Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Biomaterials
Abstract number: 26318
BONE-ANCHORED OSSEOINTEGRATED AMPUTATION PROSTHESES: A
HISTOLOGICAL STUDY OF SIX IMPLANTS RETRIEVED AFTER MORE THAN 10
YEARS
Anders PALMQUIST, Birgitta NORLINDH, Rickard BRÅNEMARK, Peter THOMSEN
Department of Biomaterials, The Sahlgrenska Academy at University of Gothenburg,
Göteborg (SWEDEN)
Amputees have significant problems related to the use of socket prosthesis. The
quality of life could be improved with the use of bone-anchored amputation
prosthesis where the external prosthesis is anchored to the bone through a titanium
implant (screw-shaped fixture). The aim of this human retrieval study was to
histologically evaluate the bone-implant interaction of bone-anchored amputation
prostheses. The prostheses were retrieved with surrounding tissue by using a
trephine. Six titanium implants from five patients were retrieved due to fracture of the
implant in four cases (four implants) and chronic problems with infection for one case
(two implants). The locations of the retrieved implants were one congenital hand
malformation, one transradial amputation and three transfemoral amputations. The
mean time from implantation to retrieval was 138 months, ranging from 131-167
months. Ground-sections of undecalcified bone-implant specimens prepared by
sawing and grinding were evaluated by light microscopy. The results showed mature
bone tissue around and in direct contact with the implant. At the hollow apical end,
ingrowth of predominantly trabecular bone was observed, while cortical bone was
around the outside of the screw-shaped implant. Histomorphometry showed mean
60% (24-85%) bone-implant contact and mean 62% (31-87%) bone area within the
threads. The present results show, for the first time, morphological evidence of longterm,
direct implant-bone contact of human amputation prostheses. The
histomorphometric data is in the agreement with what has been previously reported
for osseointegrated dental implants and bone-anchored hearing aids. Supported by
the Swedish Research Council (grant K2009-52X-09495-22-3) and LUA grant
(ALFGBG-11128).
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