Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: General Orthopaedics
Abstract number: 23451
THE ROLE OF REACTIVE OXYGEN SPECIES IN ISCHAEMIC- REPERFUSION
INJURY AND THE USE OF ANTIOXIDANTS IN ITS POTENTIAL PREVENTION
FOLLOWING KNEE SURGERY
Simon GRAHAM
Leeds General Infirmary, Academic Orthopaedic Unit, Leeds (UNITED KINGDOM)
In the UK, over 55, 000 TKAs are carried out annually, most of which have a
successful outcome. The pneumatic tourniquet has long been an indispensable tool
in the practice of orthopaedic surgery and it is used as a mean to provide a clean
bloodless surgical field, aid visualisation of vital structures, minimize blood loss and
hence expedite the procedure. Restoration of adequate blood flow following
tourniquet application is essential to salvage ischaemic skeletal muscle, providing
oxygen and substrates that are necessary for tissue recovery and concurrently
removes toxic metabolites. However, reperfusion may induce various detrimental
processes that may cause further tissue damage. Such deterioration of tissue
function after reperfusion is defined as ischaemia-reperfusion injury. The
consequences of ischemia-reperfusion injury vary from reversible cell dysfunction to
local and remote tissue destruction, multiple organ failure and death. This
poster/presentation aims to provide a review of ischaemia-reperfusion injury (I-R)
following knee arthroplasty and arthroscopy. While I-R injury is thought to be multifactorial
in its aetiology and pathogenesis, this poster/review is designed to focus on
the specific role of free radicals and reactive oxygen species (ROS) as well as the
importance of antioxidants in its attenuation and potential prevention.
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