Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Tumours
Abstract number: 25842
THE IMPACT OF PATHOLOGICAL FRACTURES ON THERAPY OUTCOME IN
PATIENTS WITH PRIMARY MALIGNANT BONE TUMOURS
Babak MORADI 1 , Anita ZAHLTEN-HINGURANAGE 2 , Burkhard LEHNER 1 , Felix
ZEIFANG 3
1 Orthopaedic Clinic, University of Heidelberg, Heidelberg (GERMANY), 2 National
Center for Tumour Diseases (NCT), Heidelberg (GERMANY), 3 Orthopaedic Clinic,
University of Heidelberg, Heidelberg (GERMANY)
In this study we investigated the implications of pathological fractures on therapy
outcome in patients with primary malignant bone tumours and determined whether
limb salvage can be safely performed. A retrospective analysis of 447 patients with
malignant bone tumours was performed. Multivariate Cox regression analysis was
used to investigate the influence of pathological fractures and further independent
variables on survival rate. In 52 of 447 patients, the primary malignant bone tumour
was complicated by a pathological fracture. These fractures were more common in
malignant fibrous histiocytoma of the bone and in the tumour stages IIa/b and III.
Ablative surgery was performed in ten patients and limb salvage surgery in 42
patients. The mortality risk for patients with pathological fractures was significantly
increased by a factor of 1.82 (p=0.015), and overall duration of survival was
significantly lower in the fracture group, with a median of 6.2 years (p