UNIVERSITY OF CALIFORNIA, SAN DIEGO
UNIVERSITY OF CALIFORNIA, SAN DIEGO
UNIVERSITY OF CALIFORNIA, SAN DIEGO
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<strong>CALIFORNIA</strong>, <strong>SAN</strong> <strong>DIEGO</strong> 15<br />
Nicholas J. Schork, Congenital disease SNPs target lineage Email: mht@chem.ucsd.edu<br />
of a transcriptional terminator, Nucleic Acids Research, 34,<br />
specific structural elements in protein kinases, Proc. Natl. mthiemens@ucsd.edu<br />
6461-6471 (2006).<br />
Acad. Sci. U. S. A, 105, 9011-9016 (2008). S. A. Aireau, J. Farquhar, M. H. Thiemens, L. A. Leshin, K. S. Keating, N. Toor and A. M. Pyle, The GANC tetra-<br />
Natarajan Kannan, Nina Haste, Susan S. Taylor and An- H. Bao and E. Young, Planetesimal sulfate and aqueous al- loop receptor interaction, Journal of Molecular Biology, 383,<br />
drew F. Neuwald, The hallmark of AGC kinase functional di- teration in CM and CI carbonaceous chondrites, Geochinica 475-481 (2008).<br />
vergence is its C-terminal tail, a cis-acting regulatory mod- Cosmochimica Acta, 69, 4166-4171 (2005).<br />
N. Toor, K. Rajashankar, K. S. Keating and A. M. Pyle,<br />
ule. [Erratum to document cited in CA146:333062], Proc. R. Jost, G. Michalski and M. H. Thiemens, Comparison of Structural basis of exon recognition by a group II intron, Na-<br />
Natl. Acad. Sci. U. S. A, 105, 9130 (2008). rovibronic density of symmetric versus symmetric NO2 iso- ture Structural and Molecular Biology, 15, 1221-1222<br />
topologues at dissociation threshold: Broken symmetry ef- (2008).<br />
TEZCAN, F. AKIF (b.1972) Assistant Professor. A.B, fects, J. (Chemistry). Physics, 123, 054230 (2005).<br />
N. Toor, K. S. Keating, S. D. Taylor and A. M. Pyle, Crys-<br />
1995, Macalester College; Ph.D, 2001, Caltech. Re- J. R. McCabe, C. S. Boxe, A. J. Colussi, M. R. Hoffmann tal structure of a self-spliced group II intron, Science, 320,<br />
search Fellow, 2001-2005, Caltech. Bioinorganic Chem- and M. H. Thiemens, Oxygen isotopic fractionation in the 77-82 (2008).<br />
istry. Metal-Protein and Protein-Protein Interactions photochemistry of nitrate and ice, J. Geophys. Res, 110, D15-<br />
Metal-Directed Protein Self-Assembly Biological Nitro- D15310 (2005). TOR, YITZHAK (b.1960) Professor. B.Sc, 1982, Telgen<br />
Fixation. TEL: (858) 534-4862 FAX: (858) 534- B. Alexander, R. J. Park, D. J. Jacob, Q. B. Li, R. M. Yan- Aviv University, Israel; Ph.D, 1990, The Weizmann In-<br />
6157<br />
tosca, J. Savarino, C. C. W. Lee and M. H. Thiemens, Sulfate stitute of Science, Israel. Weizmann Postdoctoral Fel-<br />
Web: tezcan.ucsd.edu<br />
formation in sea-salt aerosols: Constraints from oxygen iso- lowship, 1990-1993, California Institute of Technology.<br />
topes, J. Geophys. Res. Atmospheres). J. Geophys. Res, 110,<br />
Email: tezcan@ucsd.edu<br />
Bioorganic Chemistry; Organic Chemistry. RNA–small<br />
D10307 (2005).<br />
Eric N. Salgado, Jasmin Faraone-Mennella and F. Akif V. K. Rai, T. L. Jackson and M. H. Thiemens, Photochem-<br />
molecule interactions; antiviral and antibacterial agents;<br />
