Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Tumours
Abstract number: 24890
ORTHOPAEDIC INTERVENTION AND OUTCOME IN PATIENTS WITH
METASTATIC BONE DISEASES
Masanari AONO, Mikinori IKEDA, Takaaki KURODA, Takashi MAENO, Yuko DATE,
Minori KATO, Akira MATSUMURA, Sadahiko KONISHI, Kenichi KAZUKI
Department of Orthopaedic Surgery, Osaka City General Hospital, Osaka (JAPAN)
[Background] Although new chemotherapeutic agents have improved the survival of
cancer patients, the incidence of metastatic bone diseases (MBDs) has increased.
Several treatment modalities are indicated in patients with MBD. We retrospectively
evaluated the efficacy of our treatment and prognosis in patients with MBD.[Methods]
Between 2006 and 2009, 68 patients with MBD42 men and 26 women (average age,
63 years; range, 31 79 years) visited our institute. The primary cancer sites included
the lungs (20), gastrointestinal tract (8), colorectal region (7), liver (7), prostate (7),
breast (5), kidney (2), and other organs (6); the primary site was unknown in 6
patients. The locations of MBDs included the spine (27), femur (16), pelvis (11),
humerus (8), and other parts (6). Fourteen patients were diagnosed with multiple
bone metastases. [Results] During the mean follow-up period of 14 months (range,
1?38 months), 38 patients died of disease and 17 were alive with disease; 13
patients were lost during follow-up. The 1- and 3-year survival rates were 34% and
15%, respectively. Pathological fractures and paralyses were observed in 18 and 6
patients, respectively. Twenty-four patients underwent surgical treatment, and 8
underwent conservative treatment with radiotherapy. Zoledronate was administrated
in 23 patients.[Conclusions] The longer the patient survives with cancer, the more
complicated the treatment of MBD becomes. Surgical intervention is required for
pathological fractures and paralyses. The treatment aimed at achieving local control,
functional restoration of the affected parts, and improvement in the quality of life.
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