note - FIZ Karlsruhe

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L2 540 SOR L1 SCORE D
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L2 ANSWER 1 OF 540 DGENE COPYRIGHT 2010 THOMSON REUTERS on STN
AN AYC87280 cDNA DGENE
TI Determining if an individual is predisposed to cancer involves
determining presence or absence of KLOTHO functional variant in
heterozygote form.
DESC Human BRCA1 gene mutant (5382insC).
KW BRCA1 gene; Breast cancer 1 susceptibility protein; breast tumor; cancer;
cytostatic; diagnostic test; dna polymorphism; endocrine-gen.; gene;
gynecological; mutant; ovary tumor; pharmacogenetics; prognosis;
screening; ss; therapeutic; uropathic.
SQL 5712
SCORE 62 100% of query self score 62
BLASTALIGN
Query = 31 letters
Length = 5712
Score = 61.9 bits (31), Expect = 2e-14
Identities = 31/31 (100%)
Strand = Plus / Plus
Query: 1 aaaatgtttttaaagaagccagctcaagcaa 31
|||||||||||||||||||||||||||||||
Sbjct: 3217 aaaatgtttttaaagaagccagctcaagcaa 3247
L2 ANSWER 10 OF 540 DGENE COPYRIGHT 2010 THOMSON REUTERS on STN
AN AXX55293 DNA DGENE
TI Inhibiting cardiomyocyte apoptosis and/or improving cardiac function, in
a subject, comprises delivering breast cancer susceptibility gene 1 to
the subject.
DESC Human breast cancer susceptibility gene 1 (BRCA1) isoform DNA, SEQ ID 6.
KW BRCA1 gene; Breast cancer 1 susceptibility protein; antiarteriosclerotic;
antidiabetic; antilipemic; antimicrobial-gen.; apoptosis inhibition;
artery disease; atherosclerosis; cardiac failure; cardiant;
cardiovascular disease; cardiovascular-gen.; cerebroprotective;
cerebrovascular disease; coronary artery disease; diabetes mellitus; drug
delivery; drug screening; ds; endocrine-gen.; familial
hypercholesterolemia; gastrointestinal-gen.; gene therapy; heart disease;
hypertension; hypotensive; inflammation; insulin resistance; intermittent
claudication; ischemia; lipid metabolism disorder; liver disease;
metabolic-gen.; myocardial disease; myocardial infarction; obesity;
prophylactic to disease; protein therapy; pulmonary hypertension;
reperfusion injury; respiratory distress syndrome; respiratory-gen.;
restenosis; sepsis; therapeutic; tumor suppressor; vasotropic.
SQL 6474
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GENESEQ on STN (DGENE) Workshop Manual | Page 53