Tezcan, Controlling Protein-Protein Interactions through ical mass independent sulfur isotopes in achondritic meteornew emissive nucleosides and oligonucleotides; novel<br />
Metal Coordination: Assembly of a 16-Helix Bundle Protein, ites, Science, 309, 1062-1065 (2005).<br />
cellular delivery agents. TEL: (858) 534-6401 FAX:<br />
J. Am. Chem. Soc, 129, 13374-13375 (2007). Mark H. Thiemens, History and applications of mass inde- (858) 534-0202<br />
Eric N. Salgado, Richard A. Lewis, Jasmin Faraone-Men- pendent isotope effects, Annual Reviews of Earth and Plane- Web: www-chem.ucsd.edu/research/profile.cfm?cid=<br />
nella and F. Akif Tezcan, Metal-Mediated Self-Assembly of tary Sciences, 34, 217-262 (2006).<br />
C02218<br />
Protein Superstructures: Influence of Secondary Interactions T. A. Mather, J. R. McCabe, V. K. Rai, M. K. Thiemens, Email: ytor@ucsd.edu<br />
on Protein Oligomerization and Aggregation, J. Am. Chem. D. M. Pyle, T. H. E. Heaton, H. J. Sloane and G. Fern, Oxy-<br />
Soc, 130, 6082-6084 (2008).<br />
Lev Elson-Schwab and Yitzhak Tor, Targeting HIV-1<br />
gen and sulfur isotopic composition of volcanic sulfate aero- RNA with aminoglycoside antibiotics and their derivatives,<br />
sol at the point of emission, J. Geophys. Res, 111, D18205<br />
Aminoglycoside Antibiot, 267-287, 2 plates (2007).<br />
THEODORAKIS, EMMANUEL A. (b.1964) Pro- (2006).<br />
Christopher M. Barbieri, Malvika Kaul, Melanie Bozzafessor.<br />
B.S, 1987, University of Athens, Greece; M.S, J. Savarino, J. Kaiser, S. Morin, D. M. Sigman and M. H.<br />
Hingos, Fang Zhao, Yitzhak Tor, Thomas Hermann and Dan-<br />
1989, University of Paris XI, France; Ph.D, 1993, Uni- Thiemens, Nitrogen and oxygen isotopic constraints on the<br />
iel S. Pilch, Defining the molecular forces that determine the<br />
versity of Paris XI, France. Postdoctoral, 1993-1995, origin of atmospheric nitrate in coastal Antarctica, Atmos.<br />
impact of neomycin on bacterial protein synthesis: impor-<br />
Scripps Research Institute. Bioorganic Chemistry; Or- Chem. Phys, 7, 1925-1945 (2007).<br />
tance of the 2’-amino functionality, Antimicrob. Agents Cheganic<br />
Chemistry. Synthesis of natural products; develop- M. De Angelis, M. H. Thiemens, J. Savarino and J. R. Pet-<br />
mother, 51, 1760-1769 (2007).<br />
it, Contributions of an ancient evaporitic-type reservoir to<br />
ment of synthetic methodology; and interaction of organ- Seergazhi G. Srivatsan and Yitzhak Tor, Fluorescent Py-<br />
Lake Vostok chemistry, Earth and Planetary Science Letters,<br />
ic molecules with biomolecules. TEL: (858) 822-0456<br />
rimidine Ribonucleotide: Synthesis, Enzymatic Incorpora-<br />
222, 751-765 (2007).<br />
FAX: (858) 822-0386 Tetsuya Yokoyama, Vinai K. Rai, Conel M. O’D. Alexantion,<br />
and Utilization, J. Am. Chem. Soc, 129, 2044-2053<br />
Web: www.chem-faculty.ucsd.edu/Theodorakis/index. der, Roy S. Lewis, Richard W. Carlson, Steven B. Shirey,<br />
(2007).<br />
html Mark H. Thiemens and Richard J. Walker, Osmium isotope<br />
Victor K. Tam, Denise Kwong and Yitzhak Tor, Fluores-<br />
Email: etheodor@ucsd.edu evidence for uniform distribution of s- and r-process compo-<br />
cent HIV-1 Dimerization Initiation Site: Design, Properties,<br />
