Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_
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Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_ Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

sicot.org
30.01.2013 Views

Poster Topic: Tumours Abstract number: 24903 THE INFLUENCE OF HEAT ON EXTRAVASATION OF IRON-OXIDE NANOPARTICLES IN A TUMOR MODEL Claus TVEDESOE 1 , Steffen HOKLAND 2 , Soeren BACH 1 , Thomas NIELSEN 3 , Esben LARSEN 4 , Michael PEDERSEN 2 , Cody BüNGER 1 1 Orthopaedic Research Laboratory, Aarhus c (DENMARK), 2 MR Research Centre Skejby, Aarhus N (DENMARK), 3 Department of Experimental Oncology, University hospital of Aarhus, Aarhus c (DENMARK), 4 Dept. of Interdisciplinary NANO Research, Aarhus c (DENMARK) Intro: Iron-oxide nanoparticles (USPIO) have proven to be biocompatible and without significant cytotoxicity in humans and they could possibly become useful in future cancer therapy if coupled with anti-cancer agents.Mild hyperthermia can disrupt tumor vessel endothelial barrier, increasing vascular permeability, allowing USPIO particles to diffuse into the interstitial space of tumor. In this study we have investigated the effect of various lengths of localized mild hyperthermia (41,5° C) on the extravasation of i.v injected USPIO particles in a murine tumor model to determine the optimal heating length.M&M:Animals were randomized into groups: 1, USPIO particles only; 2, USPIO particles and 5 min hyperthermia; 3, USPIO particles and 30 min hyper-thermia and 4, USPIO particles and 60 min of hyperthermia. N=9 in each group. Animals were MR scanned prior to injections and after 90-, 390- and 1140 min.Results: Change in T2* in response to heating length shows a significant difference between animals heated for 30- and 60 minutes compared to animals heated for 5 minutes and controls (USPIO particles and no heat) (p

Poster Topic: Tumours Abstract number: 25073 A PSEUDO-ANEURISM IN A PATIENT WITH A SOLITARY OSTEOCHONDROMA OF THE DISTAL FEMUR. A CASE REPORT. Efrain FARIAS CISNEROS, Carlos SUAREZ AHEDO, Felix GIL ORBEZO Hospital Español De Mexico, Mexico City (MEXICO) Osteochondroma is the most common benign bone tumor, and is often diagnosed as an incidental finding. Mostly asymptomatic, they can cause mechanical symptoms depending on their location and size. To our knowledge, not a single case of a pseudo-aneurism of the femoral artery related with an osteochondroma has been reported in the literature so far, although are previous reports of hematoma formation near the bone lesion. This article presents a rare case of a large pseudoaneurism in a patient with a solitary ostechondroma of the distal femur.Case report: 40-year-old man presented with a 9-month history of pain and a progressive growing mass in the posteromedial region of distal left tight. No history of trauma. Physical examination showed a tender, not fixed, painless mass palpable in the posteromedial region of the distal left tight. Radiographs and MRI showed a bony exostosis localized on the posteromedial aspect of the distal third of femoral shaft, irritation in adjacent soft tissues, with various masses -probably hematomas-; the largest producing mass effect and inflammatory changes in muscular tissue. The patient underwent surgery with diagnosis of osteochondroma plus hematomas in the tight. A well-margined, friable tumor was localized contained in the surrounding tissues, during the procedure the wall broke starting bleeding profusely. The arterial wall lesion was repaired. A sessile exostosis was indentified, excised and sent to pathology, along with the remaining mass. Five days later a second procedure was performed to place an endoprosthesis in the left femoral superficial artery in a stenotic zone. 635

Poster<br />

Topic: Tumours<br />

Abstract number: 24903<br />

THE INFLUENCE OF HEAT ON EXTRAVASATION OF IRON-OXIDE<br />

NANOPARTICLES IN A TUMOR MODEL<br />

Claus TVEDESOE 1 , Steffen HOKLAND 2 , Soeren BACH 1 , Thomas NIELSEN 3 , Esben<br />

LARSEN 4 , Michael PEDERSEN 2 , Cody BüNGER 1<br />

1 Orthopaedic Research Laboratory, Aarhus c (DENMARK), 2 MR Research Centre<br />

Skejby, Aarhus N (DENMARK), 3 Department of Experimental Oncology, University<br />

hospital of Aarhus, Aarhus c (DENMARK), 4 Dept. of Interdisciplinary NANO<br />

Research, Aarhus c (DENMARK)<br />

Intro: Iron-oxide nanoparticles (USPIO) have proven to be biocompatible and without<br />

significant cytotoxicity in humans and they could possibly become useful in future<br />

cancer therapy if coupled with anti-cancer agents.Mild hyperthermia can disrupt<br />

tumor vessel endothelial barrier, increasing vascular permeability, allowing USPIO<br />

particles to diffuse into the interstitial space of tumor. In this study we have<br />

investigated the effect of various lengths of localized mild hyperthermia (41,5° C) on<br />

the extravasation of i.v injected USPIO particles in a murine tumor model to<br />

determine the optimal heating length.M&M:Animals were randomized into groups: 1,<br />

USPIO particles only; 2, USPIO particles and 5 min hyperthermia; 3, USPIO particles<br />

and 30 min hyper-thermia and 4, USPIO particles and 60 min of hyperthermia. N=9 in<br />

each group. Animals were MR scanned prior to injections and after 90-, 390- and<br />

1140 min.Results: Change in T2* in response to heating length shows a significant<br />

difference between animals heated for 30- and 60 minutes compared to animals<br />

heated for 5 minutes and controls (USPIO particles and no heat) (p

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