Catalytic Synthesis and Characterization of Biodegradable ...

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Chapter 1 parameters. Moreover, the morphology of the composites will also be changed with different PPy content (Figure 1.5.7). The fibroblasts exhibited improved attaching and growth on the PPy nanoparticle-PLA composites membranes under the simulated of current compared to that cultured without simulation. The composites provided a new way to design electroactive, biocompatible and biodegradable materials with simple blending approach. Figure 1.5.7 SEM images of the surface of PPy nanoparticle-PLA composite membranes with various PPy content: (A) 5%, (B) 7%, (C) 9%, and (D) 17%. 117 Many cells, especially nerve cell, have filaceous parts which will exhibit different topography. And the topography of culture substrate will influence the growth and differentiation of these cells. Some studies have explored the effect of surface topography of electroactive materials on cell culture. For instance, patterning of 1 and 2 μm wide PPyPSS microchannels can be fabricated using electron beam lithography. 131 Then the embryonic hippocampal neurons were seeded on this matrix and found to polarize (i.e., define an axon) faster, exhibiting a two-fold increase in the number of cells with axons compared to cells cultured on unmodified PPyPSS (Figure 1.5.8). For instance, patterning of 1 and 2 μm wide PPyPSS microchannels can be fabricated using electron beam lithography. 131 Then the embryonic hippocampal neurons were seeded on this matrix and found to polarize (i.e., define an axon) faster, exhibiting a two-fold increase in the number of cells with axons compared to cells cultured on unmodified PPyPSS (Figure 1.5.8). ‐ 26 ‐
- 27 - Polymerization and Applications of Biodegradable Polyesters Figure 1.5.8 Patterning of PPy to create microchannels for contact guidance of neurons. Phase-contrast (left) and fluorescence (right) photomicrographs of hippocampal neurons on PPy. (A, B) Cells cultured on 2 mm wide and 200nm deep PPy microchannels. (C, D) Cells cultured on unmodified PPy. The green labeling (Alexa 488) corresponds to Tau-1 (axonal marker) immunostaining. Cells polarized (i.e., established a single axon) more readily on microchannels than on unmodified PPy. Scale bar = 20 μm. Images are at the same magnification. 131 PANi was another conductive polymer that had been explored for applications as novel intelligent scaffolds for cardiac and/or neuronal tissue engineering. As compared to PPy, the investigation of PANi as biomaterials developed more slowly. However, it is attracting more and more attentions due to the profound understanding on its electrical properties. For example, Mattioli-Belmonte et al. first demonstrated that PANi was biocompatible in vitro and in long term animal studies in vivo. 132 Later, Wei et al. reported that PANi films functionalized with the bioactive lamimin-derived adhesion peptide YIGSR (Tyr-Ile-Gly Ser-Arg) exhibited significant enhanced PC-12 cell attachment and differentiation. 133
Page 1 and 2: Catalytic Synthesis and Characteriz
Page 3 and 4: Preface Biodegradable polyesters ha
Page 5 and 6: Chapter 3 Polymerization of Lactic
Page 7 and 8: Chapter 1 Polymerization and Applic
Page 9 and 10: - 3 - Polymerization and Applicatio
Page 13 and 14: 1.2.2 Aluminum Catalysts - 7 - Poly
Page 17 and 18: 1.3 Polylactide 1.3.1 Introduction
Page 19 and 20: - 13 - Polymerization and Applicati
Page 21 and 22: 1.3.4 Application of PLA Figure 1.3
Page 27 and 28: 1.5.1.4 Polyaniline (PANi) - 21 - P
Page 31: - 25 - Polymerization and Applicati
Page 47 and 48: 1.6.1 Radical Polymers for Organic
Page 51 and 52: initialization of the device by app
Page 55 and 56: 1.6.2.4 Others - 49 - Polymerizatio
Page 63 and 64: 182. R. B. Weller, J. Invest. Derma
Page 65 and 66: Chapter 2 Synthesis and Electrochem
Page 67 and 68: Synthesis and Electrochemistry of S
Page 79: Synthesis and Electrochemistry of S
Page 84 and 85:
Chapter 3 3.1 Introduction Poly(lac
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Chapter 3 polydispersity index (PDI
Page 88 and 89:
Chapter 3 aluminum based complexes
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Chapter 3 3.5 Conclusions Co(III) c
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Chapter 3 22. Z. H. Tang, X. S. Che
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Chapter 4 4.1 Introduction Stimulus
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Chapter 4 the proton of methenyl gr
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Chapter 4 attributed to the amide g
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Chapter 4 4.4 Thermal Properties Th
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Chapter 4 Figure 4.8 MTT assay for
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Chapter 4 The 1 H NMR and 13 C NMR
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Chapter 4 Cell viability (%) = (Asa
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Chapter 5 Synthesis of Triblock Cop
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5.2 Synthesis of Triblock Copolymer
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Sample Table 1. Feed and result com
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= 25 μm. B: MTT assay for the cyto
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‐ 109 ‐ Synthesis of Triblock C
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‐ 111 ‐ Synthesis of Triblock C
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Chapter 6 6.1 Introduction Since th
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Chapter 6 6.3 Synthesis of MPEG-b-P
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Chapter 6 used to characterize the
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Chapter 6 Figure 6.6 Cyclic voltamm
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Chapter 6 vivo cytotoxicity was als
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Chapter 6 NMR. Characterization of
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Chapter 6 CO2 for 24 h. RSC96 cells
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Chapter 7 Conclusion and Future Pro
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‐ 131 ‐ Conclusion and Future P
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‐ 133 ‐ Conclusion and Future P
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13. Xuan Pang, Xuesi Chen, Xiuli Zh
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Acknowledgments The present thesis
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