nents in the early Solar system, Earth Planet. Sci. Lett, 259,<br />
and Use for Ligand Discovery, J. Am. Chem. Soc, 129, 3257-<br />
Gianni Guizzunti, Thomas P. Brady, Vivek Malhotra and<br />
567-580 (2007).<br />
3266 (2007).<br />
Emmanuel A. Theodorakis, Trifunctional norrisolide probes<br />
Vinai K. Rai and Mark H. Thiemens, Mass independently<br />
Edith C. Glazer, Douglas Magde and Yitzhak Tor, Ruthefor<br />
the study of Golgi vesiculation, Bioorg. Med. Chem. Lett,<br />
fractionated sulfur components in chondrites, Geochim. Cosnium<br />
Complexes That Break the Rules: Structural Features<br />
17, 320-325 (2007).<br />
mochim. Acta, 71, 1341-1354 (2007).<br />
Controlling Dual Emission, J. Am. Chem. Soc, 129, 8544-<br />
Derek Fischer and Emmanuel A. Theodorakis, Studies on<br />
M. A. Tyra, J. Farquhar, B. A. Wing, G. K. Benedix, A. J.<br />
8551 (2007).<br />
the synthesis of Schisandraceae natural products: exploring a<br />
T. Jull, T. Jackson and M. H. Thiemens, Terrestrial alteration<br />
Lev Elson-Schwab, Omai B. Garner, Manuela Schuksz,<br />
cyclopropylcarbinol ring expansion strategy, Eur. J. Org.<br />
of Antarctic CM chondrite meteorites in a suite of Antarctic<br />
Brett E. Crawford, Jeffrey D. Esko and Yitzhak Tor, Guani-<br />
Chem, 4193-4196 (2007).<br />
CM chondrites: Evidence from oxygen and carbon isotopes,<br />
dinylated Neomycin Delivers Large, Bioactive Cargo into<br />
Paqui G. Traves, Sonsoles Hortelano, Miriam Zeini, Ta-<br />
Geochimica Cosmochimica Acta, 71, 782-795 (2007).<br />
Cells through a Heparan Sulfate-dependent Pathway, J. Biol.<br />
Hsiang Chao, Thanh Lam, Saskia T. Neuteboom, Emmanuel<br />
S. A. Ewing, G. Michalski, M. Thiemens, R. C. Quinn, J.<br />
Chem, 282, 13585-13591 (2007).<br />
A. Theodorakis, Michael A. Palladino, Antonio Castrillo and<br />
L. Macalady, S. Kohl, S. D. Wankel, C. Kendall, C. P.<br />
Seergazhi G. Srivatsan and Yitzhak Tor, Synthesis and en-<br />
Lisardo Bosca, Selective activation of liver X receptors by<br />
McKay and R. Amundson, Rainfall limit of the N cycle on<br />
zymatic incorporation of a fluorescent pyrimidine ribonuacanthoic<br />
acid-related diterpenes, Mol. Pharmacol, 71, 1545-<br />
Earth, Global Biogeochemical Cycles, 21, GB3009 (2007).<br />
cleotide, Nat. Protoc, 2, 1547-1555 (2007).<br />
1553 (2007).<br />
Justin R. McCabe, Mark H. Thiemens and Joel Savarino, A<br />
Nicholas J. Greco and Yitzhak Tor, Synthesis and site-spe-<br />
Derek Fischer, Emmanuel A. Theodorakis and Mark A.<br />
record of ozone variability in South Pole Antarctic snow: role<br />
cific incorporation of a simple fluorescent pyrimidine, Nat.<br />
Haidekker, Synthesis and use of an in-solution ratiometric<br />
of nitrate oxygen isotopes, J. Geophys. Res., [Atmos.], 112,<br />
Protoc, 2, 305-316 (2007).<br />
fluorescent viscosity sensor, Nat. Protoc, 2, 227-236 (2007).<br />
D12303/1-D12303/9 (2007).<br />
Renatus W. Sinkeldam and Yitzhak Tor, To D or not to D?<br />
Mark A. Haidekker and Emmanuel A. Theodorakis, Mo-<br />
N. Patris, S. S. Cliff, P. K. Quinn, M. Kasem and M. H.<br />
