas McCormack, Takehiko Sasaki and Yasushi Okamura, A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate, Proc. Natl. Acad. Sci. U. S. A, 105, 7970- 7975 (2008). DONOGHUE, DANIEL J. (b.1952) Professor. B.Sc, 1974, University of Wisconsin; Ph.D, 1979, M.I.T. Postdoctoral Fellowship, 1980-1982, Salk Institute. Molecular Biology. FGFR2 signaling and FGFR3 activation of MCF-7 in breast cancer. Nordihydroguaiaretic acid (NDGA) and FGFR3 in multiple myeloma cells FGFR4 signaling and NF-kappaB regulation in prostate cancer. Androgen-Independence (AI) cell proliferation, and acquisition of invasiveness and metastatic properties in prostate cancer cells. Spy1 interaction with p27 and CDK2 in cell cycle progression, DNA damage, apoptosis, and checkpoint activation. TEL: (858) 534-2463 FAX: (858) 534-7481 Web: cancer.ucsd.edu/summaries/ddonoghue.asp Email: ddonoghue@ucsd.edu Randy F. Gastwirt, Christopher W. McAndrew and Daniel J. Donoghue, Speedy/RINGO regulation of CDKs in cell cycle, checkpoint activation and apoptosis, Cell Cycle, 6, 1188- 1193 (2007). Christopher W. McAndrew, Randy F. Gastwirt, April N. Meyer, Lisa A. Porter and Daniel J. Donoghue, Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27, Cell Cycle, 6, 1937-1945 (2007). Azadeh Golipour, Dorothy Myers, Tiffany Seagroves, Daniel Murphy, Gerard I. Evan, Daniel J. Donoghue, Roger A. Moorehead and Lisa A. Porter, The Spy1/RINGO Family Represents a Novel Mechanism Regulating Mammary Growth and Tumorigenesis, Cancer Res, 68, 3591-3600 (2008). April N. Meyer, Christopher W. McAndrew and Daniel J. Donoghue, Nordihydroguaiaretic Acid Inhibits an Activated Fibroblast Growth Factor Receptor 3 Mutant and Blocks Downstream Signaling in Multiple Myeloma Cells, Cancer Res, 68, 7362-7370 (2008). stantinos Baskakis, George Kokotos, Violetta Constantinou- Kokotou, Daren L. Stephens, Edward A. Dennis and Sameul David, Intracellular Phospholipase A2 group IVA and group than A. Eisen, Karla B. Heidelberg, Gerard Manning, Weizhong Li, Lukasz Jaroszewski, Piotr Cieplak, Christopher S. Miller, Huiying Li, Susan T. Mashiyama, Marcin P. Joachim- Randy Francis Gastwirt, Spy1 regulation of the cell cycle, checkpoint activation and apoptosis. (D) VIA play important roles in wallerian degeneration and axon regeneration after peripheral nerve injury, Brain, 131, 2620iak, Christopher van Belle, John-Marc Chandonia, David A. Soergel, Yufeng Zhai, Kannan Natarajan, Shaun Lee, Benja- DOOLITTLE, RUSSELL F. (b.1931) Research Pro- 2631 (2008). Faith E. Jacobsen, Mathew W. Buczynski, Edward A. Dennis and Seth M. Cohen, A macrophage cell model for selective metalloprotein inhibitor design, Chem.Bio.Chem, 9, 2087-2095 (2008). Georgia Antonopoulou, Victoria Magrioti, Daren L. Stephens, Violetta Constantinou-Kokotou, Edward A. Dennis and George Kokotos, Synthesis of 2-oxoamides based on sulfonamide analogues of gamma-amino acids and their activity on min J. Raphael, Vineet Bafna, Robert Friedman, Steven E. Brenner, Adam Godzik, David Eisenberg, Jack E. Dixon, Susan S. Taylor, Robert L. Strausberg, Marvin Frazier and J. Craig Venter, The Sorcerer II global ocean sampling expedition: expanding the universe of protein families, PLoS Biol, 5, 432-466 (2007). Mark L. Paddock, Sandra E. Wiley, Herbert L. Axelrod, Aina E. Cohen, Melinda Roy, Edward C. Abresch, Dominique Capraro, Anne N. Murphy, Rachel Nechushtai, Jack E. fessor. B.A, 1952, Wesleyan University; M.A, 1957, Trinity College; Ph.D, 1961, Harvard University. Post- doctoral Fellowship, 1962-1964, Karolinska Institute. Structure and function of fibrinogen; fibrin formation. Evolution of proteins; peptide synthesis; x-ray crystallography. TEL: (858) 534-4417 Email: