Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Biomaterials
Abstract number: 24579
LOCAL HEMOSTATIC EFFECTS OF PARTIALLY ACETYLATED GLUCONIC
CHITINOUS SPONGE
Tomoya MUTA, Kazuo KANEKO, Mutsuhiro MAEDA, Hideaki IWASE
Depertment of Orthopeadic Surgery, School of Medicine, Juntendo University,
Izunokuni (JAPAN)
Chitin and its derivertives have good biocompatibility and potential hemostatic
properties. Hydrochloride and citorate of chitin and chitosan have been developed
and utilized for local hemostatic materials. However, they are insufficient and
restricted forclinical application. The high blood absorption and excellent handling for
porous sponge should required. Novel technology to control homogeneity of porous
materials led to manufacture the gluconic chitonous sponge suitable for the oozing in
orthopaedic surgery. We evaluated the hemostatic potency, blood absorption and
capability in an animal study. Moreover, we conducted an experiment in which
absorbent cotton, collagen hydrochloride, and gluconic chitinous sponge contacted
to human platelet richplasma and Platelet factor 4 (PF-4) and Beta-thrombogloburin
(B-TG) released were measured.As the results, almost 80% of gluconic chitinous
sponge showed hemostatic completion within 5 minutes in oozing from rabbits iliac
bone damage model. Significantly high blood absorption of the sponge excellent
handling in surgery. and also significant hemostatic potency were confirmed in
animal oozing model.. PF-4, B-TG were increased significantly ,which suggested one
of action mechanism of the platelet aggregation by chitinous sponge. We concluded
that gluconic chitonous sponge is a promising local hemostatic material.
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