Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Biomaterials
Abstract number: 26114
BIOMIMETIC ION SUBSTITUTED HYDROXYAPATITE COATINGS ON TITANIUM
FOR ORTHOPAEDIC IMPLANTS
Wei XIA 1 , Ahmed BALLO 2 , Carl LINDAHL 1 , Peter THOMSEN 2 , Jukka LAUSMAA 3 ,
Håkan ENGQVIST 1
1 Applied Materials Science, Department of Engineering Sciences, Angstrom
Laboratory, Uppsala University, Uppsala (SWEDEN), 2 Institute for Clinical Sciences,
Sahlgrenska Academy, University of Gothenburg, Gothenburg (SWEDEN),
3 Department of Chemistry and Materials Technology, SP Technical Research
Institute of Sweden, Boras (SWEDEN)
The bonding between implants and bone tissue and inducing new bone formation are
two important things for Orthopaedic implants. Hydroxyapatite (HA) coatings have
been proved to improve the bone bonding strength and new bone formation of
titanium implants. However, the long-time bone bonding and the rate of new bone
formation of HA coatings still need to be further improved. Strontium can reduce the
bone resorption and increase the mechanical strength. Silicon can increase the bone
mineralization and enhance the osteoblast proliferation and collagen production.
Hence, if the strontium and silicon ions are substituted into hydroxyapatite coatings,
the new coatings may improve the long-time bone bonding and enhance the implant
osseointegration. The preparation of ion substituted HA coatings is based on a
biomineralization method. Ti implants are used as substrates. The role of different ion
concentrations and treating temperatures on the coating properties has been
investigated. Early bone response was studied for selected coatings in a rat model.
The results show that homogeneous strontium and silicon HA coatings have been
fabricated with controlled surface morphology, coating thickness and ion
composition. Histological study shows that the new bone is deposited directly onto
the Si and Sr apatite coating without any intervening soft tissue after 7 days.
Quantitative histomorphometrical measurements show more bone in-growth and
bone implant contact (BIC) for Si and Sr coated implant, as compared with HA
coated Ti implants. Based on the above results, these new biomimetic Sr and Si
substituted HA coatings could be good candidates for Orthopaedic implants.
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