note - FIZ Karlsruhe
note - FIZ Karlsruhe
note - FIZ Karlsruhe
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Sort the answer set according to similarity score<br />
=> SOR SCORE D<br />
PROCESSING COMPLETED FOR L2<br />
L2 540 SOR L1 SCORE D<br />
Display answers with alignment<br />
=> D TRIAL SCORE ALIGN 1 10 20<br />
Advanced similarity searching<br />
L2 ANSWER 1 OF 540 DGENE COPYRIGHT 2010 THOMSON REUTERS on STN<br />
AN AYC87280 cDNA DGENE<br />
TI Determining if an individual is predisposed to cancer involves<br />
determining presence or absence of KLOTHO functional variant in<br />
heterozygote form.<br />
DESC Human BRCA1 gene mutant (5382insC).<br />
KW BRCA1 gene; Breast cancer 1 susceptibility protein; breast tumor; cancer;<br />
cytostatic; diagnostic test; dna polymorphism; endocrine-gen.; gene;<br />
gynecological; mutant; ovary tumor; pharmacogenetics; prognosis;<br />
screening; ss; therapeutic; uropathic.<br />
SQL 5712<br />
SCORE 62 100% of query self score 62<br />
BLASTALIGN<br />
Query = 31 letters<br />
Length = 5712<br />
Score = 61.9 bits (31), Expect = 2e-14<br />
Identities = 31/31 (100%)<br />
Strand = Plus / Plus<br />
Query: 1 aaaatgtttttaaagaagccagctcaagcaa 31<br />
|||||||||||||||||||||||||||||||<br />
Sbjct: 3217 aaaatgtttttaaagaagccagctcaagcaa 3247<br />
L2 ANSWER 10 OF 540 DGENE COPYRIGHT 2010 THOMSON REUTERS on STN<br />
AN AXX55293 DNA DGENE<br />
TI Inhibiting cardiomyocyte apoptosis and/or improving cardiac function, in<br />
a subject, comprises delivering breast cancer susceptibility gene 1 to<br />
the subject.<br />
DESC Human breast cancer susceptibility gene 1 (BRCA1) isoform DNA, SEQ ID 6.<br />
KW BRCA1 gene; Breast cancer 1 susceptibility protein; antiarteriosclerotic;<br />
antidiabetic; antilipemic; antimicrobial-gen.; apoptosis inhibition;<br />
artery disease; atherosclerosis; cardiac failure; cardiant;<br />
cardiovascular disease; cardiovascular-gen.; cerebroprotective;<br />
cerebrovascular disease; coronary artery disease; diabetes mellitus; drug<br />
delivery; drug screening; ds; endocrine-gen.; familial<br />
hypercholesterolemia; gastrointestinal-gen.; gene therapy; heart disease;<br />
hypertension; hypotensive; inflammation; insulin resistance; intermittent<br />
claudication; ischemia; lipid metabolism disorder; liver disease;<br />
metabolic-gen.; myocardial disease; myocardial infarction; obesity;<br />
prophylactic to disease; protein therapy; pulmonary hypertension;<br />
reperfusion injury; respiratory distress syndrome; respiratory-gen.;<br />
restenosis; sepsis; therapeutic; tumor suppressor; vasotropic.<br />
SQL 6474<br />
(continued on next page)<br />
GENESEQ on STN (DGENE) Workshop Manual | Page 53