Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Tumours
Abstract number: 26072
RESPONSE OF GIANT CELL TUMOR OF BONE TO CALCITONIN TREATMENT
A REPORT OF TWO CASES
Anis BEN LASSOUED, Mhamed BAHRI, Wajdi BOUALLÉUE, Ramzi BOUFARÉ
Hopital Ibn Jazzar Kairouan, Kairouan (TUNISIA)
Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor that usually
involves the end of long bones. Our study was dealing with a 54 years old woman
and 16 years old boy having respectively a GCT of right distal radius and left great
trochantera. The tumoral margins were well definited in x rays. CT scan showed
some interrupted cortical sites without soft tissue extension.After confirmed diagnosis
the 2 tumors were curetted and injection of calcitonin was done in the residual
cavities. The calcitonin injection were done postoperatively daily by a percutaneous
approach for a mean period of 15 days.X rays control showed gradually
circumferential bone condensation until complete filling of the tumoral cavity. At
respectively 3 and 1 year follow up, our cases were out of disease with a good
function.The first main purpose of curettage is complete removal of tumoral tissue, it
must be aggressive reaching all tumoral walls. This procedure is difficult in some
deep locations. Therefore, adjuvant therapy by calcitonin is considered as an
additional treatment in case of curettage insufficiency. The abundance of
multinucleated osteoclast-like giant cells is a histological hallmark of the GCT. The
anti-osteoclastic effects of calcitonin on GCT have been well investigated. The drug
has been demonstrated to have receptors on the osteoclast-like giant cells.This may
reduce the rate of local recurrence following surgery in patients with GCT of bone.
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