On estimating the microenvironment polarity of biomoleculecular<br />
rotors-fluorescent biosensors for viscosity and flow,<br />
Thiemens, Isotopic analysis of aerosol sulfate and nitrate durlar<br />
cavities, Org. Biomol. Chem, 5, 2523-2528 (2007).<br />
Org. Biomol. Chem, 5, 1669-1678 (2007).<br />
ing ICT-2k2: Determination of different formation pathways<br />
Nicholas J. Greco and Yitzhak Tor, Furan decorated nucle-<br />
Ayse Batova, Thanh Lam, Veit Wascholowski, Alice L.<br />
as a function of particle size, J. Geophysical Research, 112,<br />
oside analogues as fluorescent probes: synthesis, photophysi-<br />
Yu, Athanassios Giannis and Emmanuel A. Theodorakis,<br />
D23301 (2007).<br />
cal evaluation, and site-specific incorporation, Tetrahedron,<br />
Synthesis and evaluation of caged Garcinia xanthones, Org.<br />
Yuki Kimura, Joseph A. Nuth, III, Subrata Chakraborty<br />
63, 3515-3527 (2007).<br />
Biomol. Chem, 5, 494-500 (2007).<br />
and Mark H. Thiemens, Non-mass-dependent oxygen isoto-<br />
Seergazhi G. Srivatsan and Yitzhak Tor, Using an emissive<br />
Matthew E. Nipper, Sheereen Majd, Michael Mayer, James<br />
pic fractionation in smokes produced in an electrical disuridine<br />
analogue for assembling fluorescent HIV-1 TAR con-<br />
C.-M. Lee, Emmanuel A. Theodorakis and Mark A. Hai-<br />
charge, Meteorit. Planet. Sci, 42, 1429-1439 (2007).<br />
structs, Tetrahedron, 63, 3601-3607 (2007).<br />
dekker, Characterization of changes in the viscosity of lipid<br />
Melanie Baroni, Mark H. Thiemens, Robert J. Delmas and<br />
Yitzhak Tor, Susan Del Valle, David Jaramillo, Seergazhi<br />
membranes with the molecular rotor FCVJ, Biochim. Bio-<br />
Joel Savarino, Mass-independent sulfur isotopic composi-<br />
G. Srivatsan, Andro Rios and Haim Weizman, Designing<br />
phys. Acta, Biomembr, 1778, 1148-1153 (2008).<br />
tions in stratospheric volcanic eruptions, Science (Washingnew<br />
isomorphic fluorescent nucleobase analogues: the thieno<br />
Alba Diaz-Rodriguez, Susana Fernandez, Yogesh S.<br />
ton, DC, U. S.), 315, 84-87 (2007).<br />
[3,2-d]pyrimidine core, Tetrahedron, 63, 3608-3614 (2007).<br />
Sanghvi, Emmanuel A. Theodorakis, Vicente Gotor and Mi-<br />
Gerardo Dominguez, Terri Jackson, Burton Brothers,<br />
Seergazhi Srivatsan, Nicholas J. Greco and Yitzhak Tor, A<br />
guel Ferrero, Synthesis of 2’,3’-cyclohexene bicyclic nucleo-<br />
Bryan Nguyen and Mark H. Thiemens, Discovery and meahighly<br />
emissive fluorescent nucleoside that signals the activiside<br />
analogues as antiviral compounds, Nucleic Acids Symp.<br />
surement of an isotopically distinct source of sulfate in<br />
ty of toxic ribosome-inactivation proteins, Angew. Chem.,<br />
Ser, 52, 99-100 (2008).<br />
Earth’s atmosphere, Proc. Natl. Acad. Sci. U. S. A, 105,<br />
Int. Ed, 47, 6661-6665 (2008).<br />
12769-12773 (2008).<br />
Renatus W. Sinkeldam, Nicholas J. Greco and Yitzhak<br />
Derek A. Fischer, Synthetic studies toward complex natu-<br />
Subrata Chakraborty, Musahid Ahmed, Teresa L. Jackson<br />
Tor, Polarity of major grooves explored by using isosteric<br />
ral products. (D)<br />
and Mark H. Thiemens, Experimental Test of Self-Shielding<br />
