Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_
Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_ Abstracts Posters SICOT-SOF meeting Gothenburg 2010 _2_
Poster Topic: Biomaterials Abstract number: 23503 CHONDROPROTECTIVE EFFECTS OF A POLYCARBONATE-URETHANE MENISCAL IMPLANT: SITE-DEPENDENT MANKIN SCORE IN A SHEEP MODEL Jonathan ELSNER 1 , Eran LINDER-GANZ 1 , Gal ZUR 1 , Jonathan SHANI 1 , Ori BRENNER 1 , Elliott HERSHMAN 2 , Avi SHTERLING 1 , Farshid GUILAK 3 1 Active Implants Corporation, Netanya (ISRAEL), 2 Lenox Hill Hospital, New York (UNITED STATES), 3 Duke University Medical Center, Durham (UNITED STATES) Loss or injury of the meniscus generally leads to degenerative osteoarthritic changes in the knee joint. Nevertheless, there are few surgical options currently available for meniscal replacement. The goal of this study was to examine the ability of a nondegradable, anatomically-shaped, polycarbonate-urethane (PCU) meniscal implant, to prevent cartilage degeneration following complete meniscectomy.The artificial PCU-meniscus was implanted in six sheep knees following total medial meniscectomy. The animals were sacrificed at 3 and 6-month post-surgery. Macroscopic analysis and semi-quantitative histological analysis, based on a modified Mankin scale, were performed, separately, on femoral, tibial, and patellar cartilage of the operated knee and compared to the un-operated contralateral control joint in terms of Wilcoxon test. In addition, the scores of 3 and 6-month groups were compared. From gross inspection, the PCU implant remained well-secured throughout the experiment and showed no signs of wear. Microscopic examinations of the explanted implant did not reveal any changes in their structural/material properties. In the majority of sites, Mankin score in both 3 and 6-month groups, did not significantly differ (p>=0.05) between the control and operated knees, except for the patella region, 3-month post-op (p=0.05). Our findings provide evidence for the ability of an artificial PCU meniscal implant to delay or prevent osteoarthritic changes in knee joint following complete medial meniscectomy. 166
Poster Topic: Biomaterials Abstract number: 23683 TANTALUM IMPLANT FOR ADVANCEMENT OF TIBIAL TUBERCLE. A PROSPECTIVE RANDOMIZED STUDY. Ana TORRES 1 , Mariano FERNANDEZ-FAIREN 2 , Alexander JAKOWLEW 2 , Virginia QUERALES 2 , Antonio MURCIA 1 , Jorge BALLESTER 4 1 Hospital de Cabueñes, Gijon (SPAIN), 2 Instituto de Cirugía Ortopédica y Traumatología De Barcelona, Barcelona (SPAIN), 3 Universidad Autónoma de Barcelona, Barcelona (SPAIN) The aim of this prospective randomized controlled trial is to evaluate the effectiveness and safety of a porous tantalum implant in achieving anteriorization of the tibial tubercle in painful patellofemoral degenerative chondral defects. From January 2000-November 2003, 108 knees-101 patients with degenerative patellofemoral cartilage .51 received autologous corticocancellous bone graft (Group 1) and 57 other knees received a porous tantalum implant (Group 2). An arthroscopy was done previously to assess the degree and location of chondral lesions and the patellar tracking .The same senior surgeon carried out all surgeries. The operation time, blood loss, and duration of hospital stay were recorded. Full weight bearing and unrestricted motion were permitted from the first postoperative day. The average duration of surgery was 53minutes (Group 2) versus 98.5 (Group 1). Blood loss was greater for graft group. Clinical results and fusion rate were similar in both groups. There was no influence on the results of t age, sex, weight, preoperative pain or patellofemoral joint space narrowing. The grade of preoperative patellofemoral chondral lesions had a significant predictive value. DISCUSSION: The reliability of the tibial tuberosity advancement to treat patellofemoral chondral lesions remains a controversial issue. An adequate indication and a proper surgical technique facilitate a good result in their treatment. CONCLUSIONS: The result of this study shows the simplicity and the lack of negative effects of this procedure. The operative technique of the tantalum implant is easier and shorter. The high porosity of this implant enhances bone integration. 167
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Poster<br />
Topic: Biomaterials<br />
Abstract number: 23503<br />
CHONDROPROTECTIVE EFFECTS OF A POLYCARBONATE-URETHANE<br />
MENISCAL IMPLANT: SITE-DEPENDENT MANKIN SCORE IN A SHEEP MODEL<br />
Jonathan ELSNER 1 , Eran LINDER-GANZ 1 , Gal ZUR 1 , Jonathan SHANI 1 , Ori<br />
BRENNER 1 , Elliott HERSHMAN 2 , Avi SHTERLING 1 , Farshid GUILAK 3<br />
1 Active Implants Corporation, Netanya (ISRAEL), 2 Lenox Hill Hospital, New York<br />
(UNITED STATES), 3 Duke University Medical Center, Durham (UNITED STATES)<br />
Loss or injury of the meniscus generally leads to degenerative osteoarthritic changes<br />
in the knee joint. Nevertheless, there are few surgical options currently available for<br />
meniscal replacement. The goal of this study was to examine the ability of a nondegradable,<br />
anatomically-shaped, polycarbonate-urethane (PCU) meniscal implant,<br />
to prevent cartilage degeneration following complete meniscectomy.The artificial<br />
PCU-meniscus was implanted in six sheep knees following total medial<br />
meniscectomy. The animals were sacrificed at 3 and 6-month post-surgery.<br />
Macroscopic analysis and semi-quantitative histological analysis, based on a<br />
modified Mankin scale, were performed, separately, on femoral, tibial, and patellar<br />
cartilage of the operated knee and compared to the un-operated contralateral control<br />
joint in terms of Wilcoxon test. In addition, the scores of 3 and 6-month groups were<br />
compared. From gross inspection, the PCU implant remained well-secured<br />
throughout the experiment and showed no signs of wear. Microscopic examinations<br />
of the explanted implant did not reveal any changes in their structural/material<br />
properties. In the majority of sites, Mankin score in both 3 and 6-month groups, did<br />
not significantly differ (p>=0.05) between the control and operated knees, except for<br />
the patella region, 3-month post-op (p=0.05). Our findings provide evidence for the ability of an<br />
artificial PCU meniscal implant to delay or prevent osteoarthritic changes in knee joint<br />
following complete medial meniscectomy.<br />
166
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