Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_

Poster
Topic: Biomaterials
Abstract number: 24162
CERAMIC COATINGS ON METALS FOR ANTIBIOTIC DELIVERY
Ana TORRES 1 , F.J. GIL MUR 2 , M FERNANDEZ-FAIREN 2 , A MURCIA ASENSIO 3 ,
Antonio MURCIA MAZON 1
1 Hospital De Cabueñes, Gijon (SPAIN), 2 Instituto de Cirugía Ortopédica y
Traumatología, Barcelona (SPAIN), 3 Hospital Nuestra Señora Del Rossell,
Cartagena (SPAIN),
INTRODUCTION: This project aims to create an antibiotic local delivering coat
employing the calcium phosphate situated on the implant bioactive coating.
MATERIAL The antibiotic is integrated to the calcium phosphate by biomimetics or
thermochemistry methods.The studied antibiotics were tobramicyn, vancomycin and
cefotian. METHODS: Cultures of Staphylococcus aureus have been employed to
check the inhibition of their growth and the percent cumulative drug release from the
calcium phosphate biomimetic coat after time. The implant coating has been study
with a Scanning Electron Microscope and analysed with x-ray diffraction techniques.
RESULTS: The results showed that the addition of the antibiotic doesn’t affect the
crystalline structure and the chemical composition of the implants coatings. The
hydroxyapatite grows with the same pattern in the entire surface; the roughness is
maintained during all the covering process. DISCUSSION: The biomimetic method
allows a uniform distribution of the antibiotic on the calcium phosphate layer
providing a controlled drug release which will prevent or treat locally postoperative
infections. CONCLUSIONS: The host bone doesn’t recognise this homogeneous
coating of antibiotic and calcium phosphate as a foreign and no inflammatory
reactions to foreign bodies appear, reaching important surfaces of direct contact with
the bone in a short period of time. The bone remodelling process starts sooner,
allowing a shorter recovery period, with social and economic advantages associated.
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