Metabolic Effects of Psychotropic Drugs - Karger

New insights into endocrine and obesity-related
consequences of serious mental illness and their
psychopharmacology
Metabolic Effects
of Psychotropic
Drugs
Editors
Jogin Thakore
Brian E. Leonard
Major depression and bipolar disorder are chronic enduring serious mental
illnesses (SMI) with devastating effects on psychosocial functioning and
may culminate in suicide. Over the past years, it has become apparent that
subjects with these conditions can also develop the metabolic syndrome,
which is a series of obesity-related physical conditions with an endocrine
basis.
This book brings together reviews that help put into context exactly why
subjects with SMI develop obesity, prediabetic status, overt type 2 diabetes
mellitus and related cardiovascular events. The relationship between prolactin
and bone mineral density in subjects under medical treatment and
the underlying dopaminergic mechanisms as well as the immunological
changes occurring as an integral part of SMI and their effects on endocrine
function are discussed and reviewed.
Psychiatrists, diabetologists, cardiologists, family practitioners, public
health physicians as well as basic science researchers will find valuable
guidelines when screening for type 2 diabetes mellitus and cardiovascular
disease in SMI.
Modern Trends in Pharmacopsychiatry, Vol. 26
Metabolic Effects of Psychotropic Drugs
Editors: Thakore, J. (Dublin); Leonard B.E. (Galway)
VIII + 134 p., 6 fig., 11 tab., hard cover, 2009
CHF 96.– / EUR 68.50 / USD 96.00
Prices subject to change
EUR price for Germany, USD price for USA only
ISBN 978–3–8055–9001–3
e-ISBN 978–3–8055–9002–0
CONTENTS
Preface
• Metabolic Syndrome and Schizophrenia:
Is Infl ammation the Cause?
Leonard, B.E.
• Insulin Resistance in Bipolar Women:
Eff ects of Mood-Stabilizing Drugs
Vemuri, M.; Stemmle, P.; Jiang, B.;
Morenkova, A.; Rasgon, N.
• Obesity and Mental Illness
Citrome, L.; Vreeland, B.
• Glucose Abnormalities in Schizophrenia,
Bipolar and Major Depressive Disorders
Bushe, C.
• Screening for Diabetes and
Cardiovascular Risk Factors in People
with Serious Mental Illness
Holt, R.I.G.; Peveler, R.C.
• Stress Axis Dysfunction: A Common
Finding in Schizophrenia and the
Metabolic Syndrome?
Afzal, A.; Thakore, J.
• Metabolic Syndrome in Psychiatric
Inpatients Treated for Depression
Goethe, J.W.; Szarek, B.L.; Caley, C.F.
• Hyperprolactinaemia Associated with
Antipsychotic Medications
Fitzgerald, P.; Dinan, T.G.
• Impact of Hyperprolactinaemia on the
General Health of Patients with
Schizophrenia
Wildgust, H.J.; Kohen, D.
Author Index
Subject Index
Fields of Interest
Psychiatry; Pharmacology; Cardiovascular
Systems, Endocrinology,
Immunology Metabolic Diseases,
Neuroendocrinology, Obesity

KP 09103 (2.5.12.09) Printed in Switzerland (1.29; 1.27, 1.14, 1.36, 1.39, 1.01, 1.21)
The book series
Modern Trends in
Pharmacopsychiatry
(formerly ‘Modern Problems of Pharmacopsychiatry’)
Focussing on the effects of drug treatment on psychiatric and neurological disorders,
this series is concerned with the mechanisms of action of psychotropic
drugs, their adverse effects as well as the science and experience behind the
development of new compounds. On the basis of our growing understanding
of the interaction between physical ill health and psychiatric illness, Modern
Trends in Pharmacopsychiatry y also investigates the biological and psychological
factors that may impact on a patient’s response to psychotropic treatment.
Written by international experts who have contributed to the advances in the
field of pharmacopsychiatry, this series provides cutting-edge research and
clinical information, including the latest developments, methods and limitations
of current clinical trials.
Series Editor: Leonard B.E. (Galway)
ISSN 1662–2685
e-ISSN 1662–4505
In preparation
Psychopathology and
Pharmacotherapy of Depression
Editors: John F. Cryan (Cork), Brian E. Leonard (Galway)
Tentative Contents
What’s Wrong With the Current Treatment
of Depression?: Tang, S.W.
The Importance of the HPA Axis in
Depression: Dinan, T.G.
Dysfunctional Circadian Rhythms as a
Target for Novel Antidepressants?:
Trevor, N.
Is Chronic Inflammation a Possible Cause
of Depression?: Leonard, B.L.
The Role of Polyunsaturated Fatty Acids in
the Pathology and Treatment of
Depression: Song, C.
The Nature and Treatment of Therapy
Resistant Depression: Kennedy, S.
Overcoming Antidepressant Treatment
Resistance: Focus on Glutamate:
Matthew, S.; Murrough, J.
Vol. 1–25 available, for more information
please visit
www.karger.com/motph
Importance of Imaging Methods in Understanding
the Psychopathology of
Depression: Cannon, D.
Animal Models of Antidepressant Activity:
Recent Developments: Cryan, J.F:
5-HT and Antidepressant Action: Recent
Advances: Mongeau, R.; Hamon, M.;
Lanfumey, L.
The Noradrenergic System and
Antidepressant Action Recent Advances:
O’Donnell, J.
Molecular Basis of Antidepressant Action:
Recent Advances: Berton, O.
Neurotrophins and Antidepressant Action:
Recent Advances: O’Leary, O.; Castren, E.
Neurogenic Basis of Antidepressant
Action: Recent Advances: Belzung, C.
Pharmacogenomic Differences in the
Behavioural Effects of Antidepressants:
Lucki, I.
The Future of Antidepressants: Stahl, S.
For more information please visit
www.karger.com/motph
Modern Trends in
Pharmacopsychiatry
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copy/ies: Vol. 26: Metabolic Effects of
Psychotropic Drugs
CHF 96.– / EUR 68.50 / USD 96.00
ISBN 978–3–8055–9001–3
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