Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Biomaterials
Abstract number: 26260
CYTOTOXICITY AND BIOCOMPATIBILITY OF A NEW IRON-BASED
DEGRADABLE BIOMATERIAL FOR BONE REPLACEMENT
Bernd WEGENER 1 , Anton SICHLER 1 , Birte SIEVERS 1 , Stefan MILZ 2 , Peter
QUADBECK 3 , Wolfram BREUER 4 , Nies BERTHOLD 5 , Volkmar JANSSON 2
1 Ludwig-Maximilians-Universität München, Department of Orthopaedic Surgery,
München (GERMANY), 2 Anatomical Institute, München (GERMANY), 3 Fraunhofer
Institut (IFAM), Dresden (GERMANY), 4 Ludwig-Maximilians-University Munich,
Animal Pathologic Institut, München (GERMANY), 5 InnoTERE GmbH, Dresden
(GERMANY)
Metal materials play a key role in the repair or the replacement of destroyed bones.
Due to their mechanically stability there are able to assume the burden of defect
bones and have a high damage tolerance. The basic idea of the present work is to
design degradable implants with a cellular metal structure for bone replacement. To
investigate the cytotoxicity of different alloys fibroblasts were seeded in a monolayer
culture and also in a special developed perfusions culture system. Implants were
constructed out of the alloy with the best outcome. They were investigated in an in
vivo experiment in sheeps. We investigate the periimplant soft tissue, lymphe node,
brain, liver, spleen and kidney to an inflammatory diseases and sediments from the
implant material. After 6 month only a small part of the implant has been degraded.
No sediments and no inflammation were detected in brain, liver, spleen and kidney.
In the periimplant soft tissue and the lymphe node sediment of the alloy could be
found. But there were no inflammatory disease. The new degradable iron based
implant for bone replacement shows an insignificant cytotoxicity at static and
dynamic cell culture system. In fact no inflammation and sediments in visceral organs
could be seen at the in vivo animal experiment. Therefore iron base degradable
biomaterials may be an interesting alternative beside established biomaterials.
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