Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Osteoporosis
Abstract number: 25787
EFFECTIVENESS OF INTERMITTENT PAMIDRONATE FOR TREATMENT ON
SEVERE OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
Vladyslav POVOROZNYUK, Volodymyr VAYDA, Tetyana ORLYK, Maryna
BYSTRYTSKA, Nataliia DZEROVYCH
Institute of Gerontology AMS Ukraine, Kyiv (UKRAINE)
Objective: to evaluate the effect of intravenous pamidronate treatment in
postmenopausal women with severe osteoporosis. Object: There were examined 20
women with osteoporotic vertebral fractures, aged 56-78 years (67.8±1.41). During
the complex treatment patients were got pamidronate (generic drug “Pamired”) 30-90
mg once in 3 month and 2 tablets of Calcemin-advance a day during 12 months. The
patients of group A were got 140 ± 10 mg pamidronate, group B - 295 ± 16 mg
pamidronate.Methods: Dual-energy X-ray absorptiometry was held before and after
3, 6, 9 and 12 months pamidronate treatment. The examination of pain syndrome
was performed by VAS scale. Results: After 3 months of treatment a significant
decrease of pain syndrome was observed, and during 6, 9 and 12 months intensity of
pain significantly decreased in group A, B and in the whole group. Three months later
lumbar spine BMD was increased and continue to increase 12 month after in two
groups, but the significant elevation was in group B. Conclusions: It was shown, that
pamidronate treatment significantly influences the BMD lumbar spine during 12
months treatment in two groups and keep increased BMD femoral neck in 9 months
in group B and decreases the intensity of the pain syndrome just after 3 months
therapy and has it’s effect during the whole therapy course.
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