rdoolittle@ucsd.edu Publication list has not been verified by the department. Phospholipase A2, J Pept Sci, 10, 1111-1120 (2008). John E. Burke, Yuan-Hao Hsu, Raymond A. Deems, Sheng Li, Virgil L. Woods Jr. and Edward A. Dennis, A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic Phospholipase A2, J. Biol Chem, 283, 31227-31236 (2008). Yuan-Hao Hsu, John E. Burke, Daren L. Stephens, Raymond A. Deems, Sheng Li, Kyle M. Asmus, Virgil L. Woods Jr. and Edward A. Dennis, Calcium binding rigidifies the C2 domain of GIVA Phospholipase A2 as revealed by hydrogen/ deuterium exchange mass spectrometry, J. Biol Chem, 283, 9820-9827 (2008). Richard Harkewicz, Karsten Hartvigsen, Felicidad Almazan, Edward A. Dennis, Joseph L. Witztum and Yury I. Miller, Cholesteryl Ester Hydroperoxides Are Biologically Active Components of Minimally Oxidized Low Density Lipoprotein, J. Biol. Chem, 283, 10241-10251 (2008). Dixon and Patricia A. Jennings, MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone, Proc. Natl. Acad. Sci. U. S. A, 104, 14342-14347 (2007). Sandra E. Wiley, Anne N. Murphy, Stuart A. Ross, Peter van der Geer and Jack E. Dixon, MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity, Proc. Natl. Acad. Sci. U. S. A, 104, 5318- 5323 (2007). Youngjun Kim, Matthew S. Gentry, Thurl E. Harris, Sandra E. Wiley, John C. Lawrence, Jr. and Jack E. Dixon, A conserved phosphatase cascade that regulates nuclear membrane biogenesis, Proc. Natl. Acad. Sci. U. S. A, 104, 6596- 6601 (2007). Seema Mattoo, Neal M. Alto and Jack E. Dixon, Subver- sion of myosin function by E. coli, Dev. Cell, 14, 8-10 (2008). Stephen J. Juris, Kavita Shah, Kevan Shokat, Jack E. Dix- Russell F. Doolittle and Leela Pandi, Probing the �-Chain Hole of Fibrinogen with Synthetic Peptides That Differ at Their Amino Termini, Biochemistry, 46, 10033-10038 (2007). Russell F. Doolittle, Searching for differences between fibrinogen and fibrin that affect the initiation of fibrinolysis, Cardiovasc. Hematol. Agents Med. Chem, 6, 181-189 (2008). Russell F. Doolittle, Yong Jiang and Justin Nand, Genomic Evidence for a Simpler Clotting Scheme in Jawless Vertebrates, J. Mol. Evol, 66, 185-196 (2008). DORRESTEIN, PIETER C. B.S, 1998, Northern Arizona University; Ph.D, 2004, Cornell University. NIH NRSA Fellow, 2004-2006, University of Illinois. Chemical Biology; Mass Spectrometry. TEL: (858) 534-6607 Web: chem-faculty.ucsd.edu/dorrestein/ Email: pdorrestein@ucsd.edu John E. Burke, Yuan-Hao Hsu, Raymond A. Deems, on and Panayiotis O. Vacratsis, Identification of otubain 1 as Jun Yin, Paul D. Straight, Sinisa Hrvatin, Pieter C. Dorre- Sheng Li, Virgil L. Woods, Jr. and Edward A. Dennis, A a novel substrate for the Yersinia protein kinase using chemi- stein, Stefanie B. Bumpus, Cindy Jao, Neil L. Kelleher, Ro- Phospholipid Substrate Molecule Residing in the Membrane cal genetics and mass spectrometry. [Erratum to document berto Kolter and Christopher T. Walsh, Genome-wide high- Surface Mediates Opening of the Lid Region in Group IVA cited in CA144:145397], FEBS Lett, 582, 3159 (2008). throughput mining of natural-product biosynthetic gene clus- Cytosolic Phospholipase A2, J. Biol. Chem, 283, 31227- Matthew J. Rardin, Sandra E. Wiley, Anne N. Murphy, ters by phage display, Chem. Biol. (Cambridge, MA, U. S.), 31236 (2008). David J. Pagliarini and Jack E. Dixon, Dual Specificity Phos- 14, 303-312 (2007). Yuan-Hao Hsu, John E. Burke, Daren L. Stephens, Ray- phatases 18 and 21 Target to Opposing Sides of the Mito- Christopher T. Calderone, David F. Iwig, Pieter C. Dorremond A. Deems, Sheng Li, Kyle M. Asmus, Virgil L. chondrial Inner Membrane, J. Biol. 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