Catalytic Synthesis and Characterization of Biodegradable ...
Catalytic Synthesis and Characterization of Biodegradable ...
Catalytic Synthesis and Characterization of Biodegradable ...
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<strong>Synthesis</strong> <strong>of</strong> Lactide‐Grafted Poly(TEMPO‐acrylamide) <strong>and</strong><br />
its Electrochemical Property <strong>and</strong> Biocompatibility<br />
excellent mechanical properties, they are widely used in pharmaceutical <strong>and</strong> other medical<br />
applications, such as sutures, implants for bone fixation, carriers in drug delivery, <strong>and</strong><br />
temporary matrices or scaffolds in tissue engineering. 17-19 The incorporation <strong>of</strong> PLA fragment<br />
into PTAm will improve the biocompatibility <strong>of</strong> PTAm, <strong>and</strong> the resulting biomaterials will<br />
have promising application in tissue engineering.<br />
4.2 <strong>Synthesis</strong> <strong>of</strong> PTAm-g-PLA<br />
The synthetic route <strong>of</strong> PTAP-g-PLA was shown in Scheme 4.1. Firstly, double bond ended<br />
PLA was synthesized by the ring-opening polymerization <strong>of</strong> lactide initiated by HEMA. Then<br />
the macromonomer was copolymerized with 2,2,6,6-tetrametylpiperidine-4-yl acrylamide<br />
prepared by the reaction <strong>of</strong> 4-amino-2,2,6,6-tetrametylpiperidine with acryl chloride<br />
according to our previous method. 20 The resulted copolymer was oxidized by the peroxide to<br />
give PTAm-g-PLA.<br />
Scheme 4.1 Synthetic routes <strong>of</strong> PTAm-g-PLA.<br />
As shown in Figure 4.1A, the peaks around 6.13 <strong>and</strong> 5.58 ppm were assigned to the<br />
characteristic peaks <strong>of</strong> the double bond <strong>of</strong> HEMA, <strong>and</strong> the peak at 5.19 ppm was attributed to