note - FIZ Karlsruhe
note - FIZ Karlsruhe
note - FIZ Karlsruhe
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L8 ANSWER 3 OF 15 DGENE COPYRIGHT 2010 THOMSON REUTERS on STN<br />
AN AAD21722 cDNA DGENE Full-text<br />
TI Novel stem cell growth factor like polypeptides and polynucleotides for<br />
identifying modulators useful for treating diseases such as Alzheimer's<br />
disease, cancer, rheumatoid arthritis, osteoporosis -<br />
IN Tang T Y; Labat I; Tillinghast J S; Sinku A; Liu C; Drmanac R T;<br />
Stache-Crain B; Dickson M; Mize N K; Nishikawa M<br />
PA (HYSE-N) HYSEQ INC.<br />
(KIRI) KIRIN BEER KK.<br />
PI WO 2001077169 A2 20011018 232<br />
AI WO 2001-US11208 20010405<br />
PRAI US 2000-543774 20000405<br />
US 2000-215733P 20000628<br />
US 2001-757562 20010109<br />
US 2001-266614P 20010205<br />
PSL Example 1; Page 208<br />
DT Patent<br />
LA English<br />
OS 2001-657166 [75]<br />
DESC Human stem cell growth factor-like protein encoding EST cDNA #7.<br />
AB The patent discloses novel stem cell growth factor-like proteins and<br />
polynucleotides encoding them. Proteins of the invention are also known<br />
as supporting factor for the proliferation of stem cells (SCR-1). Stem<br />
cell growth factor-like proteins are useful for supporting proliferation<br />
or survival of a stem cell or germ cell which is preferably primordial<br />
germ cell, germ line stem cell, embryonic stem cell, haematopoietic stem<br />
cell, haematopoietic progenitor cell, pluripotent cell or totipotent<br />
cell. The haematopoietic progenitor cell cultured using stem cell growth<br />
factor-like proteins can replace as a graft for the bone marrow<br />
transplantation or cord blood transplantation for treating a variety of<br />
diseases such as immunodeficiency syndrome, chronic granulomatous<br />
disease, duplicated immunodeficiency syndrome, agammaglobulinaemia,<br />
Wiskott-Aldrich syndrome, acquired immune deficiency syndrome (AIDS),<br />
thalassaemia, . . . . and autoimmune pulmonary inflammation. Sequences of<br />
the invention are also useful in gene therapy. The present sequence is an<br />
EST (expressed sequence tag) cDNA encoding human stem cell growth factor-<br />
like protein.<br />
KW Human; stem cell growth factor-like protein; antiinflammatory; nootropic;<br />
neuroprotective; vulnerary; cytostatic; anticonvulsant; immunostimulant;<br />
vasotropic; virucide; dermatological; tranquilliser; cerebroprotective;<br />
osteopathic; immunodeficiency syndrome; chronic granulomatous disease;<br />
duplicated immunodeficiency syndrome; Wiskott-Aldrich syndrome; AIDS;<br />
acquired immune deficiency syndrome; . . . . supporting factor for the<br />
proliferation of stem cell; EST; expressed sequence tag; ss.<br />
ORGN Homo sapiens.<br />
SQL 390<br />
SCORE 771 100% of query self score 771<br />
BLASTALIGN<br />
Query = 390 letters<br />
Length = 390<br />
Score = 771 bits (389), Expect = 0.0<br />
Identities = 389/389 (100%)<br />
Strand = Plus / Plus<br />
Query: 1 cgttgctctgggatttctttgctggattccagacttttgctgtcaggtattgct . . .<br />
||||||||||||||||||||||||||||||||||||||||||||||||||||||<br />
Sbjct: 1 cgttgctctgggatttctttgctggattccagacttttgctgtcaggtattgct . . .<br />
GENESEQ on STN (DGENE) Workshop Manual | Page 99
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