Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Spine
Abstract number: 26305
INTRATHECAL MORPHINE ANALGESIA IN IDIOPATHIC SCOLIOSIS SURGERY:
DOES GENDER OR RACIAL GROUP AFFECT OPTIMAL DOSING?
George THOMPSON, Jochen SON-HING, Connie POE-KOCHERT, Paul TRIPI,
Jennifer POTZMAN
Rainbow Babies and Children's Hospital, Cleveland (UNITED STATES)
Purpose: To ensure our protocol of intrathecal morphine (9-19 µg/kg) for analgesia in
idiopathic scoliosis surgery was effective across gender and race. Methods: We
studied 287 patients given optimal dose of intrathecal morphine. There were 246
female and 47 male patients; 224 Caucasian (CA) and 63 African-American (AA)
patients. Factors analyzed postoperative Visual analog pain (1-10) scores (VAS),
time to first opioid rescue dose, total morphine over the first 48 hours, and
postoperative complications. Results: In females and males, the mean VAS pain
scores post-anesthesia care unit (PACU) were 0.48 and 0.56, mean times to first
opioid rescue dose was 16.65 and 16.72 hours, and total morphine over first 48
hours was 1.49 mg/kg. Respiratory depression and PICU admission occurred in 10
(4.1%) and 3 (6.4%) patients. Nausea and vomiting occurred in 78 (31.7%) and 12
(25.5%) patients. For CA and AA patients, mean VAS pain scores in PACU was 0.48
and 0.46, mean times to first opioid rescue dose was 16.53 and 17.2 hours, and total
morphine over the first 48 hours were 1.54 mg/kg and 1.30 mg/kg. Respiratory
depression and PICU admission occurred in 9 (4.0%) and 4 (6.3%) patients. Nausea
and vomiting occurred in 77 (34.4%) and 11 (17.5%) patients. Conclusions: Our
optimal intrathecal morphine dose provides effective and safe postoperative
analgesia in patients undergoing surgery irregardless of gender or race.
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