emissive nucleoside, ChemBioChem, 9, 706-709 (2008).<br />
Fatima R. Rivas, Synthetic studies towards the total synin<br />
Vacuum Ultraviolet Photodissociation of CO, Science<br />
Seergazhi G. Srivatsan, Haim Weizman and Yitzhak Tor,<br />
thesis of norzoanthamine. (D)<br />
(Washington, DC, U. S.), 321, 1328-1331 (2008).<br />
A highly fluorescent nucleoside analog based on thieno[3,4-<br />
Thanh T. Lam, synthetic studies towards diterpenes; synd]pyrimidine<br />
senses mismatched pairing, Org. Biomol.<br />
thetic studies towards the caged garcinia xanthones. (D)<br />
Chem, 6, 1334-1338 (2008).<br />
Thomas Patrick Brady, Total synthesis of norrisolide, syn- TOOR, NAVTEJ SINGH (b.1973) Assistant Profes-<br />
Manuela Schuksz, Mark M. Fuster, Jillian R. Brown, Brett<br />
thesis of norrisolide analogues, and biological evaluation of sor. B.Sc, 1996, University of Calgary; Ph.D, 2004, Uni- E. Crawford, David P. Ditto, Roger Lawrence, Charles A.<br />
norrisolide probes. (D) versity of Calgary. Howard Hughes Medical Institute Glass, Lianxhun Wang, Yitzhak Tor and Jeffrey D. Esko,<br />
Postdoctoral Fellow, 2004-2009, Yale University. Bio- Surfen, a small molecule antagonist of heparan sulfate, Proc.<br />
THIEMENS, MARK H. (b.1950) Professor and chemistry; Structural Biology. Group II introns are self- Natl. Acad. Sci. U. S. A, 105, 13075-13080 (2008).<br />
Dean. B.S, 1972, University of Miami; M.S, 1974, Old splicing RNAs which are thought to be the ancestors of<br />
Dominion University; Ph.D, 1977, Florida State Univer- both retrotransposons and spliceosomal introns, which Nicholas J. Greco, Design, synthesis and application of<br />
sity. Postdoctoral Fellowship, 1977-1980, University of together make up more than 50% of the human genome. novel fluorescent nucleosides. (D)<br />
Chicago. Atmospheric Chemistry; Physical Chemistry. My research interests include studying the structure and Victor K. Tam, Targeting unique nucleic acid structures<br />
Measurement of isotope ratios in atmospheric species; function of group II introns, as well as the spliceosome, with small molecules. (D)<br />
application of high precision stable isotope ratio mea- using a combination of x-ray crystallography and<br />
surement to resolve quantum chemical astrophysical and biochemistry. TEL: (858) 534-3211 FAX: (858) 534- TROGLER, WILLIAM C. Professor. B.A, 1974,<br />
atmospheric processes; studies on the evolution of the 6255<br />
Johns Hopkins; M.A, 1974, Johns Hopkins; Ph.D, 1977,<br />
solar system and nucleosynthesis. Paleoclimatology and Email: ntoor@ucsd.edu<br />
California Institute of Technology. Materials Chemistry;<br />
ice core studies. Investigations of the origin and evolu- N. Toor, A. R. Robart, J. Christianson and S. Zimmerly, Nanochemistry. Inorganic polymers and nanoparticles as<br />
tion of planets and life. TEL: (858) 534-6882 FAX: Self-splicing of a group IIC intron: 5’ exon recognition and luminescent and electronic sensors for explosives. Char-<br />
(858) 822-0389 alternative 5’ splicing events implicate the stem-loop motif acterization of the chemoselectivity of field effect tran-