Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Osteoporosis
Abstract number: 25521
INCREASED FRACTURE RISK IN PATIENTS WITH RHEUMATIC DISORDERS
AND OTHER INFLAMMATORY DISEASES. A CASE-CONTROL STUDY WITH
53,108 FRACTURE PATIENTS.
Rüdiger WEISS 1 , Paul ACKERMANN 1 , Scott MONTGOMERY 2
1 Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sports
Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm
(SWEDEN), 2 Department of Medicine, Clinical Epidemiology Unit, Karolinska
University Hospital, Karolinska Institutet, Stockholm (SWEDEN)
Background: Chronic inflammatory diseases, such as rheumatic disorders (RD) and
inflammatory bowel diseases (IBD), have cost implications for health care provision,
employers and insurers. Some of this expense is due to co-morbidity including bone
fractures. The aim of this study was to identify the risk of hip and vertebral fractures
in patients with RD and IBD. Methods: This population-based case control study,
assessed the fracture risk of patients with rheumatoid arthritis (RA), juvenile
idiopathic arthritis (JIA), ankylosing spondylitis (AS), systemic lupus erythematosus
(SLE), polymyositis/dermatomyositis (PM/DM), systemic sclerosis (SSc), Crohn’s
disease (CD) and ulcerative colitis (UC). The study cohort comprised 53,108 fracture
patients (66% females) and 370,602 age- and sex-matched controls. Results: There
was a statistically significant increased fracture risk for all RD and for IBD when
compared with controls. The magnitude of fracture risk was higher for patients with
RD (OR 3.0, 95% CI 2.9-3.2) than for IBD (OR 1.6, 1.4-1.8). The ORs in RD ranged
from 2.6 (1.3-4.9) for SSc to 4.0 (3.4-4.6) for AS. The largest increased fracture risk
for vertebral fractures was seen in AS (OR 7.1, 6.0-8.4) and for hip fractures in JIA
(OR 4.1, 2.4-6.9). Conclusion: Our results highlight the existence of an increased
fracture risk in patients with RD and IBD due to a variety of underlying causes. In
many inflammatory diseases, implementation of fracture prevention strategies may
be beneficial.
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