Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Arthroplasty - Hip
Abstract number: 25782
TRANEXAMIC ACID IN TOTAL HIP REPLACEMENTS: A META-ANALYSIS
Sukeik MOHAMED 1 , Sattar ALSHRYDA 2 , Fares S HADDAD 1 , James MASON 3
1 University College London Hospital, London (UNITED KINGDOM), 2 The James
Cook University Hospital, Middlesbrough (UNITED KINGDOM), 3 Wolfson Research
Institute, Stockton-On-Tees (UNITED KINGDOM)
Background: Total hip replacement (THR) is one of the commonest operations in
orthopaedic practice. Although safer than ever, allogeneic transfusion is still
associated with risks for the recipient. Tranexamic acid (TXA) has been popularised
as an effective way to reduce blood loss and subsequent blood transfusion.
Objectives: To investigate the value of TXA in reducing blood loss and blood
transfusion after THR and other clinical outcomes such as deep venous thrombosis
(DVT), pulmonary embolism (PE), ischaemic heart diseases and mortality. Patients
and Methods: A systematic review and meta-analysis of published randomised and
quasi-randomised trials which used TXA to reduce blood loss and transfusion in THR
were conducted.Results: Blood loss: Seven studies (350 patients) were eligible for
this outcome. Using TXA reduced intraoperative blood loss by an average of 104 ml
(P-value 0.0006, 95% CI-164,-44, Heterogeneity I2 0%), postoperative blood loss by
an average of 167 ml (P-value