Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Sports Medicine - Knee
Abstract number: 26224
TENDINOPATHY – WHERE DOES THE PAIN COME FROM?
Paul ACKERMANN 1 , Nicos SCHIZAS 1 , Lian OYSTEIN 2 , Frede FRIHAGEN 2 , Lars
ENGEBRETSEN 2 , Roald BAHR 2
1 Karolinska Institutet, Stockholm (SWEDEN), 2 Oslo Sports Trauma Research Center,
Oslo (NORWAY)
Tendinopathy, including pain and tissue proliferation, is suggested to be modulated
via nerve factors. Thus, substance P (SP) and glutamate are known to activate
glutamate receptors in a variety of pain conditions. The aim of this study was to
assess the presence, tissue density and co-existence of different glutamate receptors
together with glutamate and SP in biopsies of tendinopathy patients and
controls.Human patellar tendinopathic (n=10) and control (n=8) biopsies were single-
and double-stained immunohistochemically for glutamate, glutamate receptors
(NMDAR1, Phospho-NMDAR1 (activated receptor), mGluR1, mGluR5 and
mGluR6,7), the nerve marker PGP9.5 and SP and assessed subjectively and semiquantitatively
with image analysis. Non-parametric Mann-Whitney U-tests for
independent samples were used. Significance, p