Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Infections
Abstract number: 24467
EVALUATION OF SENSITIVITY AND SPECIFICITY OF 99M-TECHNETIUM
ISONIAZID SCAN FOR DIAGNOSIS OF SKELETAL TUBERCULOSIS.
Sakthivel Rajan RAJARAM MANOHARAN 1 , Raj NIRMAL 2 , Vijay GONI 1 , Baljinder
SINGH 1 , Vibhu Krishnan VISWANATHAN 1 , Sujit Kumar TRIPATHY 1
1 Post Graduate Institute of Medical Education and Research, Chandigarh (INDIA),
2 Chennai Medical College Hospital and Research Centre, Trichy (INDIA)
The aim of our study was to evaluate the sensitivity and specificity of 99m-
Technetium Isoniazid scan for the diagnosis of skeletal tuberculosis. 20 patients with
strong clinical, radiological and microbiological evidence were included in the study
presenting in the time period of January 2007 to February 2009. Patients already on
antitubercular treatment, pregnant females, those with hepatic and renal
abnormalities, and those with hypersensitivity to Isoniazid are excluded from the
study. All patients were initially subjected to 99m-Tc Bone Scan and those patients
with positive result were then subjected to INH Scan and images were acquired at
1hr, 4 hr and 24 hr. After the images are acquired, the samples were taken and sent
for mycobacterial culture (taken as the gold standard). Of the culture positive cases,
69.2 % of cases were positive and 30.8% of cases were negative for 99m-Tc- INH
Scan. Sensitivity, Specificity, Positive Predictive value, Negative predictive value and
diagnostic accuracy were found to be 69.2%, 71.4%, 81.8%, 55.5%, and 70%
respectively. Hence we conclude that 99mTc-INH Scan has a good sensitivity and
specificity for the diagnosis of skeletal tuberculosis. Furthermore it is noninvasive,
nontraumatic and it can be done on outpatient basis to rule out skeletal tuberculosis.
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