Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Biomaterials
Abstract number: 26468
THE ADVANTAGES OF MACROPOROUS BIPHASIC CERAMIC BONE
SUBSTITUTES. CLINICAL AND HISTOLOGICAL RESULTS WITH APPLICATION
OF CERAFORM AND EUROCER IN BONE DEFECTS
Paul-Dan SIRBU, Luminita SIMION, Tudor PETREUS, Florin MUNTEANU, Ioan
PETCU, Marius BAR, Paul BOTEZ
GrT Popa University of Medicine and Pharmacy, Iasi (ROMANIA)
Bone defects are a frequent clinical problem in trauma and orthopaedic surgery.
Biomaterials are usually used as scaffolds. The purpose of this study is to investigate
the biocompatibility and osseointegration for two synthetic biphasic ceramic bone
substitutes (Ceraform and Eurocer). The study was performed in a 3 years interval
with a minimal follow-up of 1 year. We have included 42 cases requiring bone
substitution (fractures, bone tumors, spinal fusions, revision artroplasty, non-unions,
osteitis). Preoperative selection and postoperative follow-up were made by GESTO
evaluation protocol (Greffes et Substitutes Tissulaires en Orthopedie). Missing bone
quantification was realized intraoperatively by using GESTO classification of bone
loss TOD (Type-Os-Dimension). We had two study groups, one for each compound,
21 cases with Ceraform and 21 with Eurocer. These two biomaterials were used as
single substitute or mixed with allo or autograft. The radiological survey was
performed at 3, 6, 9 and 11 months. Radiological results were assessed by three
parameters: substitute bone interface, radiological density of the bone substitute, the
possibility of fracture fragmentation. We have observed the radiological integration at
9-12 months after implantation. The bone biopsy during implant removal (minimum
18 months after implantation) showed in all cases a cancellous like bone tissue
formation with osteocytes and vascular buds. Osteoblasts were present at the
margins of the mineralized bone. The radiological and histological results suggest
that with a good contact between the bone substitute and receiver bone, with
construct augmentation by osteosynthesis implants, Ceraform and Eurocer represent
a valuable alternative to bone grafts.
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