Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Biomaterials
Abstract number: 26450
BONE INGROWTH TO NOVEL TITANIUM FOAMS IN RABBIT DISTAL FEMUR
Yuehuei AN 1 , Qian KANG 2 , Rewen ZHANG 3
1 Medical University of South Carolina, Charleston (UNITED STATES), 2 Clemson
University, Charleston (UNITED STATES), 3 Stryker Orthopaedics, Mahwah (UNITED
STATES)
This study compared the osteointegration of a novel titanium foam with five different
pore sizes but same density in a rabbit distal femoral defect model. A new technique,
Particle Sintered Foam (PSF), was used for the fabrication of the test articles which
were machined into cylinders, 8mm×5mm. Twenty NZW rabbits were randomly
divided into five groups. Five different pore size cylinder, range from 388m to 530m,
were implanted into the bilateral distal femur of the rabbits. The animals were
sacrificed 6-week postoperatively. The distal femurs containing implants were
analyzed using µCT. Bone ingrowth was evaluated as the percentage of bone in the
porous space. All of the PSF implants with the specific parameters yielded good
bone ingrowth, from 25% to 38%. MicroCT generated structural indices for PSF
implants, including connectivity density, number of struts, thickness of struts, strut
separation and total surface. Among them the strut separation most likely represents
the size of pores. Within the ranges evaluated, the smaller the pore size (strut
separation) and the greater the number of interconnecting pores (interconnecting
pore density) the greater the bone ingrowth into the porous material. Our data
demonstrate that the bone ingrowth is significant correlated to the 3-D structure of
the titanium implants, the pore size and interconnectivity.
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